scholarly journals Prevalence and Susceptibility Profile of Candida metapsilosis and Candida orthopsilosis: Results from Population-Based Surveillance of Candidemia in Spain

2008 ◽  
Vol 52 (4) ◽  
pp. 1506-1509 ◽  
Author(s):  
A. Gomez-Lopez ◽  
A. Alastruey-Izquierdo ◽  
D. Rodriguez ◽  
B. Almirante ◽  
A. Pahissa ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Population Based ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis ◽  
Susceptibility Profiles

ABSTRACT We describe the prevalences and susceptibility profiles of two recently described species, Candida metapsilosis and Candida orthopsilosis, related to Candida parapsilosis in candidemia. The prevalences of these species (1.7% for C. metapsilosis and 1.4% for C. orthopsilosis) are significant. Differences observed in their susceptibility profiles could have therapeutic importance.

scholarly journals Prevalence, distribution and antifungal susceptibility profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis bloodstream isolates

2012 ◽  
Vol 61 (7) ◽  
pp. 1003-1008 ◽  
Author(s):  
Lucas Xavier Bonfietti ◽  
Marilena dos Anjos Martins ◽  
Maria Walderez Szeszs ◽  
Sandra Brasil Stolf Pukiskas ◽  
Sonia Ueda Purisco ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Antifungal Susceptibility ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis ◽  
Susceptibility Profiles

scholarly journals A case series of medically managed Candida parapsilosis complex prosthetic valve endocarditis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Penghao Guo ◽  
Yuting He ◽  
Rui Fan ◽  
Zhongwen Wu ◽  
Yili Chen ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Candida Parapsilosis ◽  
Case Series ◽  
Prosthetic Valve Endocarditis ◽  
Sensu Stricto ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis ◽  
Tof Ms

Abstract Background In recent years, Candida parapsilosis is recognized as a species complex and is composed of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. Candida parapsilosis complex prosthetic valve endocarditis (PVE) is rare and the survival rate is still low despite of optimal therapeutic strategies. In our report, it is novel to report cases as Candida parapsilosis complex PVE at species and identify Candida parapsilosis using MALDI-TOF MS. Case presentation A series of 4 cases of Candida parapsilosis complex PVE from our institution was reported. Three were infected by Candida parapsilosis sensu stricto and one was infected by Candida metapsilosis. The condition of two cases got better and the other died. Conclusions More attention should be paid to Candida parapsilosis complex PVE and early diagnosis and prompt antibiotic therapy may play a role in the treatment for Candida parapsilosis complex PVE. It is recommended to identify Candida parapsilosis complex at species level and MALDI-TOF MS as an easy, fast and efficient identification method is worth promoting in clinical microbiology

Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models

2007 ◽  
Vol 44 (12) ◽  
pp. 1336-1341 ◽  
Author(s):  
Attila Gácser ◽  
Wilhelm Schäfer ◽  
Jerome S. Nosanchuk ◽  
Siegfried Salomon ◽  
Joshua D. Nosanchuk
Keyword(s):  
Human Tissue ◽  
Candida Parapsilosis ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis ◽  
Tissue Models

scholarly journals A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility

2008 ◽  
Vol 52 (7) ◽  
pp. 2305-2312 ◽  
Author(s):  
Guillermo Garcia-Effron ◽  
Santosh K. Katiyar ◽  
Steven Park ◽  
Thomas D. Edlind ◽  
David S. Perlin
Keyword(s):  
Amino Acid ◽  
Candida Parapsilosis ◽  
Hot Spot ◽  
Amino Acid Position ◽  
Intrinsic Resistance ◽  
Glucan Synthase ◽  
Equivalent Position ◽  
Naturally Occurring ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis

