scholarly journals Lighting a fire on the reef

2020 ◽  
Vol 5 (54) ◽  
pp. eabf0905
Author(s):  
Zhibin Zhang ◽  
Judy Lieberman
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Caspase 3 ◽  
Bacterial Pathogen ◽  
Related Research ◽  
Link Type ◽  
Research Article

Coral gasdermin E is cleaved by activated caspase-3 to induce pyroptosis, a form of inflammatory programmed cell death, in response to a bacterial pathogen (see the related Research Article by Jiang et al.).

P2X7R: The Achilles heel of follicular helper memory T cells

2020 ◽  
Vol 5 (45) ◽  
pp. eaba8097
Author(s):  
Jeffrey C. Nolz
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Memory T Cells ◽  
Related Research ◽  
Link Type ◽  
Follicular Helper ◽  
Research Article

Protecting TFH memory CD4+ T cells from NAD-induced cell death reveals both their longevity and plasticity (see related Research Article by Künzli et al.).

IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine

2019 ◽  
Vol 4 (42) ◽  
pp. eaaz6821
Author(s):  
Kai Kretzschmar ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Intestinal Injury ◽  
Intestinal Stem Cell ◽  
Related Research ◽  
Link Type ◽  
Research Article ◽  
Ifn Γ

IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article byTakashimaet al.).

scholarly journals Cell Death and Metabolic Stress in Gymnodinium catenatum Induced by Allelopathy

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 506
Author(s):  
Leyberth José Fernández-Herrera ◽  
Christine Johanna Band-Schmidt ◽  
Tania Zenteno-Savín ◽  
Ignacio Leyva-Valencia ◽  
Claudia Judith Hernández-Guerrero ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Protein Content ◽  
Caspase 3 ◽  
Cellular Stress ◽  
Allelopathic Effect ◽  
Sod Activity ◽  
Free Media ◽  
O2 Production ◽  
Gymnodinium Catenatum

Allelopathy between phytoplankton species can promote cellular stress and programmed cell death (PCD). The raphidophyte Chattonella marina var. marina, and the dinoflagellates Margalefidinium polykrikoides and Gymnodinium impudicum have allelopathic effects on Gymnodinium catenatum; however, the physiological mechanisms are unknown. We evaluated whether the allelopathic effect promotes cellular stress and activates PCD in G. catenatum. Cultures of G. catenatum were exposed to cell-free media of C. marina var. marina, M. polykrikoides and G. impudicum. The mortality, superoxide radical (O2●−) production, thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD) activity, protein content, and caspase-3 activity were quantified. Mortality (between 57 and 79%) was registered in G. catenatum after exposure to cell-free media of the three species. The maximal O2●− production occurred with C. marina var. marina cell-free media. The highest TBARS levels and SOD activity in G. catenatum were recorded with cell-free media from G. impudicum. The highest protein content was recorded with cell-free media from M. polykrikoides. All cell-free media caused an increase in the activity of caspase-3. These results indicate that the allelopathic effect in G. catenatum promotes cell stress and caspase-3 activation, as a signal for the induction of programmed cell death.

Region of caspase-3 activation and programmed cell death in the early development of the mouse forebrain

2003 ◽  
Vol 145 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Koko Urase ◽  
Yoriko Kouroku ◽  
Eriko Fujita ◽  
Takashi Momoi
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Early Development ◽  
Caspase 3

Illuminating the core of adaptive immunity—how the regulatory genome controls Rag chromatin dynamics

2020 ◽  
Vol 5 (51) ◽  
pp. eabd6427
Author(s):  
Xun Wang ◽  
Ellen V. Rothenberg
Keyword(s):  
Adaptive Immunity ◽  
Large Scale ◽  
Chromatin Dynamics ◽  
Related Research ◽  
The Core ◽  
Link Type ◽  
Research Article ◽  
Super Enhancer ◽  
Regulatory Genome ◽  
Topological Changes

E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation (see the related Research Article by Miyazaki et al.).

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