Condylus tertius: A review of a neglected developmental condition

2021 ◽  
Author(s):  
Ana González-Ruiz ◽  
Ana Luisa Santos
Keyword(s):  
Developmental Condition

INFLUENCE OF DEVELOPMENTAL CONDITION OF SAND SPIT ON INTRUSION CHARACTERISTICS OF WAVES INTO AN ESTUARY

2019 ◽  
Vol 75 (2) ◽  
pp. I_253-I_258
Author(s):  
Yuki KAJIKAWA ◽  
Natsumi WADA ◽  
Masamitsu KUROIWA ◽  
Takashi KATAYAMA
Keyword(s):  
Sand Spit ◽  
Developmental Condition

An evaluation of the online post-diagnostic groups facilitated by the autism spectrum condition service at Gloucestershire Health and Care NHS

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Victoria Anne Hatton ◽  
Ming Xuan Lee
Keyword(s):  
Sense Of Belonging ◽  
Service Evaluation ◽  
Autism Spectrum ◽  
Support Network ◽  
Autism Spectrum Condition ◽  
Content Type ◽  
Face To Face ◽  
Spectrum Condition ◽  
Developmental Condition ◽  
Online Group

Purpose Autism spectrum condition (ASC) is a lifelong developmental condition. According to research, it is recommended that those diagnosed with ASC should be offered post-diagnosis support to explore their diagnosis (Punshow, Skirrow and Murphy, 2009). The ASC Diagnostic Assessment Service at Gloucestershire Health Care (GHC) NHS Foundation Trust offers an assessment service to adults (18+) located within Gloucestershire. All those who receive a diagnosis are then invited to a 7-week post-diagnostic group facilitated by the multidisciplinary team. This service evaluation aimed to evaluate the aforementioned group so that it can be improved upon and thus provide a better service for future clients. Design/methodology/approach In total, 14 participants (6 males, 8 females) were interviewed for the purpose of this evaluation following their attendance at these groups. Findings The interview transcripts then underwent thematic analysis with four themes identified; “Autistic Community”, “Experience of Being Part of an Online Group”, “Opportunity for Consolidation”, and “Design Considerations and Improvements”. Further sub-themes were also identified. Overall, the service evaluation identified that the group provided a platform for sharing experiences and gaining a sense of belonging. It also highlighted that individuals have different preferences for whether groups should be facilitated online or face-to-face, and also different preferences for the duration of sessions. Further analysis also revealed the suggestion that the final session, for family and friends, should be optional so that those without a support network, do not need to attend as this caused unease in some. Further findings were also identified. Originality/value To the authors’ knowledge, existing articles have only focused on the evaluation of the availability of post-diagnostic provision and autistic individuals’ general impression of it rather than an in-depth evaluation of a specific type of support.

Autism Spectrum Disorder, Fear Response, and Environmental Exposures

2019 ◽  
pp. 30-51 ◽  
Author(s):  
Theoharis C. Theoharides ◽  
Jaanvi Sant ◽  
Maria-Eleni Giota
Keyword(s):  
Autism Spectrum Disorder ◽  
Mast Cells ◽  
Effective Treatment ◽  
Immune Cells ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fear Response ◽  
Environmental Stimuli ◽  
Flight Reaction ◽  
Developmental Condition

Autism spectrum disorder (ASD) is a developmental condition characterized by impaired social interactions and communication, as well as by stereotypic movements, that affects 1 in 59 children. ASD is expected to reach 1 in about 40 children by 2020, yet it remains without distinct pathogenesis and effective treatment. Children with ASD respond with high anxiety to almost any unknown stimulus and appear to misread danger/threat signals, and may not experience anxiety in situations where normotypic children do. The authors propose that environmental stimuli stimulate the unique immune cells, known as mast cells (MC), which then trigger microglia, leading to dysfunctional neuronal connectivity in the amygdala. This process lowers or disrupts the “fear response” and leads to an exaggerated “fight-or-flight” reaction. corticotropin-releasing hormone (CRH) could have a synergistic effect with environmental stimuli, especially mycotoxins. Recognizing this association and preventing stimulation of mast cells/microglia could lead to effective treatment of ASD.

scholarly journals From congenial paralysis to post-early brain injury developmental condition: Where does cerebral palsy actually stand?

