Not wearing masks to protect against coronavirus is a ‘big mistake,’ top Chinese scientist says

Science ◽  
2020 ◽  
Author(s):  
Jon Cohen
Keyword(s):  
Chinese Scientist

scholarly journals Repurposing Anti-Malaria Phytomedicine Artemisinin as a COVID-19 Drug

2021 ◽  
Vol 12 ◽  
Author(s):  
Fatih M. Uckun ◽  
Saran Saund ◽  
Hitesh Windlass ◽  
Vuong Trieu
Keyword(s):  
High Risk ◽  
Health Condition ◽  
Infection Process ◽  
Spike Protein ◽  
Organ Injury ◽  
Cytokine Storm ◽  
Infection Cycle ◽  
Chinese Scientist ◽  
Anti Inflammatory ◽  
Post Entry

Artemisinin is an anti-inflammatory phytomedicine with broad-spectrum antiviral activity. Artemisinin and its antimalarial properties were discovered by the Chinese scientist Tu Youyu, who became one of the laureates of the 2015 Nobel Prize in Physiology or Medicine for this breakthrough in tropical medicine. It is a commonly used anti-malaria drug. Artemisinin has recently been repurposed as a potential COVID-19 drug. Its documented anti-SARS-CoV-2 activity has been attributed to its ability to inhibit spike-protein mediated and TGF-β-dependent early steps in the infection process as well as its ability to disrupt the post-entry intracellular events of the SARS-CoV-2 infection cycle required for viral replication. In addition, Artemisinin has anti-inflammatory activity and reduces the systemic levels of inflammatory cytokines that contribute to cytokine storm and inflammatory organ injury in high-risk COVID-19 patients. We postulate that Artemisinin may prevent the worsening of the health condition of patients with mild-moderate COVID-19 when administered early in the course of their disease.

Research News

2001 ◽  
Vol 05 (19) ◽  
pp. 478-479
Keyword(s):  
Breast Cancer ◽  
Human Chromosome ◽  
Cancer Drug ◽  
Chinese Scientist ◽  
Complete Mapping

Mimicking Pregnancy to Develop Anti-Breast Cancer Drug in Singapore. Chinese Scientist in US to Treat Cataract through Genome Studies. First Cloned Calf Born in Taiwan. Chinese Scientists Complete Mapping of No. 3 Human Chromosome.

Chinese scientist jailed over theft of hybrid corn

Science ◽  
2016 ◽  
Vol 354 (6309) ◽  
pp. 160-161
Author(s):  
M. Hvistendahl
Keyword(s):  
Chinese Scientist ◽  
Hybrid Corn

scholarly journals Severe hypokalaemia and paralysis in a Chinese scientist

2001 ◽  
Vol 16 (7) ◽  
pp. 1503-1505
Author(s):  
Eva Bettina Zinngrebe ◽  
Jürgen Steffgen ◽  
Gerhard Anton Müller ◽  
Frank Strutz
Keyword(s):  
Chinese Scientist

scholarly journals Chinese scientist arrested for entrepreneurial spirit

Nature ◽  
1992 ◽  
Vol 359 (6398) ◽  
pp. 763-763
Author(s):  
You Qin Li
Keyword(s):  
Chinese Scientist ◽  
Entrepreneurial Spirit

How the Chinese Scientist Survives

Science ◽  
1972 ◽  
Vol 177 (4052) ◽  
pp. 864-866 ◽  
Author(s):  
L. A. Orleans
Keyword(s):  
Chinese Scientist

scholarly journals Discovery of Potential Plant-derived Iradoides with COVID-19 Mpro in silico

2021 ◽  
Author(s):  
Mohd Rehan
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
In Silico ◽  
Binding Energies ◽  
Small Class ◽  
Chinese Scientist ◽  
Autodock Vina ◽  
Discovery Studio ◽  
Traditional System ◽  
Potential Target

Abstract Iradoides are a small class of plant derived natural products, which used in traditional system of medicine such as Unani, Tibetan, Ayurveda, Siddha, and Chinese medicine. The several diverse types of iradoides have been isolated from many parts of the plant such as root, leaves, flowers, stem, rhizomes, bark, and seed. Here, we used bioactive iradoides to know the potency against COVID-19 Mpro. The COVID-19 Mpro is a potential target of the drug, which identified by Chinese scientist (published manuscript in Nature on June 2020). From several studies, we found that many natural products such as flavonoids, saponins, steroids, terpenoids, and synthesized compounds have been used on this target (COVID-19 Mpro). We screened a series of iradoides against COVID-19 Mpro (PDB ID: 6LU7) by using many docking software as BIOVIA Discovery Studio 2017 R2, Chimera 1.13.1, Auto Dock Tools-1.5.6, AutoDock Vina to known best inhibitor against COVID-19 Mpro. According to obtained results, 6′-O-trans-feruloylnegundoside, p-hydroxybenzoyl-6′-O-trans-caffeoylgardoside, 2′-O-p-hydroxybenzoyl gardoside, 6-deoxyharpagide, reptoside show binding energies -8.1, -8.3, -8.2, -7.0, and -7.1 Kcal/mol, respectively. From this study, we found that all iradoides show more potency on COVID-19 Mpro when compared with Chloroquine and hydroxychloroquine. The Chloroquine and hydroxychloroquine used as standards for comparison. From the results of this study, we found that iradoides may be useful in the treatment of COVID-19 patients.

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