A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa

2022 ◽  
Vol 7 (67) ◽  
Author(s):  
Owen Jensen ◽  
Shubhanshi Trivedi ◽  
Jeremy D. Meier ◽  
Keke C. Fairfax ◽  
J. Scott Hale ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Production ◽  
Cell Subset ◽  
Mait Cells ◽  
Cell Responses ◽  
Follicular Helper ◽  
B Cell Responses ◽  
Mait Cell

We identify a MAIT cell subset expressing T follicular helper markers and show the ability of MAIT cells to support B cell responses in the mucosa.

Author response for "Dysregulation in B cell responses and T follicular helper cell function in ADA2 deficiency patients"

2020 ◽  
Author(s):  
Francesca Schena ◽  
Federica Penco ◽  
Stefano Volpi ◽  
Claudia Pastorino ◽  
Roberta Caorsi ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Function ◽  
Author Response ◽  
Helper Cell ◽  
Cell Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
B Cell Responses

scholarly journals The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

Immunity ◽  
2014 ◽  
Vol 41 (6) ◽  
pp. 1026-1039 ◽  
Author(s):  
Peter T. Sage ◽  
Alison M. Paterson ◽  
Scott B. Lovitch ◽  
Arlene H. Sharpe
Keyword(s):  
B Cell ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Cell Responses ◽  
Follicular Helper ◽  
B Cell Responses

scholarly journals Selective abrogation of antigen-specific human B cell responses by antigen-ricin conjugates.

1982 ◽  
Vol 156 (2) ◽  
pp. 634-639 ◽  
Author(s):  
D J Volkman ◽  
A Ahmad ◽  
A S Fauci ◽  
D M Neville
Keyword(s):  
T Cell ◽  
B Cell ◽  
Antibody Production ◽  
Specific Antibody ◽  
Mononuclear Cells ◽  
Pokeweed Mitogen ◽  
Cell Repertoire ◽  
Peripheral Blood Mononuclear ◽  
Cell Responses ◽  
B Cell Responses

The feasibility of selectively eliminating human antigen-specific B cell responses by treating cells in vitro with antigen covalently linked to a cell toxin was examined. Tetanus toxoid (TT) was conjugated to the toxin ricin via a thioether linkage. Peripheral blood mononuclear cells from recently immunized subjects were preincubated for 2 h with TT-ricin in the presence of lactose. Antigen was then removed, and the cells from recently immunized subjects were preincubated for 2 h with TT-ricin in the presence of lactose. Antigen was then removed, and the cells were stimulated with pokeweed mitogen to induce antibody production. TT-specific antibody production was completely abrogated by preincubation with TT-ricin but not by TT alone or a mixture of TT and ricin. In contrast, polyclonal immunoglobulin production was not diminished by TT-ricin. This selective abrogation was also seen when B cells alone were preincubated with TT-ricin and a source of T cell help was later provided. T cell blastogenic responses to TT remained intact after TT-ricin exposure. Thus, antigen-toxin conjugates are capable of selectively eliminating specific antibody-producing B cell clones, while leaving intact the remainder of the B cell repertoire.

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