scholarly journals In Vitro Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus, Including Heterogeneously Glycopeptide-Resistant Strains

2006 ◽  
Vol 50 (9) ◽  
pp. 3189-3191 ◽  
Author(s):  
Bram M. W. Diederen ◽  
Inge van Duijn ◽  
Piet Willemse ◽  
Jan A. J. W. Kluytmans
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Susceptibility Testing ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant ◽  
Resistant Strains

ABSTRACT The purpose of the present study was to assess the in vitro activity of daptomycin against a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 98), including heterogeneously glycopeptide-resistant MRSA (hGISA) strains. Susceptibility testing was performed by using the Etest system. Daptomycin was potent against both glycopeptide-susceptible and hGISA strains.

scholarly journals In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus

2011 ◽  
Vol 64 (8) ◽  
pp. 559-562 ◽  
Author(s):  
Chunguang Sun ◽  
Matthew E Falagas ◽  
Rui Wang ◽  
Drosos E Karageorgopoulos ◽  
Xuhong Yu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Methicillin Resistant

scholarly journals In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus

2009 ◽  
Vol 53 (10) ◽  
pp. 4495-4497 ◽  
Author(s):  
Shveta Rani Singh ◽  
Alfred E. Bacon ◽  
David C. Young ◽  
Kimberly A. Couch
Keyword(s):  
Staphylococcus Aureus ◽  
Conventional Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antagonistic Activity ◽  
Vitro Activity ◽  
Synergistic Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant ◽  
Time Kill

ABSTRACT Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

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