scholarly journals Resistance to malaria through structural variation of red blood cell invasion receptors

Science ◽  
2017 ◽  
Vol 356 (6343) ◽  
pp. eaam6393 ◽  
Author(s):  
Ellen M. Leffler ◽  
Gavin Band ◽  
George B. J. Busby ◽  
Katja Kivinen ◽  
Quang Si Le ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Structural Variation

scholarly journals Resistance to malaria through structural variation of red blood cell invasion receptors

2016 ◽  
Author(s):  
Ellen M. Leffler ◽  
Gavin Band ◽  
George B.J. Busby ◽  
Katja Kivinen ◽  
Quang Si Le ◽  
...  
Keyword(s):  
Blood Cell ◽  
Severe Malaria ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Structural Variation ◽  
Sub Saharan Africa ◽  
Natural Resistance ◽  
Cell Phenotype ◽  
Human Populations ◽  
Structural Variant

AbstractPlasmodium falciparuminvades human red blood cells by a series of interactions between host and parasite surface proteins. Here we analyse whole genome sequence data from worldwide human populations, including 765 new genomes from across sub-Saharan Africa, and identify a diverse array of large copy number variants affecting the host invasion receptor genesGYPAandGYPB. We find that a nearby reported association with severe malaria is explained by a complex structural variant that involves the loss ofGYPBand gain of two hybrid genes, each with a GYPB extracellular domain and GYPA intracellular domain. This variant reduces the risk of severe malaria by 40% and has recently risen in frequency in parts of Kenya. We show that the structural variant encodes the Dantu blood group antigen, and therefore a serologically distinct red cell phenotype. These findings demonstrate that structural variation of red blood cell invasion receptors is associated with natural resistance toP. falciparummalaria.

The RhopH complex is transferred to the host cell cytoplasm following red blood cell invasion by Plasmodium falciparum

2008 ◽  
Vol 160 (2) ◽  
pp. 81-89 ◽  
Author(s):  
Laetitia Vincensini ◽  
Gamou Fall ◽  
Laurence Berry ◽  
Thierry Blisnick ◽  
Catherine Braun Breton
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Host Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Cell Cytoplasm ◽  
Host Cell Cytoplasm

The role of malaria merozoite proteases in red blood cell invasion

2005 ◽  
Vol 8 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Rebecca A O’Donnell ◽  
Michael J Blackman
Keyword(s):  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell

scholarly journals A multifunctional serine protease primes the malaria parasite for red blood cell invasion

2009 ◽  
Vol 28 (6) ◽  
pp. 725-735 ◽  
Author(s):  
Konstantinos Koussis ◽  
Chrislaine Withers-Martinez ◽  
Sharon Yeoh ◽  
Matthew Child ◽  
Fiona Hackett ◽  
...  
Keyword(s):  
Blood Cell ◽  
Serine Protease ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Malaria Parasite

scholarly journals Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor

2017 ◽  
Vol 21 (6) ◽  
pp. 731-741.e10 ◽  
Author(s):  
Joana Mendonca Santos ◽  
Gabrielle Josling ◽  
Philipp Ross ◽  
Preeti Joshi ◽  
Lindsey Orchard ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Malaria Parasite

Peptide derivatives specific for a Plasmodium falciparum protease involved in red blood cell invasion by merozoites

Peptides ◽  
1988 ◽  
pp. 662-663
Author(s):  
Roger Mayer ◽  
Isabelle Picard ◽  
François Bernard ◽  
Philippe Lawton ◽  
Philippe Grellier ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Peptide Derivatives

Malaria proteases and red blood cell invasion

1993 ◽  
Vol 9 (3) ◽  
pp. 92-96 ◽  
Author(s):  
C. Braun Breton ◽  
L.H. Pereira da Silva
Keyword(s):  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell

scholarly journals Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

2016 ◽  
Vol 40 (3) ◽  
pp. 343-372 ◽  
Author(s):  
James G. Beeson ◽  
Damien R. Drew ◽  
Michelle J. Boyle ◽  
Gaoqian Feng ◽  
Freya J.I. Fowkes ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Surface Proteins
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