Transforming platelets into microrobots

2020 ◽  
Vol 5 (43) ◽  
pp. eabc6582
Author(s):  
Jinjun Shi
Keyword(s):  
Drug Delivery ◽  
Active Movement ◽  
Improve Drug Delivery

Biocompatible cell robots powered by urea improve drug delivery through active movement.

Design of Lipophilic Prodrugs to Improve Drug Delivery and Efficacy

2016 ◽  
Vol 17 (15) ◽  
pp. 1773-1798 ◽  
Author(s):  
Abhirup Mandal ◽  
Mitesh Patel ◽  
Ye Sheng ◽  
Ashim K. Mitra
Keyword(s):  
Drug Delivery ◽  
Lipophilic Prodrugs ◽  
Improve Drug Delivery

Studies on drug-assisted silver nanoparticles to reduce granulocytopenia and improve drug delivery for cancer therapy

2021 ◽  
Vol 127 (5) ◽  
Author(s):  
Chetan Chavan ◽  
Saniya Prabhune ◽  
Siddhi Shedge ◽  
Rajashree Patwardhan ◽  
Sagar Kamble ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Therapy ◽  
Improve Drug Delivery

scholarly journals CADD-06. VISMODEGIB LOADED POLYOXAZOLINE (POx) MICELLES ENHANCE EFFICACY OF VISMODEGIB AND PROLONG MICE SURVIVAL, EMPHASIZE POTENTIAL OF POx MICELLES TO IMPROVE DRUG DELIVERY TO BRAIN TUMORS

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi278-vi278
Author(s):  
Duhyeong Hwang ◽  
Chaemin Lim ◽  
Yuling Zhao ◽  
Hedi Liu ◽  
Alexander V Kabanov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Improve Drug Delivery

Hyperthermia Improves Solubility of Intravesical Chemotherapeutic Agents

2020 ◽  
Vol 6 (4) ◽  
pp. 461-470
Author(s):  
Dominic C. Grimberg ◽  
Ankeet Shah ◽  
Wei Phin Tan ◽  
Wiguins Etienne ◽  
Ivan Spasojevic ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mitomycin C ◽  
Room Temperature ◽  
Chemotherapeutic Agents ◽  
Intravesical Chemotherapy ◽  
Response To Treatment ◽  
Intravesical Therapy ◽  
Recurrence Rates ◽  
Urine Ph ◽  
Improve Drug Delivery

BACKGROUND: Nearly 70% of all new cases of bladder cancer are non-muscle invasive disease, the treatment for which includes transurethral resection followed by intravesical therapy. Unfortunately, recurrence rates approach 50% in part due to poor intravesical drug delivery. Hyperthermia is frequently used as an adjunct to intravesical chemotherapy to improve drug delivery and response to treatment. OBJECTIVE: To assess the solubility profile of intravesical chemotherapies under varying conditions of pH and temperature. METHODS: Using microplate laser nephelometry we measured the solubility of three intravesical chemotherapy agents (mitomycin C, gemcitabine, and cisplatin) at varying physical conditions. Drugs were assessed at room temperature (23°C), body temperature (37°C), and 43°C, the temperature used for hyperthermic intravesical treatments. To account for variations in urine pH, solubility was also investigated at pH 4.00, 6.00, and 8.00. RESULTS: Heat incrementally increased the solubility of all three drugs studied. Conversely, pH largely did not impact solubility aside for gemcitabine which showed slightly reduced solubility at pH 8.00 versus 6.00 or 4.00. Mitomycin C at the commonly used 2.0 mg/mL was insoluble at room temperature, but soluble at both 37 and 43°C. CONCLUSIONS: Hyperthermia as an adjunct to intravesical treatment would improve drug solubility, and likely drug delivery as some current regimens are insoluble without heat. Improvements in solubility also allow for testing of alternative administration regimens to improve drug delivery or tolerability. Further studies are needed to confirm that improvements in solubility result in increased drug delivery.

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