scholarly journals Parallel adaptation of rabbit populations to myxoma virus

Science ◽  
2019 ◽  
Vol 363 (6433) ◽  
pp. 1319-1326 ◽  
Author(s):  
Joel M. Alves ◽  
Miguel Carneiro ◽  
Jade Y. Cheng ◽  
Ana Lemos de Matos ◽  
Masmudur M. Rahman ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Parallel Evolution ◽  
Rapid Evolution ◽  
Antiviral Effect ◽  
Myxoma Virus ◽  
European Rabbit ◽  
The United Kingdom ◽  
Before And After ◽  
Evolution Of Resistance

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

Effectiveness of Low-Temperature Domestic Laundry on the Decontamination of Healthcare Workers' Uniforms

2011 ◽  
Vol 32 (11) ◽  
pp. 1103-1108 ◽  
Author(s):  
N. Lakdawala ◽  
J. Pham ◽  
M. Shah ◽  
J. Holton
Keyword(s):  
Low Temperature ◽  
Healthcare Workers ◽  
Bacterial Load ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Log Reduction ◽  
Healthcare Environment ◽  
The United Kingdom ◽  
Before And After

Objective.Most professionals in the healthcare environment wear uniforms. For the purpose of this study, we concentrated on nurses' uniforms. In the United Kingdom, many nurses are expected to launder their uniforms at home by using a domestic washing machine that frequently has low-temperature wash cycles. We have investigated whether the use of low-temperature wash cycles results in a microbiologically acceptable product to wear on the wards.Methods.We have assessed the bioburden on uniforms before and after laundry and the effectiveness of low-temperature wash cycles and ironing on removal of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. We did not assess the role of tumble drying.Results.We demonstrate contamination of uniforms by gram-negative bacteria after wash, the removal of MRSA at low-temperature wash cycles in the presence of detergent, and the eradication of gram-negative bacteria after ironing.Conclusions.Our conclusions are that laundry in a domestic situation at 60°C (140°F) for 10 minutes is sufficient to decontaminate hospital uniforms and reduces the bacterial load by more than 7-log reduction, that items left in the pockets are decontaminated to the same extent, that the addition of either a biological detergent or a nonbiological detergent is beneficial in removing MRSA from experimentally contaminated swatches, and that uniforms become recontaminated with low numbers of principally gram-negative bacteria after laundry but that these are effectively removed by ironing.

Do means-tested benefits alleviate poverty?: Evidence on Germany, Sweden and the United Kingdom from the Luxembourg Income Study

2000 ◽  
Vol 10 (1) ◽  
pp. 23-41 ◽  
Author(s):  
Christina Behrendt
Keyword(s):  
Low Income ◽  
Household Income ◽  
Poverty Alleviation ◽  
Western Europe ◽  
The United Kingdom ◽  
Before And After ◽  
Social Security Benefits ◽  
The Impact ◽  
The Relationship

This article analyses the relationship between means-tested benefits and poverty in Western Europe. Means-tested benefits, as social assistance or housing benefits, are designed as safeguards against poverty for the low-income strata of the population, but our knowledge on their impact is fairly limited. How effective are they in reducing poverty rates? To what degree can they fill the gap that income redistribution through taxes and non-means-tested social security benefits leaves? How large is the impact of means-tested transfers in private household budgets, and how does the role of means-tested benefits vary across countries? This article uses the household data of the Luxembourg Income Study to explore the effectiveness of means-tested programmes in terms of poverty alleviation in Britain, Germany and Sweden in the early 1990s. The results of this analysis show a considerable variation in the degree means-tested benefits can actually protect people from poverty. A comparison of household income before and after means-tested benefits exhibits different patterns of poverty alleviation. Using four relative poverty lines (30 percent, 40 percent, 50 percent and 60 percent of median household income adjusted for family size), this piece of research illustrates that there is considerable variation in the degree people are lifted up the income scale by means-tested benefits.

scholarly journals Second Earners and In-Work Poverty in Europe

2020 ◽  
pp. 1-23
Author(s):  
H. XAVIER JARA TAMAYO ◽  
DARIA POPOVA
Keyword(s):  
Household Income ◽  
Microsimulation Model ◽  
The European Union ◽  
The United Kingdom ◽  
Before And After ◽  
Part Time ◽  
The Impact ◽  
Low Pay ◽  
Net Replacement

Abstract Dual or multiple earnership has been considered an important factor to prevent in-work poverty. The aim of this paper is to quantify the impact of second earnership on the risk of in-work poverty and the role of the tax-benefit system in moderating this risk. Our analysis refers to 2014 and employs EUROMOD, the tax-benefit microsimulation model for the European Union and the United Kingdom. In order to assess the role of second earners in preventing in-work poverty we simulate a counterfactual scenario where second earners become unemployed. Our results show that the effect of net replacement rates (i.e. the ratio of household income before and after the transition of second earners to unemployment) on the probability of in-work poverty is negative and statistically significant, but in relative terms it appears to be small compared to the effects of individual labour market characteristics, such as low pay and part-time employment.

scholarly journals Genomic Analyses of New Genes and Their Phenotypic Effects Reveal Rapid Evolution of Essential Functions in Drosophila Development

2020 ◽  
Author(s):  
Shengqian Xia ◽  
Nicholas W. VanKuren ◽  
Chunyan Chen ◽  
Li Zhang ◽  
Clause Kemkemer ◽  
...  
Keyword(s):  
Genetic Basis ◽  
False Negative ◽  
Rapid Evolution ◽  
Phenotypic Effect ◽  
Gene Effects ◽  
New Genes ◽  
Developmental Effects ◽  
Genomic Analyses ◽  
Functional Analyses

