It takes 2 TOXes to Tfh Tango

2019 ◽  
Vol 4 (42) ◽  
pp. eaba3067
Author(s):  
Jennifer S. Chen ◽  
Stephanie C. Eisenbarth
Keyword(s):  
Cell Development ◽  
Helper Cell ◽  
Follicular Helper ◽  
Epigenetic Remodeling ◽  
Transcriptional Changes ◽  
T Follicular Helper Cell

TOX and TOX2 promote T follicular helper cell development through transcriptional changes and epigenetic remodeling.

scholarly journals B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen

2014 ◽  
Vol 192 (7) ◽  
pp. 3166-3179 ◽  
Author(s):  
Jason S. Weinstein ◽  
Sarah A. Bertino ◽  
Sairy G. Hernandez ◽  
Amanda C. Poholek ◽  
Taylor B. Teplitzky ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Development ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
And Function

scholarly journals The Transcription Factor Twist1 Limits T Helper 17 and T Follicular Helper Cell Development by Repressing the Gene Encoding the Interleukin-6 Receptor α Chain

2013 ◽  
Vol 288 (38) ◽  
pp. 27423-27433 ◽  
Author(s):  
Duy Pham ◽  
Crystal C. Walline ◽  
Kristin Hollister ◽  
Alexander L. Dent ◽  
Janice S. Blum ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Critical Role ◽  
Cell Development ◽  
Receptor Expression ◽  
Helper Cell ◽  
T Helper 17 ◽  
Gene Encoding ◽  
Extracellular Milieu ◽  
Follicular Helper ◽  
T Follicular Helper Cell

Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression is a common mode of altering responses to the external environment. We identify the transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 demonstrate increased Th17 and T follicular helper cell development, early onset experimental autoimmune encephalomyelitis, and increased antigen-specific antibody responses. Thus, Twist1 has a critical role in limiting both cell-mediated and humoral immunity.

scholarly journals Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

Immunity ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 947-960 ◽  
Author(s):  
Steven M. Kerfoot ◽  
Gur Yaari ◽  
Jaymin R. Patel ◽  
Kody L. Johnson ◽  
David G. Gonzalez ◽  
...  
Keyword(s):  
B Cell ◽  
Germinal Center ◽  
Cell Development ◽  
Helper Cell ◽  
Follicular Helper ◽  
Germinal Center B Cell ◽  
T Follicular Helper Cell

scholarly journals The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

Immunity ◽  
2019 ◽  
Vol 51 (5) ◽  
pp. 826-839.e5 ◽  
Author(s):  
Wei Xu ◽  
Xiaohong Zhao ◽  
Xiaoshuang Wang ◽  
Han Feng ◽  
Mengting Gou ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chromatin Accessibility ◽  
Cell Development ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell
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