Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus

Science ◽  
2021 ◽  
Vol 373 (6557) ◽  
pp. 918-922
Author(s):  
Yongkun Chen ◽  
Laura Graf ◽  
Tao Chen ◽  
Qijun Liao ◽  
Tian Bai ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Rare Variant ◽  
H7n9 Influenza Virus ◽  
H7n9 Influenza

Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient

2019 ◽  
Vol 170 ◽  
pp. 104564
Author(s):  
Junxin Li ◽  
Yang Yang ◽  
Min Wang ◽  
Xiaohu Ren ◽  
Zheng Yang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Infected Patient ◽  
Human Antibody ◽  
Rapid Isolation ◽  
H7n9 Influenza Virus ◽  
H7n9 Influenza

scholarly journals Ramsay Hunt Syndrome in a Patient with H7N9 Influenza Virus Infection

2015 ◽  
Vol 128 (3) ◽  
pp. 417-418
Author(s):  
Jia-Jia Wang ◽  
Jian-An Huang ◽  
Da-Guo Zhao ◽  
Jun Jin ◽  
Sheng-Lan Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Ramsay Hunt Syndrome ◽  
Hunt Syndrome ◽  
H7n9 Influenza Virus ◽  
H7n9 Influenza

scholarly journals Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates

2015 ◽  
Vol 59 (8) ◽  
pp. 4962-4973 ◽  
Author(s):  
Yasushi Itoh ◽  
Shintaro Shichinohe ◽  
Misako Nakayama ◽  
Manabu Igarashi ◽  
Akihiro Ishii ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Cynomolgus Macaque ◽  
Influenza Virus Infection ◽  
Influenza Viruses ◽  
H7n9 Virus ◽  
Macaque Model ◽  
H7n9 Influenza Virus ◽  
Number Of Patients ◽  
H7n9 Influenza

ABSTRACTThe number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a patient in a cynomolgus macaque model. NA inhibitors (oseltamivir and peramivir) barely reduced the total virus amount because of the emergence of resistant variants with R289K or I219T in NA [residues 289 and 219 in N9 of A/Anhui/1/2013 (H7N9) correspond to 292 and 222 in N2, respectively] in three of the six treated macaques, whereas subcutaneous immunization of an inactivated vaccine derived from A/duck/Mongolia/119/2008 (H7N9) prevented propagation of A/Anhui/1/2013 (H7N9) in all vaccinated macaques. The percentage of macaques in which variant H7N9 viruses with low sensitivity to the NA inhibitors were detected was much higher than that of macaques in which variant H5N1 highly pathogenic influenza virus was detected after treatment with one of the NA inhibitors in our previous study. The virus with R289K in NA was reported in samples from human patients, whereas that with I219T in NA was identified for the first time in this study using macaques, though no variant H7N9 virus was reported in previous studies using mice. Therefore, the macaque model enables prediction of the frequency of emerging H7N9 virus resistant to NA inhibitorsin vivo. Since H7N9 strains resistant to NA inhibitors might easily emerge compared to other influenza viruses, monitoring of the emergence of variants is required during treatment of H7N9 influenza virus infection with NA inhibitors.

scholarly journals Role of Poultry in the Spread of Novel H7N9 Influenza Virus in China

2014 ◽  
Vol 88 (10) ◽  
pp. 5381-5390 ◽  
Author(s):  
M. J. Pantin-Jackwood ◽  
P. J. Miller ◽  
E. Spackman ◽  
D. E. Swayne ◽  
L. Susta ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H7n9 Influenza Virus ◽  
H7n9 Influenza
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