Host genetics influence the gut microbiome

Science ◽  
2021 ◽  
Vol 373 (6551) ◽  
pp. 159-160
Author(s):  
Liliana Cortes-Ortiz ◽  
Katherine R. Amato
Keyword(s):  
Gut Microbiome ◽  
Host Genetics

scholarly journals Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1181
Author(s):  
Alessandro Maglione ◽  
Miriam Zuccalà ◽  
Martina Tosi ◽  
Marinella Clerico ◽  
Simona Rolla
Keyword(s):  
Multiple Sclerosis ◽  
Environmental Factors ◽  
Lupus Erythematosus ◽  
Gut Microbiome ◽  
Complex Disease ◽  
Current Knowledge ◽  
Association Studies ◽  
Future Research ◽  
Genome Wide Association Studies ◽  
Host Genetics

As a complex disease, Multiple Sclerosis (MS)’s etiology is determined by both genetic and environmental factors. In the last decade, the gut microbiome has emerged as an important environmental factor, but its interaction with host genetics is still unknown. In this review, we focus on these dual aspects of MS pathogenesis: we describe the current knowledge on genetic factors related to MS, based on genome-wide association studies, and then illustrate the interactions between the immune system, gut microbiome and central nervous system in MS, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients. Finally, as the understanding of influence of host genetics on the gut microbiome composition in MS is in its infancy, we explore this issue based on the evidence currently available from other autoimmune diseases that share with MS the interplay of genetic with environmental factors (Inflammatory Bowel Disease, Rheumatoid Arthritis and Systemic Lupus Erythematosus), and discuss avenues for future research.

scholarly journals Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

2018 ◽  
Vol 29 (1-2) ◽  
pp. 63-79 ◽  
Author(s):  
Liang Chi ◽  
Bei Gao ◽  
Pengcheng Tu ◽  
Chih-Wei Liu ◽  
Jingchuan Xue ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Gut Microbiome ◽  
Host Genetics ◽  
Individual Susceptibility

The effect of host genetics on the gut microbiome

2016 ◽  
Vol 48 (11) ◽  
pp. 1407-1412 ◽  
Author(s):  
Marc Jan Bonder ◽  
Alexander Kurilshikov ◽  
Ettje F Tigchelaar ◽  
Zlatan Mujagic ◽  
Floris Imhann ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Host Genetics

scholarly journals The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

2019 ◽  
Author(s):  
Fengzhe Xu ◽  
Yuanqing Fu ◽  
Ting-yu Sun ◽  
Zengliang Jiang ◽  
Zelei Miao ◽  
...  
Keyword(s):  
Renal Function ◽  
Gut Microbiome ◽  
Genome Wide Association Study ◽  
Causal Effect ◽  
Complex Diseases ◽  
Disease Etiology ◽  
Host Genetics ◽  
Genome Wide ◽  
Host Genetic ◽  
Human Complex

AbstractThere is increasing interest about the interplay between host genetics and gut microbiome on human complex diseases, with prior evidence mainly derived from animal models. In addition, the shared and distinct microbiome features among human complex diseases remain largely unclear. We performed a microbiome genome-wide association study to identify host genetic variants associated with gut microbiome in a Chinese population with 1475 participants. We then conducted bi-directional Mendelian randomization analyses to examine the potential causal associations between gut microbiome and human complex diseases. We found that Saccharibacteria (also known as TM7 phylum) could potentially improve renal function by affecting renal function biomarkers (i.e., creatinine and estimated glomerular filtration rate). In contrast, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by the host genetics, had potential causal effect on gut microbiome. Further disease-microbiome feature analysis suggested that gut microbiome features revealed novel relationship among human complex diseases. These results suggest that different human complex diseases share common and distinct gut microbiome features, which may help re-shape our understanding about the disease etiology in humans.

scholarly journals The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases

2020 ◽  
Author(s):  
Fengzhe Xu ◽  
Yuanqing Fu ◽  
Tingyu Sun ◽  
Zengliang Jiang ◽  
Zelei Miao ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Lupus Erythematosus ◽  
Gut Microbiome ◽  
Genome Wide Association Study ◽  
Human Diseases ◽  
Host Genetics ◽  
Genome Wide ◽  
Disease Aetiology ◽  
Significant Heritability ◽  
Host Genetic

Abstract Background Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear.Results This analysis was based on a Chinese population with 1,475 participants. We estimated the SNP-based heritability, which suggested that Desulfovibrionaceae and Odoribacter had significant heritability estimates (0.456 and 0.476, respectively). We performed a microbiome genome-wide association study to identify host genetic variants associated with the gut microbiome. We then conducted bidirectional Mendelian randomization analyses to examine the potential causal associations between the gut microbiome and complex human diseases. We found that Saccharibacteria could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate. On the other hand, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by host genetics, had potential causal effects on the abundance of some specific gut microbiota. For example, atrial fibrillation increased the abundance of Burkholderiales and Alcaligenaceae and decreased the abundance of Lachnobacterium, Bacteroides coprophilus, Barnesiellaceae, undefined genus in family Veillonellaceae and Mitsuokella. Further disease-microbiome feature analysis suggested that systemic lupus erythematosus and chronic myeloid leukaemia shared common gut microbiome features.Conclusions These results suggest that different complex human diseases share common and distinct gut microbiome features, which may help reshape our understanding of disease aetiology in humans.

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