2020 ◽  
Vol 63 (5) ◽  
pp. 431-438 ◽  
Author(s):  
Stéphane Chabrier ◽  
Margaux Pouyfaucon ◽  
Alain Chatelin ◽  
Yannick Bleyenheuft ◽  
Joel Fluss ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Early Brain Injury ◽  
Developmental Condition

scholarly journals Case Report: Trance in Mental Retardation

2021 ◽  
Vol 9 (T3) ◽  
pp. 31-34
Author(s):  
Mustafa Mahmud Amin ◽  
Elmeida Effendy ◽  
Ferdinan Leo Sianturi ◽  
Munawir Saragih ◽  
Syaifuddin Nasution
Keyword(s):  
Mental Retardation ◽  
Case Report ◽  
Altered State ◽  
Psychosocial Stressor ◽  
Altered State Of Consciousness ◽  
Psychiatric Conditions ◽  
Dissociative Trance Disorder ◽  
Developmental Condition ◽  
Culture And Communication

BACKGROUND: Mental retardation (MR) is a developmental condition that is associated with significant intellectual and adaptive behavioral limitations, whereas dissociative trance disorder (DTD) is a dissociative condition characterized by a temporary altered state of consciousness formed by one’s culture. Comorbidity between these two disorders has rarely been reported. CASE REPORT: We found a case of MR in a 32-year-old woman, Mrs. S, with a DTD who killed her five children during her trance. CONCLUSION: It was found that there is a relationship between psychosocial stressor factors, trauma, underlying psychiatric conditions, culture, and communication that influence trance conditions. Further research is needed to study and understand more about these disorders and comorbidities.

scholarly journals Hubungan psychological capital dengan komitmen organisasi pada aparatur sipil negara

Cognicia ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 121-129
Author(s):  
Gustina Anggraini
Keyword(s):  
Organizational Commitment ◽  
Hypothesis Testing ◽  
Self Efficacy ◽  
Quantitative Research ◽  
Positive Relationship ◽  
Psychological Capital ◽  
Psychological State ◽  
One Year ◽  
The Relationship ◽  
Developmental Condition

Organizational commitment is the willingness of members to have a relationship with the organization. High organizational commitment will lead to high on aspects like performance, discipline and achievement. A positive psychological state must be possessed because it can affect organizational commitment. Psychological capital is a developmental condition of a person’s positive psychological state and the emergence of self-efficacy, hope, resilience, and optimism so that it is related to organizational commitment. The purpose of the study was to determine the relationship between psychological capital and organizational commitment in ASN samples. Quantitative research in design and the data gathered from 125 ASN participants with at least one year of working experience in an organization or agency. Data were collected using psychological capital (PCQ) and organizational commitment scale (OCQ). Hypothesis testing was carried out with Pearson’s product moment correlation using SPSS. The results showed that there was a positive relationship between psychological capital and organizational commitment in state civil apparatus (r=0.87, p=0.000). It means the higher the psychological capital, the higher the organizational commitment.   Keywords: Organizational commitment, psychological capital, state civil apparatus

scholarly journals Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Katherine A Donovan ◽  
Jian An ◽  
Radosław P Nowak ◽  
Jingting C Yuan ◽  
Emma C Fink ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Birth Defects ◽  
Molecular Basis ◽  
Congenital Heart ◽  
Loss Of Function ◽  
Morning Sickness ◽  
Species Specific ◽  
Developmental Condition

In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment; however, the molecular basis underlying the pleiotropic biology and characteristic birth defects remains unknown. Here we show that IMiDs disrupt a broad transcriptional network through induced degradation of several C2H2 zinc finger transcription factors, including SALL4, a member of the spalt-like family of developmental transcription factors. Strikingly, heterozygous loss of function mutations in SALL4 result in a human developmental condition that phenocopies thalidomide-induced birth defects such as absence of thumbs, phocomelia, defects in ear and eye development, and congenital heart disease. We find that thalidomide induces degradation of SALL4 exclusively in humans, primates, and rabbits, but not in rodents or fish, providing a mechanistic link for the species-specific pathogenesis of thalidomide syndrome.

Stability of Isthmic Spondylolisthesis: Finite Element Model Study

2000 ◽  
Author(s):  
R. N. Natarajan ◽  
R. B. Garretson ◽  
H. An ◽  
G. B. J. Andersson
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Loading Condition ◽  
Element Model ◽  
Isthmic Spondylolisthesis ◽  
Model Study ◽  
Pars Interarticularis ◽  
Loading Modes ◽  
Moment Load ◽  
Developmental Condition

Abstract Spondylolysis is a developmental condition or a stress fracture phenomenon, in which a defect in the pars interarticularis leads to varying degrees of instability in the lumbar spine. A finite element model was used to study the effect of pars defect as well as pars defect combined with varying slip on the change in flexibility of the lumbar motion segments under mechanical loading. Compared to the intact model, a pars defect at L3–L4 level allowed a small increase in motion at L2 with respect to L5 under all loading modes except torsion. Motion of L2 with respect to L5 was further increased by 3% to 20% with 50% translation prior to loading in all loading modes except torsion. Fifty percent translation increased the torsion motion further by 50%. In every model, the increase in motion was greatest under torsion. This study showed that stability of a motion segment in spondylolysis depends on the amount of spondylolisthesis and the loading condition. There was more motion with increased slip in all-loading modes with largest increase with torsion moment load. The type of loading also affects the degree of motion, with torsion creating significant instability.

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