Death Receptor Signaling Giving Life to Ectodermal Organs

2002 ◽  
Vol 2002 (131) ◽  
pp. pe22-pe22 ◽  
Author(s):  
I. Thesleff ◽  
M. L. Mikkola
Keyword(s):  
Death Receptor ◽  
Receptor Signaling ◽  
Death Receptor Signaling

Beyond apoptosis: nonapoptotic cell death in physiology and disease

2005 ◽  
Vol 83 (5) ◽  
pp. 579-588 ◽  
Author(s):  
Claudio A Hetz ◽  
Vicente Torres ◽  
Andrew F.G Quest
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Death Receptor ◽  
Receptor Signaling ◽  
Family Analysis ◽  
Caspase Family ◽  
Death Receptor Signaling ◽  
Apoptotic Pathways ◽  
Nonapoptotic Cell Death ◽  
High Degree

Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathological conditions, cells demonstrate a high degree of flexibility in cell-death responses, as is reflected in the existence of a variety of mechanisms, including necrosis-like PCD, autophagy (or type II PCD), and accidental necrosis. In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways.Key words: apoptosis, necrosis, nonapoptotic programmed cell death, death receptors, ceramides.

scholarly journals Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP

Redox Biology ◽  
2020 ◽  
Vol 30 ◽  
pp. 101403 ◽  
Author(s):  
Jayshree L. Hirpara ◽  
Kothandharaman Subramaniam ◽  
Gregory Bellot ◽  
Jianhua Qu ◽  
Serena Seah ◽  
...  
Keyword(s):  
Death Receptor ◽  
Receptor Signaling ◽  
Inhibitory Protein ◽  
Induced Expression ◽  
Death Receptor Signaling

scholarly journals Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

FEBS Journal ◽  
2009 ◽  
Vol 276 (15) ◽  
pp. 4256-4265 ◽  
Author(s):  
Niko Föger ◽  
Silvia Bulfone-Paus ◽  
Andrew C. Chan ◽  
Kyeong-Hee Lee
Keyword(s):  
Death Receptor ◽  
Receptor Signaling ◽  
Death Receptor Signaling ◽  
Subcellular Compartmentalization

scholarly journals Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired Chemoresistance

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
James W. Antoon ◽  
Rongye Lai ◽  
Amanda P. Struckhoff ◽  
Ashley M. Nitschke ◽  
Steven Elliott ◽  
...  
Keyword(s):  
Epithelial To Mesenchymal Transition ◽  
Death Receptor ◽  
Receptor Signaling ◽  
Mesenchymal Transition ◽  
Death Receptor Signaling

scholarly journals Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

2020 ◽  
Vol 10 (4) ◽  
pp. 552-567 ◽  
Author(s):  
Nathan Singh ◽  
Yong Gu Lee ◽  
Olga Shestova ◽  
Pranali Ravikumar ◽  
Katharina E. Hayer ◽  
...  
Keyword(s):  
T Cell ◽  
Death Receptor ◽  
Receptor Signaling ◽  
Cell Dysfunction ◽  
Car T Cell ◽  
Car T ◽  
T Cell Dysfunction ◽  
Death Receptor Signaling
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