scholarly journals Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

2016 ◽  
Vol 1 (5) ◽  
pp. eaai7793-eaai7793 ◽  
Author(s):  
S. A. Long ◽  
J. Thorpe ◽  
H. A. DeBerg ◽  
V. Gersuk ◽  
J. A. Eddy ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Clinical Response ◽  
Cd8 T Cells ◽  
Onset Type ◽  
New Onset

scholarly journals Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes

2018 ◽  
Vol 20 (4) ◽  
pp. 293-307 ◽  
Author(s):  
Peter S. Linsley ◽  
Carla J. Greenbaum ◽  
Mario Rosasco ◽  
Scott Presnell ◽  
Kevan C. Herold ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Clinical Response ◽  
Peripheral Blood ◽  
Onset Type ◽  
New Onset

scholarly journals Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2319-2328
Author(s):  
Kaitlin R. Carroll ◽  
Eileen E. Elfers ◽  
Joseph J. Stevens ◽  
Jonathan P. McNally ◽  
David A. Hildeman ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Autoreactive T Cells ◽  
Onset Type ◽  
New Onset

scholarly journals One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

2021 ◽  
Author(s):  
Ada Admin ◽  
Teresa Rodriguez-Calvo ◽  
Lars Krogvold ◽  
Natalie Amirian ◽  
Knut Dahl-Jørgensen ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cells ◽  
Pancreatic Tissue ◽  
Cell Reactivity ◽  
Tissue Samples ◽  
Recent Onset ◽  
Onset Type

In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with short and long disease duration. The Diabetes Virus Detection (DiViD) study collected pancreatic tissue, by pancreatic tail resection, from living patients with recent-onset type 1 diabetes. These tissues have been extensively studied by the scientific community, but the autoreactive nature of the T cell infiltrate has remained unexplored. Our objective was to determine the number and localization of these cells in pancreas samples obtained through the DiViD study. Here, we demonstrate the presence of high frequencies of CD8+ T cells reactive against a highly relevant epitope derived from the preproinsulin signal peptide in pancreatic tissue samples from these donors. We additionally show the heterogeneity of islet distribution and CD8+ T cell infiltration. Our findings contribute to the current limited existing knowledge on T cell reactivity in the pancreas of recent onset type 1 diabetic donors, and indicate that antigen-specific therapies directed towards preproinsulin could have high clinical impact.

Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study

2017 ◽  
Vol 19 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Mahinder Paul ◽  
Darshan Badal ◽  
Neenu Jacob ◽  
Devi Dayal ◽  
Rakesh Kumar ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Adult Onset ◽  
Juvenile Onset ◽  
Onset Type ◽  
Follow Up Study

scholarly journals Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes

2017 ◽  
Vol 187 (3) ◽  
pp. 581-588 ◽  
Author(s):  
Enida Kuric ◽  
Peter Seiron ◽  
Lars Krogvold ◽  
Bjørn Edwin ◽  
Trond Buanes ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Adult Patients ◽  
Memory Cd8 T Cells ◽  
Recent Onset ◽  
Onset Type

2. Durable Efficacy of Alefacept in New-Onset Type 1 Diabetes: Evidence for Lasting Modulation of Effector and Regulatory T Cells (231-OR)

2015 ◽  
Vol 13 (3) ◽  
pp. 56-57
Author(s):  
Mark R. Rigby ◽  
Kristina M. Harris ◽  
Ashley Pinckney ◽  
Linda A. Dimeglio ◽  
Marc S. Rendell ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Regulatory T Cells ◽  
Onset Type ◽  
New Onset

scholarly journals Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183887 ◽  
Author(s):  
Hector M. Granados ◽  
Andrew Draghi ◽  
Naomi Tsurutani ◽  
Kyle Wright ◽  
Marina L. Fernandez ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Type 1 Diabetes ◽  
Programmed Cell Death ◽  
Onset Type ◽  
Programmed Cell Death 1 ◽  
New Onset

scholarly journals Human islet T cells are highly reactive to preproinsulin in type 1 diabetes

2021 ◽  
Vol 118 (41) ◽  
pp. e2107208118
Author(s):  
Amanda M. Anderson ◽  
Laurie G. Landry ◽  
Aimon A. Alkanani ◽  
Laura Pyle ◽  
Alvin C. Powers ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Messenger Rna ◽  
Human Islet ◽  
Organ Donors ◽  
Tissue Destruction ◽  
Separate Cohort ◽  
New Onset

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are major self-antigens targeted by T cells. We comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without T1D and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA. The frequency of preproinsulin-reactive T cells was significantly higher in T1D donors than nondiabetic donors and also differed by individual T1D donor, ranging from 3 to over 40%, with higher frequencies in T1D organ donors with HLA-A*02:01. Only T cells reactive to preproinsulin-related peptides isolated from T1D donors demonstrated potent autoreactivity. Reactivity to similar regions of preproinsulin was also observed in peripheral blood of a separate cohort of new-onset T1D patients. These findings have important implications for designing antigen-specific immunotherapies and identifying individuals that may benefit from such interventions.

scholarly journals Cutting Edge: Increased IL-17–Secreting T Cells in Children with New-Onset Type 1 Diabetes

2010 ◽  
Vol 185 (7) ◽  
pp. 3814-3818 ◽  
Author(s):  
Ashish K. Marwaha ◽  
Sarah Q. Crome ◽  
Constadina Panagiotopoulos ◽  
Kyra B. Berg ◽  
Huilian Qin ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cutting Edge ◽  
Onset Type ◽  
New Onset
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