Study of marathon runners reveals a ‘hard limit’ on human endurance

Science ◽  
2019 ◽  
Author(s):  
Michael Price
Keyword(s):  
Marathon Runners ◽  
Hard Limit

The Increased Sensitivity of Platelets to Prostacyclin in Marathon Runners

1984 ◽  
Vol 51 (03) ◽  
pp. 385-387 ◽  
Author(s):  
Clive J Dix ◽  
David G Hassall ◽  
K Richard Bruckdorfer
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Platelet Aggregation ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Platelet Rich Plasma ◽  
Marathon Runners ◽  
Inhibition Of Platelet Aggregation ◽  
Increased Sensitivity ◽  
Membrane Bound

SummaryPlatelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners’ platelets were much more sensitive to inhibition by prostacyclin, a prostaglandin synthesized by endothelial cells. It appeared that this effect was due to a greater activity in the platelets of the membrane-bound adenylate cyclase enzyme which generates intracellular cyclic AMP. Cyclic AMP production is known to be stimulated by prostacyclin and to cause the inhibition of platelet aggregation. The results indicate another possible protective effect of exercise against cardiovascular disease which is independent of the known changes in lipoprotein concentrations previously observed in athletes.

Risk Stratification for Coronary Artery Disease in Marathon Runners

2008 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Stefan Möhlenkamp ◽  
Raimund Erbel ◽  
Gerd Heusch ◽  
◽  
◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Marathon Runners ◽  
Artery Disease

Development of Pseudoanemia in Marathon Runners During a 20-Day Road Race

JAMA ◽  
1981 ◽  
Vol 246 (11) ◽  
pp. 1215 ◽  
Author(s):  
Rudolph H. Dressendorfer
Keyword(s):  
Marathon Runners ◽  
Road Race

scholarly journals Prevalence of pathological FFRCT values without coronary artery stenosis in an asymptomatic marathon runner cohort

2021 ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Greulich ◽  
Jens Kuebler ◽  
Florian Hagen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Fractional Flow ◽  
Marathon Runners ◽  
Coronary Artery Segment ◽  
Relevance Evaluation ◽  
Artery Segment ◽  
Distal Vessel

Abstract Objectives To evaluate computed tomography fractional flow reserve (FFRCT) values in distal parts of the coronaries in an asymptomatic cohort of marathon runners without any coronary stenosis for potentially false-positive values. Methods Ninety-eight asymptomatic male marathon runners (age 53 ± 7 years) were enrolled in a prospective monocentric study and underwent coronary computed tomography angiography (CCTA). CCTA data were analyzed for visual coronary artery stenosis. FFRCT was evaluated in 59 participants without coronary artery stenosis in proximal, mid, and distal coronary sections using an on-site software prototype. Results In participants without coronary artery stenosis, abnormal FFRCT values ≤ 0.8 in distal segments were found in 22 participants (37%); in 19 participants in the LAD; in 5 participants in the LCX; and in 4 participants in the RCA. Vessel diameters in participants with FFRCT values > 0.80 compared to ≤ 0.80 were 1.6 ± 0.3 mm versus 1.5 ± 0.3 mm for distal LAD (p = 0.025), 1.8 ± 0.3 mm versus 1.6 ± 0.5 mm for distal LCX (p = 0.183), and 2.0 ± 0.4 mm versus 1.5 ± 0.2 mm for distal RCA (p < 0.001). Conclusions Abnormal FFRCT values of ≤ 0.8 frequently occurred in distal coronary segments in subjects without any anatomical coronary artery stenosis. This effect is only to some degree explainable by small distal vessel diameters. Therefore, the validity of hemodynamic relevance evaluation using FFRCT in distal coronary artery segment stenosis is reduced. Key Points • Abnormal FFRCT values (≤ 0.8) occurred in over a third of the subjects in the distal LAD despite the absence of coronary artery stenosis.. • Therefore, the validity of hemodynamic relevance evaluation in distal coronary artery segment stenosis is reduced. • Decision-making based on abnormal FFRCT values in distal vessel sections should be performed with caution and only in combination with visual assessment of the grade of stenosis..

scholarly journals The use and meanings of prayer by recreational marathon runners

2019 ◽  
Vol 51 (2) ◽  
pp. 147-164
Author(s):  
Mary Katherine Huffman ◽  
Jennifer L. Etnier
Keyword(s):  
Marathon Runners

scholarly journals Validity of Recreational Marathon Runners’ Self-Reported Anthropometric Data

2020 ◽  
Vol 127 (6) ◽  
pp. 1068-1078
Author(s):  
Pantelis T. Nikolaidis ◽  
Beat Knechtle
Keyword(s):  
Body Mass ◽  
Assessment Method ◽  
Fat Percentage ◽  
Anthropometric Data ◽  
Anthropometric Measures ◽  
Marathon Runners ◽  
Present Sample ◽  
Large Samples ◽  
Anthropometric Characteristics ◽  
Recreational Runners

While studies on large samples of recreational runners have often relied on participants’ self-reported height and body mass, the validity of these data have not been investigated for this population. Hence, this study sought to examine the validity of self-reported anthropometric measures among recreational marathon runners. Female ( n = 32) and male ( n = 135) recreational marathon runners were requested to estimate their body mass and height (and we calculated their self-reported body mass index [BMI]), after which we took actual measures of their body mass and height and calculated their actual BMI. Participants’ self-reported values underestimated their actual body mass by 0.65 kg ( p < .001, η2 = 0.222) and their actual BMI by 0.35 kg ⋅ m−2 ( p < .001, η2 = 0.245). There was a significant Assessment Method × Sex Interaction for both body mass ( p = .019, η2 = 0.033) and BMI ( p = .017, η2 = 0.034), as women underestimated body mass values more than men. Participants overestimated their height by 0.44 cm ( p < .001, η2 = 0.075), but the interaction of sex and assessment method for height was not statistically significant. Underestimates of body mass correlated with marathon racing speed ( r = .24, p = .006) and body fat percentage ( r = −.29, p = .001) in men, but not in women ( p > .05). The disagreement between self-reported and measured anthropometric data in the present sample was lower than has been previously reported for the general population, suggesting that marathon runners may more accurately self-perceive and/or report their anthropometric characteristics. These findings are of practical value for health professionals and researchers (e.g., nutritionists and exercise physiologists) questionnaires to recreational marathon runners.

Dehydration and serum biochemical changes in marathon runners

1984 ◽  
Vol 52 (2) ◽  
pp. 183-187 ◽  
Author(s):  
P. H. Whiting ◽  
R. J. Maughan ◽  
J. D. B. Miller
Keyword(s):  
Biochemical Changes ◽  
Marathon Runners ◽  
Serum Biochemical

scholarly journals On the scattering of waves by nearly hard or soft incomplete vertical barriers in water of infinite depth

1998 ◽  
Vol 39 (3) ◽  
pp. 293-307
Author(s):  
P. F. Rhodes-Robinson
Keyword(s):  
Perturbation Theory ◽  
Infinite Depth ◽  
Hard Limit ◽  
Vertical Barriers ◽  
Progressive Waves ◽  
Porous Barriers

AbstractIn this paper the scattered progressive waves are determined due to progressive waves incident normally on certain types of partially immersed and completely submerged vertical porous barriers in water of infinite depth. The forms are approximate only, and are obtained using perturbation theory for nearly hard or soft barriers having high and low porosities respectively. The results for arbitrary porosity are difficult to obtain, in contrast to the well known hard limit of impermeable barriers.

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