Untangling the evolution of dengue viruses

Science ◽  
2021 ◽  
Vol 374 (6570) ◽  
pp. 941-942
Author(s):  
Pejman Rohani ◽  
John M. Drake
Keyword(s):  
Dengue Viruses

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

2019 ◽  
pp. e2037 ◽  
Author(s):  
Harapan Harapan ◽  
Alice Michie ◽  
Benediktus Yohan ◽  
Pei‐Yun Shu ◽  
Mudatsir Mudatsir ◽  
...  
Keyword(s):  
Systematic Review ◽  
Phylogenetic Analysis ◽  
Dengue Viruses

scholarly journals Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Maia A Rabaa ◽  
Yves Girerd-Chambaz ◽  
Kien Duong Thi Hue ◽  
Trung Vu Tuan ◽  
Bridget Wills ◽  
...  
Keyword(s):  
Genetic Epidemiology ◽  
Phase Iii ◽  
Envelope Gene ◽  
Dengue Vaccine ◽  
Virus Genotype ◽  
Pivotal Phase ◽  
Dengue Viruses ◽  
High Amino Acid ◽  
Phase Iii Trials ◽  
Trial Participants

This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9–16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution.

A dose-response study in mice of a tetravalent vaccine candidate composed of domain III-capsid proteins from dengue viruses

2017 ◽  
Vol 162 (8) ◽  
pp. 2247-2256 ◽  
Author(s):  
Iris Valdés ◽  
Ernesto Marcos ◽  
Edith Suzarte ◽  
Yusleidi Pérez ◽  
Enma Brown ◽  
...  
Keyword(s):  
Dose Response ◽  
Vaccine Candidate ◽  
Capsid Proteins ◽  
Dengue Viruses ◽  
Tetravalent Vaccine ◽  
Domain Iii ◽  
Dose Response Study

ISOLATION OF DENGUE VIRUSES IN MOSQUITO CELL CULTURES UNDER FIELD CONDITIONS

The Lancet ◽  
1978 ◽  
Vol 311 (8054) ◽  
pp. 48-49 ◽  
Author(s):  
M.W Race ◽  
R.A.J Fortune ◽  
Christiane Agostini ◽  
M.G.R Varma
Keyword(s):  
Cell Cultures ◽  
Field Conditions ◽  
Mosquito Cell ◽  
Dengue Viruses

scholarly journals The Incubation Periods of Dengue Viruses

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50972 ◽  
Author(s):  
Miranda Chan ◽  
Michael A. Johansson
Keyword(s):  
Dengue Viruses ◽  
Incubation Periods

scholarly journals Seroprevalence of Zika, Chikungunya and Dengue viruses in a rural area of northeastern Brazil

2020 ◽  
Vol 101 ◽  
pp. 245
Author(s):  
M.V. Francisco ◽  
B. Costa ◽  
B. Almeida ◽  
C. Santos ◽  
A.C. Casaes ◽  
...  
Keyword(s):  
Rural Area ◽  
Northeastern Brazil ◽  
Dengue Viruses

The Molecular Epidemiology of Dengue Viruses

1990 ◽  
pp. 293-315 ◽  
Author(s):  
Dennis W. Trent ◽  
Charles L. Manske ◽  
George E. Fox ◽  
May C. Chu ◽  
Srisakul C. Kliks ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Dengue Viruses
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