Electrical turbulence in three-dimensional heart muscle

Science ◽  
1994 ◽  
Vol 266 (5187) ◽  
pp. 1003-1006 ◽  
Author(s):  
A. Winfree
Keyword(s):  
Heart Muscle ◽  
Three Dimensional

Vortices in Motionless Media

1990 ◽  
Vol 43 (12) ◽  
pp. 297-309 ◽  
Author(s):  
A. T. Winfree
Keyword(s):  
Mathematical Models ◽  
Chemical Reactions ◽  
Heart Muscle ◽  
Local Reaction ◽  
Three Dimensional ◽  
Vortex Filament ◽  
Local Geometry ◽  
Lateral Motion ◽  
Local Activation ◽  
Vortex Lines

Three-dimensional continua capable of recurrent local activation are observed—both in the laboratory and in mathematical models—to support persistent self-organizing patterns of activity most conveniently described in terms of vortex lines. These lines generally close in rings, which may be linked and knotted. In some cases they adopt stable configurations resembling tiny dynamos of millimeter dimensions. The dynamics of these “organizing centers” has been investigated in certain chemical reactions, in heart muscle, and numerically in digital computers. The pertinent mathematical principles appear to entail consequences of local reaction and neighborhood diffusion, in the form of a dependency of the vortex filament’s lateral motion upon its local geometry and, when too closely approached by another segment of vortex filament, upon the distance and orientation involved.

Three‐dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system

1997 ◽  
Vol 11 (8) ◽  
pp. 683-694 ◽  
Author(s):  
Thomas Eschenhagen ◽  
Christine Fink ◽  
Ute Remmers ◽  
Hasso Scholz ◽  
Jens Wattchow ◽  
...  
Keyword(s):  
Heart Muscle ◽  
Three Dimensional ◽  
Collagen Matrix ◽  
Model System ◽  
Muscle Model ◽  
Embryonic Cardiomyocytes

Establishing the Framework to Support Bioartificial Heart Fabrication Using Fibrin-Based Three-Dimensional Artificial Heart Muscle

2014 ◽  
Vol 39 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Matthew Hogan ◽  
Mohamed Mohamed ◽  
Ze-Wei Tao ◽  
Laura Gutierrez ◽  
Ravi Birla
Keyword(s):  
Heart Muscle ◽  
Artificial Heart ◽  
Three Dimensional
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