scholarly journals MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

Science ◽  
2020 ◽  
Vol 370 (6513) ◽  
pp. 241-247 ◽  
Author(s):  
Anna Bruchez ◽  
Ky Sha ◽  
Joshua Johnson ◽  
Li Chen ◽  
Caroline Stefani ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Viral Entry ◽  
Ebola Virus ◽  
Viral Infections ◽  
Gene Activation ◽  
Class Ii ◽  
Cellular Mechanisms ◽  
Class Ii Transactivator ◽  
Additional Function ◽  
Mhc Class Ii Transactivator

Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our poor understanding of the cellular mechanisms that block viral infections. Using a transposon-mediated gene-activation screen in human cells, we identify that the major histocompatibility complex (MHC) class II transactivator (CIITA) has antiviral activity against EBOV. CIITA induces resistance by activating expression of the p41 isoform of invariant chain CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the Ebola glycoprotein. We further show that CD74 p41 can block the endosomal entry pathway of coronaviruses, including SARS-CoV-2. These data therefore implicate CIITA and CD74 in host defense against a range of viruses, and they identify an additional function of these proteins beyond their canonical roles in antigen presentation.

scholarly journals The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1

Retrovirology ◽  
2015 ◽  
Vol 12 (S1) ◽  
Author(s):  
Greta Forlani ◽  
Rawan Abdallah ◽  
Luisa Guidali ◽  
Roberto S Accolla ◽  
Giovanna Tosi
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo

2017 ◽  
Vol 47 (8) ◽  
pp. 1317-1323 ◽  
Author(s):  
David A. Anderson ◽  
Gary E. Grajales-Reyes ◽  
Ansuman T. Satpathy ◽  
Carlos E. Vasquez Hueichucura ◽  
Theresa L. Murphy ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator

scholarly journals Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148753 ◽  
Author(s):  
Yves B. Beaulieu ◽  
Jorge A. Leon Machado ◽  
Sylvain Ethier ◽  
Luc Gaudreau ◽  
Viktor Steimle
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
N Terminus ◽  
Promoter Recruitment ◽  
Mhc Class Ii Transactivator

scholarly journals Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

Immunity ◽  
1996 ◽  
Vol 4 (2) ◽  
pp. 167-178 ◽  
Author(s):  
Cheong-Hee Chang ◽  
Sylvie Guerder ◽  
Soon-Cheol Hong ◽  
Willem van Ewijk ◽  
Richard A Flavell
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Class Ii Transactivator ◽  
Tissue Specific ◽  
Mhc Class Ii Transactivator

scholarly journals Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA

Immunity ◽  
1997 ◽  
Vol 6 (5) ◽  
pp. 591-600 ◽  
Author(s):  
Brian K Martin ◽  
Keh-Chuang Chin ◽  
John C Olsen ◽  
Cheryl A Skinner ◽  
Anup Dey ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class I ◽  
Class Ii Transactivator ◽  
Mhc Class Ii Transactivator
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