Erratum for the Research Article “The genetic architecture of the human cerebral cortex,” by K. L. Grasby et al .

Science ◽  
2021 ◽  
Vol 374 (6566) ◽  
Keyword(s):  
Cerebral Cortex ◽  
Genetic Architecture ◽  
Human Cerebral Cortex ◽  
Research Article

C-fos, ERK1/2, MAP2, NOTCH1 Proteins Expression Patterns in Human Cerebral Cortex Neurons after Ischemic Stroke

2020 ◽  
Vol 75 (3) ◽  
pp. 226-233
Author(s):  
Svetlana P. Sergeeva ◽  
Aleksey V. Lyundup ◽  
Valery V. Beregovykh ◽  
Petr F. Litvitskiy ◽  
Aleksey A. Savin ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Ischemic Stroke ◽  
Expression Patterns ◽  
Immunohistochemical Method ◽  
Left Middle Cerebral Artery ◽  
Contralateral Hemisphere ◽  
Human Cerebral Cortex ◽  
Fos Protein ◽  
Urgent Task ◽  
Indirect Immunoperoxidase

Background. The search for protein (these include c-fos, ERK1/2, MAP2, NOTCH1) expression that provide neuroplasticity mechanisms of the cerebral cortex after ischemic stroke (IS) patterns is an urgent task. Aims to reveal c-fos, ERK1/2, MAP2, NOTCH1 proteins expression patterns in human cerebral cortex neurons after IS. Materials and methods. We studied 9 left middle cerebral artery (LMCA) IS patients cerebral cortex samples from 3 zones: 1 the zone adjacent to the necrotic tissue focus; 2 zone remote from the previous one by 47 cm; 3 zone of the contralateral hemisphere, symmetric to the IS focus. Control samples were obtained from 3 accident died people. Identification of targeted proteins NSE, c-fos, ERK1/2, MAP2, NOTCH1 was performed by indirect immunoperoxidase immunohistochemical method. Results. Moving away from the ischemic focus, there is an increase in the density of neurons and a decrease in the damaged neurons proportion, the largest share of c-fos protein positive neurons in zone 2, NOTCH1 positive neurons in zone 1, smaller fractions of ERK1/2 and MAP2 positive neurons compared to the control only in samples of zone 1. Conclusions. With the IS development, the contralateral hemisphere is intact tissue increased activation zone, while the zones 1 and 2 have pathological activation signs. In zone 1 of the range, the adaptive response of the tissue decreases, and in zone 2 it expands. Therefore, a key target for therapeutic intervention is zone 2.

scholarly journals VII. The exact histological localisation of the visual area of the human cerebral cortex

1900 ◽  
Vol 193 (185-193) ◽  
pp. 165-222 ◽  
Keyword(s):  
Cerebral Cortex ◽  
County Council ◽  
Visual Area ◽  
Human Cerebral Cortex ◽  
Human Cortex ◽  
Physiological Laboratory ◽  
Sensory Area ◽  
University College ◽  
Cortex Cerebri

The object of the present paper is to define by histological methods the exact limitations of the visuo-sensory area of the human cortex cerebri. The investigation to be described has occupied upwards of three years. It was commenced during the summer of 1896 in the pathological laboratory of the County Asylum, Rainhill, Lancashire; it was continued during the next three years in the physiological laboratory of Mason University College, Birmingham; and it has been completed in the pathological laboratory of the London County Council at Claybury. Owing to the remarkable facilities for research granted to workers in the last-named laboratory, it has been possible to bring this investigation to a much more rapid conclusion than would otherwise have been possible. A general summary of the paper follows this introduction, and it is succeeded for convenience of reference by a list of the sections into which the paper is divided.

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