ABSTRACT Candida parapsilosis has emerged as a common cause of invasive fungal infection, especially in Latin America and in the neonatal setting. C. parapsilosis is part of a closely related group of organisms that includes the species Candida orthopsilosis and Candida metapsilosis. All three species show elevated MICs for the new echinocandin class drugs caspofungin, micafungin, and anidulafungin relative to other Candida species. Despite potential impacts on therapy, the mechanism behind this reduced echinocandin susceptibility has not been determined. In this report, we investigated the role of a naturally occurring Pro-to-Ala substitution at amino acid position 660 (P660A), immediately distal to the highly conserved hot spot 1 region of Fks1p, in the reduced-echinocandin-susceptibility phenotype. Kinetic inhibition studies demonstrated that glucan synthase from the C. parapsilosis group was 1 to 2 logs less sensitive to echinocandin drugs than the reference enzyme from C. albicans. Furthermore, clinical isolates of C. albicans and C. glabrata which harbor mutations at this equivalent position also showed comparable 2-log decreases in target enzyme sensitivity, which correlated with increased MICs. These mutations also resulted in 2.4- to 18.8-fold-reduced V max values relative to those for the wild-type enzyme, consistent with kinetic parameters obtained for C. parapsilosis group enzymes. Finally, the importance of the P660A substitution for intrinsic resistance was confirmed by engineering an equivalent P647A mutation into Fks1p of Saccharomyces cerevisiae. The mutant glucan synthase displayed characteristic 2-log decreases in sensitivity to the echinocandin drugs. Overall, these data firmly indicate that a naturally occurring P660A substitution in Fks1p from the C. parapsilosis group accounts for the reduced susceptibility phenotype.

scholarly journals Molecular differentiation and antifungal susceptibilities of Candida parapsilosis isolated from patients with bloodstream infections

2009 ◽  
Vol 58 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Sun Tee Tay ◽  
Shiang Ling Na ◽  
Jennifer Chong
Keyword(s):  
Candida Parapsilosis ◽  
Susceptibility Testing ◽  
Rapd Analysis ◽  
Antifungal Susceptibility ◽  
Bloodstream Infections ◽  
Candida Metapsilosis ◽  
Significant Difference ◽  
Its Gene ◽  
Candida Orthopsilosis ◽  
Susceptibility Patterns

The genetic heterogeneity and antifungal susceptibility patterns of Candida parapsilosis isolated from blood cultures of patients were investigated in this study. Randomly amplified polymorphic DNA (RAPD) analysis generated 5 unique profiles from 42 isolates. Based on the major DNA fragments of the RAPD profiles, the isolates were identified as RAPD type P1 (29 isolates), P2 (6 isolates), P3 (4 isolates), P4 (2 isolates) and P5 (1 isolate). Sequence analysis of the internal transcribed spacer (ITS) gene of the isolates identified RAPD type P1 as C. parapsilosis, P2 and P3 as Candida orthopsilosis, P4 as Candida metapsilosis, and P5 as Lodderomyces elongisporus. Nucleotide variations in ITS gene sequences of C. orthopsilosis and C. metapsilosis were detected. Antifungal susceptibility testing using Etests showed that all isolates tested in this study were susceptible to amphotericin B, fluconazole, ketoconazole, itraconazole and voriconazole. C. parapsilosis isolates exhibited higher MIC50 values than those of C. orthopsilosis for all of the drugs tested in this study; however, no significant difference in the MICs for these two Candida species was observed. The fact that C. orthopsilosis and C. metapsilosis were responsible for 23.8 and 4.8 % of the cases attributed to C. parapsilosis bloodstream infections, respectively, indicates the clinical relevance of these newly described yeasts. Further investigations of the ecological niche, mode of transmission and virulence of these species are thus essential.

Comparison of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis adhesive properties and pathogenicity

2013 ◽  
Vol 303 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Alessia Bertini ◽  
Flavia De Bernardis ◽  
Lambert A.M. Hensgens ◽  
Silvia Sandini ◽  
Sonia Senesi ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Adhesive Properties ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis

scholarly journals Candida orthopsilosis and Candida metapsilosis spp. nov. To Replace Candida parapsilosis Groups II and III

2005 ◽  
Vol 43 (1) ◽  
pp. 284-292 ◽  
Author(s):  
A. Tavanti ◽  
A. D. Davidson ◽  
N. A. R. Gow ◽  
M. C. J. Maiden ◽  
F. C. Odds
Keyword(s):  
Candida Parapsilosis ◽  
Candida Metapsilosis ◽  
Candida Orthopsilosis
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