Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development

2021 ◽  
Vol 6 (65) ◽  
Author(s):  
Claudia Haftmann ◽  
Pascale Zwicky ◽  
Florian Ingelfinger ◽  
Florian Mair ◽  
Stefan Floess ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Thymic Epithelial Cell

scholarly journals Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones

Diabetes ◽  
2006 ◽  
Vol 55 (9) ◽  
pp. 2595-2601 ◽  
Author(s):  
Michael O. Palumbo ◽  
Dina Levi ◽  
Aziz Alami Chentoufi ◽  
Constantin Polychronakos
Keyword(s):  
Epithelial Cell ◽  
Thymic Epithelial Cell ◽  
Isolation And Characterization ◽  
Cell Clones ◽  
Medullary Thymic Epithelial Cell

Increased epithelial-free areas in thymuses with altered EphB-mediated thymocyte–thymic epithelial cell interactions

2017 ◽  
Vol 148 (4) ◽  
pp. 381-394 ◽  
Author(s):  
Javier García-Ceca ◽  
Sara Montero-Herradón ◽  
David Alfaro ◽  
Agustín G. Zapata
Keyword(s):  
Epithelial Cell ◽  
Cell Interactions ◽  
Thymic Epithelial Cell

scholarly journals Different Roles of a Rat Cortical Thymic Epithelial Cell LineIn Vitroon Thymocytes and Thymocyte Hybridoma Cells: Phagocytosis, Induction of Apoptosis, Nursing and Growth Promoting Activities

2002 ◽  
Vol 9 (2) ◽  
pp. 63-72 ◽  
Author(s):  
Dragana Vucevic ◽  
Miodrag Colic ◽  
Petar Popovic ◽  
Sonja Gašic
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Apoptotic Cell ◽  
Hybridoma Cells ◽  
Thymic Epithelial Cell ◽  
Apoptotic Cells ◽  
Th Cells ◽  
Nursing Activity ◽  
Induction Of Apoptosis ◽  
Stimulation Of

In this work, the interaction between a rat cortical thymic epithelial cell (TEC) line (R-TNC.1) with nursing activity and thymocytes as well as BWRT 8 thymocyte hybridoma (TH) cells has been studied. The R-TNC.1 cell line significantly bound thymocytes and TH. Binding was stronger during the first 30 min of cell incubation and was followed by a progressive deadhesion. Among adherent thymocytes the proportion of apoptotic cells increased with culture time which was a consequence of higher capacity of the line for binding of apoptotic than viable cells and induction of apoptosis in a subset of adherent thymocytes. Emperiopolesis activity of this thymic nurse cell (TNC) line was manifested by engulfment of thymocytes as well as TH cells. A subset of viable intra-TNC thymocytes has been triggered to die by apoptosis, whereas other internalized thymocytes have been stimulated to proliferate, as measured by an increase in the percentage of cells in mitosis and higher incorporation of bromodeoxyuridine (BrdU), in comparison to thymocytes cultivated alone. A significant stimulation of proliferation of engulfed TH cells was also observed. The R-TNC.1 cell line efficiently phagocytosed both apoptotic thymocytes and TH, and the process is followed by intra-TNC destruction of ingested cells. Cumulatively, these results suggest different role of the R-TNC.1 clone: phagocytosis of apoptotic cells; induction of apoptotic cell death in a subset of both bound and internalized thymocytes and stimulation of proliferation of a subset of intra-TNC thymocytes or TH cells.

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