scholarly journals Effects of topical applications of phosphonoacetate on colonization of mouse trigeminal ganglia with herpes simplex virus type 1.

1984 ◽  
Vol 26 (1) ◽  
pp. 65-68 ◽  
Author(s):  
R J Klein ◽  
A E Friedman-Kien ◽  
L Kaley ◽  
E Brady
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Simplex Virus ◽  
Topical Applications

Viable herpes simplex virus type 1 and varicella-zoster virus in the trigeminal ganglia of human cadavers

2013 ◽  
Vol 85 (5) ◽  
pp. 833-838 ◽  
Author(s):  
Hisako Saitoh ◽  
Yuko Momma ◽  
Hiroyuki Inoue ◽  
Daisuke Yajima ◽  
Hirotaro Iwase
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Varicella Zoster ◽  
Human Cadavers ◽  
Simplex Virus

scholarly journals Efficacies of Gel Formulations Containing Foscarnet, Alone or Combined with Sodium Lauryl Sulfate, against Establishment and Reactivation of Latent Herpes Simplex Virus Type 1

2001 ◽  
Vol 45 (4) ◽  
pp. 1030-1036 ◽  
Author(s):  
Jocelyne Piret ◽  
Julie Lamontagne ◽  
André Désormeaux ◽  
Michel G. Bergeron
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Sodium Lauryl Sulfate ◽  
Trigeminal Ganglia ◽  
Lauryl Sulfate ◽  
Simplex Virus ◽  
Gel Formulations

ABSTRACT The influence of sodium lauryl sulfate (SLS) on the efficacies of gel formulations of foscarnet against herpes simplex virus type 1 (HSV-1) cutaneous lesions and on the establishment and reactivation of latent virus has been evaluated in a murine model of orofacial infection. Topical treatments were given twice daily for 3 days and were initiated at 6, 24, and 48 h after virus inoculation. The gel formulation that contained both 3% foscarnet and 5% SLS and that was administered within 48 h postinfection reduced the rate of development of herpetic skin lesions. This formulation also significantly decreased the viral content in skin tissues and in ipsilateral trigeminal ganglia when it was given within 24 and 6 h postinfection, respectively. A lower level of efficacy was observed for the gel formulation containing 3% foscarnet alone. Of prime interest, the gel formulation containing 5% SLS reduced significantly the mortality rate among mice in a zosteriform model of infection. Both formulations of foscarnet had no effect on the mean titers of reactivated virus in explant cultures of ipsilateral and contralateral trigeminal ganglia from latently infected mice. The use of a gel formulation containing combinations of foscarnet and SLS could represent an attractive approach for the treatment of herpetic mucocutaneous infections.

scholarly journals Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals

2012 ◽  
Vol 205 (10) ◽  
pp. 1539-1543 ◽  
Author(s):  
Monique van Velzen ◽  
Freek B. van Loenen ◽  
Roland J. W. Meesters ◽  
Miranda de Graaf ◽  
Lies Remeijer ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Simplex Virus

scholarly journals Latent herpes simplex virus type 1 transcription in human trigeminal ganglia.

1988 ◽  
Vol 62 (9) ◽  
pp. 3493-3496 ◽  
Author(s):  
I Steiner ◽  
J G Spivack ◽  
D R O'Boyle ◽  
E Lavi ◽  
N W Fraser
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Simplex Virus
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