Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1

Science ◽  
2019 ◽  
Vol 364 (6437) ◽  
pp. 283-285
Author(s):  
Meng He ◽  
Mira S. Chaurushiya ◽  
Joshua D. Webster ◽  
Sarah Kummerfeld ◽  
Rohit Reja ◽  
...  
Keyword(s):  
Intrinsic Apoptosis ◽  
Tumor Spectrum

The effects of intrinsic apoptosis on cystogenesis in PKD1-deficient ADPKD pig model

Gene ◽  
2021 ◽  
pp. 145792
Author(s):  
Runming Wang ◽  
Wenya Li ◽  
Suhong Zhang ◽  
Ya Song ◽  
Haiting Dai ◽  
...  
Keyword(s):  
Pig Model ◽  
Intrinsic Apoptosis

scholarly journals Poxviral Strategies to Overcome Host Cell Apoptosis

Pathogens ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 6
Author(s):  
Chathura D. Suraweera ◽  
Mark G. Hinds ◽  
Marc Kvansakul
Keyword(s):  
Viral Infections ◽  
B Cell Lymphoma ◽  
Intrinsic Apoptosis ◽  
Host Cell Apoptosis ◽  
Successful Infection ◽  
Infected Cells ◽  
Host Virus Interactions ◽  
Almost All ◽  
Virus Interactions ◽  
Multicellular Organisms

Apoptosis is a form of cellular suicide initiated either via extracellular (extrinsic apoptosis) or intracellular (intrinsic apoptosis) cues. This form of programmed cell death plays a crucial role in development and tissue homeostasis in multicellular organisms and its dysregulation is an underlying cause for many diseases. Intrinsic apoptosis is regulated by members of the evolutionarily conserved B-cell lymphoma-2 (Bcl-2) family, a family that consists of pro- and anti-apoptotic members. Bcl-2 genes have also been assimilated by numerous viruses including pox viruses, in particular the sub-family of chordopoxviridae, a group of viruses known to infect almost all vertebrates. The viral Bcl-2 proteins are virulence factors and aid the evasion of host immune defenses by mimicking the activity of their cellular counterparts. Viral Bcl-2 genes have proved essential for the survival of virus infected cells and structural studies have shown that though they often share very little sequence identity with their cellular counterparts, they have near-identical 3D structures. However, their mechanisms of action are varied. In this review, we examine the structural biology, molecular interactions, and detailed mechanism of action of poxvirus encoded apoptosis inhibitors and how they impact on host–virus interactions to ultimately enable successful infection and propagation of viral infections.

scholarly journals Apoptosis induced by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways

2013 ◽  
Vol 42 (4) ◽  
pp. 1349-1359 ◽  
Author(s):  
JINSHUN ZHAO ◽  
LINDA BOWMAN ◽  
RUTH MAGAYE ◽  
STEPHEN S. LEONARD ◽  
VINCENT CASTRANOVA ◽  
...  
Keyword(s):  
Tungsten Carbide ◽  
Cobalt Nanoparticles ◽  
Ros Generation ◽  
Intrinsic Apoptosis ◽  
Apoptosis Pathways ◽  
Jb6 Cells

scholarly journals Thrombospondin-1 Gene Expression Affects Survival and Tumor Spectrum of p53-Deficient Mice

2001 ◽  
Vol 159 (5) ◽  
pp. 1949-1956 ◽  
Author(s):  
Jack Lawler ◽  
Wei-Min Miao ◽  
Mark Duquette ◽  
Noël Bouck ◽  
Roderick T. Bronson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thrombospondin 1 ◽  
Tumor Spectrum ◽  
Deficient Mice
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