scholarly journals Activity of Faropenem against Middle Ear Fluid Pathogens from Children with Acute Otitis Media in Costa Rica and Israel

2007 ◽  
Vol 51 (6) ◽  
pp. 2230-2235 ◽  
Author(s):  
Kimberley Clawson Stone ◽  
Ron Dagan ◽  
Adriano Arguedas ◽  
Eugene Leibovitz ◽  
Elaine Wang ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Costa Rica ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Streptococcus Pyogenes ◽  
Middle Ear ◽  
Moraxella Catarrhalis ◽  
Acute Otitis Media ◽  
The Other ◽  
Middle Ear Fluid

ABSTRACT Faropenem was tested against 1,188 middle ear fluid pathogens from children in Israel and Costa Rica. Against Streptococcus pneumoniae and Haemophilus influenzae, faropenem was the most active β-lactam, with activity that was similar to or greater than of the other oral antimicrobial classes studied. Faropenem was also active against Moraxella catarrhalis and Streptococcus pyogenes.

Failure of antibiotic therapy in acute otitis media

2003 ◽  
Vol 117 (3) ◽  
pp. 173-176 ◽  
Author(s):  
Emmanuel Babin ◽  
Vincent Lemarchand ◽  
Sylvain Moreau ◽  
Marc Goullet de Rugy ◽  
André Valdazo ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Antibiotic Therapy ◽  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Bacterial Strains ◽  
Middle Ear Fluid ◽  
Two Samples ◽  
Microbiological Techniques

The aim of this retrospective study was to determine the possible causes of failure of antibiotic therapy in children with acute otitis media (AOM). Thirty-nine samples of middle-ear fluid were obtained by myringotomy from 31 children suffering from AOM, unrelieved by antibiotic therapy administered for over 48 hours. The samples were analysed by the usual microbiological techniques, including cultures, tests for beta-lactamase producing strains and the determination of the minimal inhibitory concentration of penicillin for Streptococcus pneumoniae. In 14 samples, no bacterial strains were detected in the cultures of middle-ear fluid; and in two samples the cultures revealed two strains of bacteria. The bacteria most frequently identified were Haemophilus influenzae, found in 11 samples, and Streptococcus pneumoniae, found in seven samples, of which four produced strains with reduced susceptibility to penicillin. The failure of antibiotic therapy in AOM appears to be related to the increased resistance of Haemophilus influenzae and to the reduced susceptibility of Streptococcus pneumoniae to penicillin. Other factors contributing to the failure of antibiotic therapy in AOM may be the viruses or the bacteria that produce multiple pathogens in the middle ear.

Immune Response to Acute Otitis Media: Association Between Middle Ear Fluid Antibody and the Clearing of Clinical Infection

1976 ◽  
Vol 4 (3) ◽  
pp. 306-308
Author(s):  
John L. Sloyer ◽  
Virgil M. Howie ◽  
John H. Ploussard ◽  
Gerald Schiffman ◽  
Richard B. Johnston
Keyword(s):  
Immune Response ◽  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Middle Ear ◽  
Specific Antibody ◽  
Acute Otitis Media ◽  
Clinical Infection ◽  
Middle Ear Fluid

Clearing of the middle ear fluid in patients with acute otitis media due to Streptococcus pneumoniae or Haemophilus influenzae was significantly associated with the presence and concentration of specific antibody in the middle ear fluid at the time of diagnosis.

scholarly journals Otitis media: conceptos actuales

2009 ◽  
Vol 46 (3) ◽  
Author(s):  
Hernán Sierra Fernández ◽  
Malka Schutz Faingezicht ◽  
Cecilia Loaiza Mendoza ◽  
Adriano Arguedas Mohs
Keyword(s):  
Streptococcus Pneumoniae ◽  
Costa Rica ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Streptococcus Pyogenes ◽  
Moraxella Catarrhalis

La otitis media aguda es uno de los motivos más frecuentes de consulta en la edad pediátrica. Los gérmenes que con mayor frecuencia se aíslan en el oído medio de estos pacientes son el Streptococcus pneumoniae, el Haemophilus influenzae, la Moraxella catarrhalis y el Streptococcus pyogenes. El patrón de resistencia antibiótica de estas bacterias varía dependiendo de la región geográfica, y es la base fundamental para establecer recomendaciones terapéuticas. El análisis en Costa Rica, de la microbiología de la otitis media aguda, otitis media recurrente y otitis media catalogada como falla terapéutica, sugiere que la amoxicilina en una dosis de 50 mg/Kg/día por 10 días, debe ser considerada el antibiótico de primera línea en los casos de otitis media aguda. En los pacientes con otitis media recurrente, falla antimicrobiana o cuando se sospeche la presencia de un Streptococcus pneumoniae resistente a la penicilina, se debe considerar el uso de amoxicilina en dosis más elevadas, amoxicilina con ácido clavulánico, macrólidos o ceftriaxona.

MIDDLE-EAR FLUID STREPTOCOCCUS PNEUMONIAE SUSCEPTIBILITY AND SEROTYPE AND DISTRIBUTION IN MEXICAN CHILDREN WITH ACUTE OTITIS MEDIA

PEDIATRICS ◽  
2008 ◽  
Vol 121 (Supplement 2) ◽  
pp. S129.2-S129 ◽  
Author(s):  
Claudia Lopez-Enriquez ◽  
A. Blanco-Montero ◽  
L. E. Espinosa-Monteros ◽  
R. Rodriguez ◽  
C. De La Torre ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Mexican Children ◽  
Middle Ear Fluid

scholarly journals Streptococcus pneumoniae Isolates from Middle Ear Fluid and Nasopharynx of Children with Acute Otitis Media Exhibit Phase Variation

2011 ◽  
Vol 49 (4) ◽  
pp. 1646-1649 ◽  
Author(s):  
J. Arai ◽  
M. Hotomi ◽  
S. K. Hollingshead ◽  
Y. Ueno ◽  
D. E. Briles ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Phase Variation ◽  
Middle Ear Fluid

Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection

2013 ◽  
Vol 142 (10) ◽  
pp. 2186-2194 ◽  
Author(s):  
V. FRIEDEL ◽  
S. ZILORA ◽  
D. BOGAARD ◽  
J. R. CASEY ◽  
M. E. PICHICHERO
Keyword(s):  
Risk Factors ◽  
Streptococcus Pneumoniae ◽  
Prospective Study ◽  
Otitis Media ◽  
Moraxella Catarrhalis ◽  
Acute Otitis Media ◽  
Middle Ear Fluid ◽  
Modelling Analysis ◽  
History Of ◽  
Pneumococcal Colonization

SUMMARYDuring a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006–June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged <5 years increased the risk of Streptococcus pneumoniae NP colonization. NP colonization with S. pneumoniae, M. catarrhalis, or Haemophilus influenzae and a family history of OM increased the risk of AOM. Risk factors that increase the risk of pneumococcal AOM will be important to reassess as we move into a new 13-valent PCV era, especially co-colonization with other potential otopathogens.

Sign in / Sign up

Export Citation Format

Share Document