ABSTRACTIt is a conventionally held dogma that the genetic basis underlying development is conserved in a long evolutionary time scale. Ample experiments based on mutational, biochemical, functional, and complementary knockdown/knockout approaches have revealed the unexpectedly important role of recently evolved new genes in the development of Drosophila. The recent progress in the analyses of gene effects and improvements in the computational identification of new genes, which has led to large sample sizes of new genes, open the door to investigate the evolution of gene essentiality with a phylogenetically high resolution. These advancements also raised interesting issues related to phenotypic effect analyses of genes, particularly of those that recently originated. Here we reported our analyses of these issues, including the dating of gene ages, the interpretation of RNAi data that may confuse false positive/false negative rates, and the potential confounding impact of compensation and developmental effects that were not considered during previous CRISPR knockout experiments. We further analyzed new data from knockdowns of 702 new genes (~66% of total 1,070 Drosophila melanogaster new genes), revealing a similarly high proportion of essential genes from recent evolution, compared to those found in distant ancestors of D. melanogaster. Knockout of a few young genes detected analogous essentiality. Furthermore, our experimentally determined distribution and comparison of knockdown efficiency in different RNAi libraries provided valuable data for general functional analyses of genes. Taken together, these data, along with an improved understanding of the phenotypic effect analyses of new genes, provide further evidence to the conclusion that new genes in Drosophila quickly evolved essential functions in viability during development.

Child and Adolescent Suicides in Bosnia and Herzegovina Before and After the War (1992–1995)

Crisis ◽  
2010 ◽  
Vol 31 (3) ◽  
pp. 160-164 ◽  
Author(s):  
Almir Fajkic ◽  
Orhan Lepara ◽  
Martin Voracek ◽  
Nestor D. Kapusta ◽  
Thomas Niederkrotenthaler ◽  
...  
Keyword(s):  
Bosnia And Herzegovina ◽  
Age Differences ◽  
Suicide Risk ◽  
Child And Adolescent ◽  
Youth Suicide ◽  
Southeastern Europe ◽  
Suicide Rates ◽  
Before And After ◽  
Sex And Age Differences

Background: Evidence on youth suicides from Southeastern Europe is scarce. We are not aware of previous reports from Bosnia and Herzegovina, which experienced war from 1992 to 1995. Durkheim’s theory of suicide predicts decreased suicide rates in wartime and increased rates afterward. Aims: To compare child and adolescent suicides in Bosnia and Herzegovina before and after the war. Methods: Data on youth suicide for prewar (1986–90) and postwar (2002–06) periods were analyzed with respect to prevalence, sex and age differences, and suicide methods. Suicide data from 1991 through 2001 were not available. Results: Overall youth suicide rates were one-third lower in the postwar than in the prewar period. This effect was most pronounced for girls, whose postwar suicide rates almost halved, and for 15–19-year-old boys, whose rates decreased by about a one-fourth. Suicides increased among boys aged 14 or younger. Firearm suicides almost doubled proportionally and were the predominant postwar method, while the most common prewar method had been hanging. Conclusions: The findings from this study indicate the need for public education in Bosnia and Herzegovina on the role of firearm accessibility in youth suicide and for instructions on safe storage in households. Moreover, raising societal awareness about suicide risk factors and suicide prevention is needed.

Anti-Myelin Oligodendrocyte Glycoprotein Encephalomyelitis and Extensive Longitudinal Transverse Myelitis Associated with Compound Heterozygous NLRP3 Missense Mutations in a Young Child

2020 ◽  
Author(s):  
Deirdre O'Sullivan ◽  
Michael Moore ◽  
Susan Byrne ◽  
Andreas O. Reiff ◽  
Susanna Felsenstein
Keyword(s):  
Young Child ◽  
Genetic Basis ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Compound Heterozygous ◽  
Missense Mutations ◽  
Childhood Onset

AbstractAcute disseminated encephalomyelitis in association with extensive longitudinal transverse myelitis is reported in a young child with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody with heterozygous NLRP3 missense mutations; p.(Arg488Lys) and p.(Ser159Ile). This case may well present an exceptional coincidence, but may describe a yet unrecognized feature of the spectrum of childhood onset cryopyrinopathies that contribute to the understanding of the genetic basis for anti-MOG antibody positive encephalomyelitis. Based on this observation, a larger scale study investigating the role of NLRP3 and other inflammasomes in this entity would provide important pathophysiological insights and potentially novel avenues for treatment.

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

2018 ◽  
Vol 15 (1) ◽  
pp. 55-72
Author(s):  
Herlin Hamimi ◽  
Abdul Ghafar Ismail ◽  
Muhammad Hasbi Zaenal
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Wealth Distribution ◽  
Absolute Poverty ◽  
Before And After ◽  
The Status ◽  
Being There ◽  
The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

The role of demographic variables as the moderator between organizational variables and job stress among teachers in Sabah

2009 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Najihah Hanisah Marmaya ◽  
Syed Azizi Wafa
Keyword(s):  
United Kingdom ◽  
Sample Size ◽  
Job Stress ◽  
Demographic Variables ◽  
Personal Factors ◽  
Occupational Groups ◽  
Organizational Variables ◽  
Population Norms ◽  
The United Kingdom

A nationwide investigation into stress among teachers in the United Kingdom, found teachers to be reporting stress-related problems which were far higher than those of the population norms and other comparable occupational groups. Job stress can be influenced by personal factors (Matteson & Ivancevich, 1999). The present study examined the role of demographic variables as the moderator between organizational variables and job stress. A sample size of 177 teachers participated in this study revealed that teachers in Tawau and Lahad Datu experienced low stress levels. This study found that demographic variables do not serve as the moderator between organizational variables and job stress.

Sign in / Sign up

Export Citation Format

Share Document