Strategies for durable β cell replacement in type 1 diabetes

Science ◽  
2021 ◽  
Vol 373 (6554) ◽  
pp. 516-522 ◽  
Author(s):  
Todd M. Brusko ◽  
Holger A. Russ ◽  
Cherie L. Stabler
Keyword(s):  
Type 1 Diabetes ◽  
Cell Biology ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Β Cell ◽  
Cell Replacement ◽  
Site Design ◽  
Immunomodulatory Therapies

Technological advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for people with type 1 diabetes. However, these efforts fall short of replicating the exquisite metabolic control provided by native islets. We examine the integrated advancements in islet cell replacement and immunomodulatory therapies that are coalescing to enable the restoration of endogenous glucose regulation. We highlight advances in stem cell biology and graft site design, which offer innovative sources of cellular material and improved engraftment. We also cover cutting-edge approaches for preventing allograft rejection and recurrent autoimmunity. These insights reflect a growing understanding of type 1 diabetes etiology, β cell biology, and biomaterial design, together highlighting therapeutic opportunities to durably replace the β cells destroyed in type 1 diabetes.

Can Innovative Technologies Overcome HbA1c Disparity for African-American Youth with Type 1 Diabetes?

2021 ◽  
pp. 193229682110213
Author(s):  
Stuart Chalew ◽  
Alan M. Delamater ◽  
Sonja Washington ◽  
Jayalakshmi Bhat ◽  
Diane Franz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Racial Disparity ◽  
Diabetes Management ◽  
New Technology ◽  
African American Youth ◽  
Glucose Monitoring ◽  
Supportive Role

Achieving normal or near-normal glycemic control as reflected by HbA1c levels in patients with type 1 diabetes (T1D) is important for preventing the development and progression of chronic complications. Despite delineation and dissemination of HbA1c management targets and advances in insulin pharmacology, insulin delivery systems, and glucose monitoring, the majority of children with T1D do not achieve HbA1c goals. In particular, African Americans are more likely not to reach HbA1c goals and have persistently higher HbA1c than Non-Hispanic Whites. Availability of pumps and other technology has not eliminated the disparity in HbA1c. Multiple factors play a role in the persisting racial disparity in HbA1c outcome. The carefully designed application and deployment of new technology to help the patient/family and facilitate the supportive role of the diabetes management team may be able to overcome racial disparity in glycemic outcome and improve patient quality of life.

scholarly journals From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

Islets ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. e28778 ◽  
Author(s):  
Aarthi Maganti ◽  
Carmella Evans-Molina ◽  
Raghavendra Mirmira
Keyword(s):  
Type 1 Diabetes ◽  
Cell Biology ◽  
Β Cell

scholarly journals Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes

2016 ◽  
Vol 5 (10) ◽  
pp. 1338-1344 ◽  
Author(s):  
Daniel Pipeleers ◽  
Thomas Robert ◽  
Ines De Mesmaeker ◽  
Zhidong Ling
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Human Stem Cell ◽  
Β Cell ◽  
Cell Replacement ◽  
Concise Review

136-OR: Nocturnal Hypoglycemia Prevention Strategies Used by People with Type 1 Diabetes According to Their Insulin Delivery and Blood Glucose Monitoring Technology

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 136-OR
Author(s):  
MERYEM K. TALBO ◽  
VIRGINIE MESSIER ◽  
KATHERINE DESJARDINS ◽  
RÉMI RABASA-LHORET ◽  
ANNE-SOPHIE BRAZEAU ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Glucose Monitoring ◽  
Insulin Delivery ◽  
Blood Glucose Monitoring ◽  
Prevention Strategies ◽  
Monitoring Technology ◽  
Nocturnal Hypoglycemia

scholarly journals Comparison between adherence assessments and blood glucose monitoring measures to predict A1c in type 1 diabetes

2015 ◽  
Vol 7 (S1) ◽  
Author(s):  
Gabriela Heiden Teló ◽  
Martina Schaan de Souza ◽  
Thaís Sturmer Andrade ◽  
Beatriz D'Agord Schaan
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring

scholarly journals β-Cell replacement as a treatment for type 1 diabetes: an overview of possible cell sources and current axes of research

2016 ◽  
Vol 18 ◽  
pp. 137-143 ◽  
Author(s):  
A. Vieira ◽  
M. Courtney ◽  
N. Druelle ◽  
F. Avolio ◽  
T. Napolitano ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Β Cell ◽  
Cell Replacement ◽  
Cell Sources
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