scholarly journals Vaccination strategies to enhance immunity in neonates

Science ◽  
2020 ◽  
Vol 368 (6491) ◽  
pp. 612-615 ◽  
Author(s):  
Tobias R. Kollmann ◽  
Arnaud Marchant ◽  
Sing Sing Way
Keyword(s):  
Neonatal Infections ◽  
Knowledge Gaps ◽  
Alternative Strategies ◽  
Maternal Immunity ◽  
Vaccination Strategies ◽  
Specific Immunity ◽  
Neonatal Immunity ◽  
Protective Antibodies ◽  
Window Of Vulnerability

Neonates are particularly susceptible to infection. This vulnerability occurs despite their responsiveness to most vaccines. However, current vaccines do not target the pathogens responsible for most of the severe neonatal infections, and the time it takes to induce protective pathogen-specific immunity after vaccination limits protection in the first days to weeks of life. Alternative strategies include using vaccines to broadly stimulate neonatal immunity in a pathogen-agnostic fashion or vaccinating women during pregnancy to induce protective antibodies that are vertically transferred to offspring within their window of vulnerability. Protection may be further improved by integrating these approaches, namely vaccinating the neonate under the cover of vertically transferred maternal immunity. The rationale for and knowledge gaps related to each of these alternatives are discussed.

scholarly journals COVID-19: a review of current knowledge regarding exposure, quarantine, isolation and other preventive measures

2021 ◽  
Vol 8 ◽  
pp. 204993612110320
Author(s):  
Robert Rosolanka ◽  
Andres F. Henao-Martinez ◽  
Larissa Pisney ◽  
Carlos Franco-Paredes ◽  
Martin Krsak
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Response ◽  
Preventive Measures ◽  
Current Knowledge ◽  
Therapeutic Options ◽  
Exposure Control ◽  
Knowledge Gaps ◽  
Vaccination Strategies ◽  
Speed Up

Deeper understanding of the spread, morbidity, fatality, and development of immune response associated with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is necessary in order to establish an appropriate epidemiological and clinical response. Exposure control represents a key part of the combat against COVID-19, as the effectiveness of current therapeutic options remains partial. Since the preventive measures have not been sufficiently able to slow down this pandemic, in this article we explore some of the pertinent knowledge gaps, while overall looking to effective vaccination strategies as a way out. Early on, such strategies may need to rely on counting the convalescents as protected in order to speed up the immunization of the whole population.

scholarly journals An SVEICRD model for assessing the impact of the lock-down intervention and vaccination strategies on the spread of COVID-19

2021 ◽  
Author(s):  
Idil Aydin ◽  
Aysun Bozanta ◽  
Mucahit Cevik ◽  
Ayse Basar
Keyword(s):  
Numerical Study ◽  
Vaccination Strategy ◽  
Alternative Strategies ◽  
Vaccination Strategies ◽  
The Uk ◽  
Fourth Wave ◽  
The Impact ◽  
Death Cases

In this research, we aim to forecast the trajectory of the COVID-19 pandemic in terms of the number of exposed, infected, vaccinated, hospitalized, recovered, and dead people, and observe the effects of different vaccination strategies on the spread of the COVID-19. We simulate the ongoing trajectory of the outbreak in three countries, namely, Canada, the UK, and Israel using the susceptible - vaccinated - exposed - infected - critical - recovered - dead (SVEICRD) model. We consider two vaccination strategies and investigate their effects on the number of exposed and death cases. We perform an extensive numerical study to assess the implications of different strategies and spread scenarios. Our findings confirm that the fourth wave has begun in all three countries, and already reached its peak. We observe that starting second dose vaccination as early as possible is the most effective in mitigating the spread of COVID-19, although it does require more vaccination supply than the alternative strategies. Our results show that the SVEICRD model successfully forecasts the changing number of people in each compartment and the vaccination strategy significantly impacts the trajectory of the outbreak.

Patients' Knowledge Gaps May Hamper Breast Ca Follow-Up

Ob Gyn News ◽  
2011 ◽  
Vol 46 (4) ◽  
pp. 10
Author(s):  
SUSAN LONDON
Keyword(s):  
Knowledge Gaps

Individual Differences in Mental Rotation

2013 ◽  
Vol 60 (3) ◽  
pp. 164-171 ◽  
Author(s):  
Peter Khooshabeh ◽  
Mary Hegarty ◽  
Thomas F. Shipley
Keyword(s):  
Individual Differences ◽  
Mental Rotation ◽  
Response Times ◽  
Task Demands ◽  
Mental Rotation Task ◽  
Imagery Ability ◽  
Alternative Strategies

Two experiments tested the hypothesis that imagery ability and figural complexity interact to affect the choice of mental rotation strategies. Participants performed the Shepard and Metzler (1971) mental rotation task. On half of the trials, the 3-D figures were manipulated to create “fragmented” figures, with some cubes missing. Good imagers were less accurate and had longer response times on fragmented figures than on complete figures. Poor imagers performed similarly on fragmented and complete figures. These results suggest that good imagers use holistic mental rotation strategies by default, but switch to alternative strategies depending on task demands, whereas poor imagers are less flexible and use piecemeal strategies regardless of the task demands.

Knowledge Gaps in Postpartum BP Management

2005 ◽  
Vol 35 (3) ◽  
pp. 53
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Knowledge Gaps
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