‘Total game changer’: Pinpointing gene activity in tissues is aiding studies of COVID-19, Alzheimer’s

Science ◽  
2021 ◽  
Author(s):  
Elizabeth Pennisi
Keyword(s):  
Gene Activity ◽  
Game Changer

Introduction

1978 ◽  
Vol 36 (3) ◽  
pp. 543-544
Author(s):  
W. Bernard
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Nucleic Acid ◽  
Gene Mapping ◽  
Molecular Genetics ◽  
Cell Biology ◽  
Gene Activity ◽  
Close Connection ◽  
Basic Information ◽  
Simple Systems

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

Game Changer

2011 ◽  
Vol 20 (1) ◽  
pp. 17-18 ◽  
Author(s):  
Lateef McLeod
Keyword(s):  
San Francisco ◽  
Mobile Technology ◽  
Technology Tools ◽  
Communication Challenges ◽  
Communication Needs ◽  
Game Changer

Abstract Individuals with significant communication challenges need to communicate across many different venues. The author, from the perspective of an individual who uses AAC, discusses the strengths and weaknesses of both traditional AAC technologies and new mobile AAC technologies. He describes how access to AAC has allowed him to fulfill his dreams as a presenter and writer. He successfully manages a blog in San Francisco, writes grants, and has published his first book of poetry. Not one AAC device fits all of his communication needs; however, access to mobile technology tools has increased his flexibility across environments and given him another successful tool for communication.

The ACO Final Rule – a Game Changer for Primary Care?

2011 ◽  
Vol 44 (20) ◽  
pp. 7
Author(s):  
JULIAN D. “BO” BOBBITT
Keyword(s):  
Primary Care ◽  
Final Rule ◽  
Game Changer

Schlaganfallbehandlung: Künstliche Intelligenz als Game-Changer

2018 ◽  
Vol 23 (11) ◽  
pp. 32-34
Author(s):  
Dietmar Frey
Keyword(s):  
Künstliche Intelligenz ◽  
Game Changer

Jedes Jahr erleiden rund 270 000 Deutsche einen Schlaganfall. Obwohl die Ursachen eines Schlaganfalls sehr unterschiedlich sind, bilden die aktuellen Richtlinien individuelle Eigenschaften des Patienten nicht ausreichend ab. Forscher der Berliner Charité suchen Abhilfe und entwickeln mithilfe von künstlicher Intelligenz personalisierte Vorhersageanalysen für die Schlaganfalltherapie und Prävention.

Explaining Brexit North and South of the Border

2017 ◽  
Vol 26 (4) ◽  
pp. 391-410 ◽  
Author(s):  
David McCrone
Keyword(s):  
Turning Point ◽  
Social Values ◽  
Demographic Characteristics ◽  
Social Surveys ◽  
Clear Cut ◽  
Major Turning Point ◽  
Scottish Independence ◽  
North And South ◽  
Scottish Politics ◽  
Game Changer

The Brexit referendum in 2016 was a major turning-point in British and Scottish politics, reflected in a majority for Leave in England, but for Remain in Scotland. This article uses the British and Scottish Social Surveys for 2016 to explain Scottish-English differences, and finds that there were broad similarities in terms of social and demographic characteristics, and in terms of social values (‘authoritarians’ voting for Leave). Being ‘English’, however, was much more significant than being ‘Scottish’ in accounting for Brexit vote. The association between Brexit vote and constitutional preferences, notably voting intention in a future Scottish Independence Referendum, is far less clear-cut. Brexit promises to be a political game-changer, but in ways which are complex and unpredictable.

Direct Cash Transfer- A Real Game Changer

2012 ◽  
Vol 2 (1) ◽  
pp. 12-13
Author(s):  
Dinesh Dadasaheb Borse ◽  
◽  
Dr. D. M. Gujarathi Dr. D. M. Gujarathi
Keyword(s):  
Cash Transfer ◽  
Game Changer

Cancer of the vulva: genetic aspects of pathogenesis

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (4) ◽  
pp. 9-11 ◽  
Author(s):  
V V Sobolev ◽  
Z A Nevozinskaya ◽  
A G Soboleva ◽  
I M Korsunskaya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nucleotide Sequence ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Somatic Mutations ◽  
Genetic Research ◽  
Tp53 Gene ◽  
Gene Activity ◽  
Genetic Changes ◽  
Methylation Of Dna

The review is devoted to genetic research in cancer of the vulva. In genetic changes, the mutation irreversibly changes the nucleotide sequence of DNA, or the number of copies of chromosomes changes per cell. In epigenetics, the nucleotide sequence remains unchanged, but gene activity is regulated by methylation of DNA or modification of histones. Most of the studies analyzed are devoted to the study of mutations in the TP53 gene. Many studies indicate that somatic mutations are more common in HPV-negative than in HPV-positive patients. Epigenetic studies in the main devoted to hypermethylation. The gene CDKN2A is most often studied in epigenetic terms. For most of the studied genes, hypermethylation occurs more often in squamous cell carcinoma of the vulva than in the precursors.

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