Effects of the obese gene product on body weight regulation in ob/ob mice

Science ◽  
1995 ◽  
Vol 269 (5223) ◽  
pp. 540-543 ◽  
Author(s):  
M. Pelleymounter ◽  
M. Cullen ◽  
M. Baker ◽  
R Hecht ◽  
D Winters ◽  
...  
Keyword(s):  
Body Weight ◽  
Gene Product ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Obese Gene

Cholecystokinin and leptin act synergistically to reduce body weight

2000 ◽  
Vol 278 (4) ◽  
pp. R882-R890 ◽  
Author(s):  
Claire A. Matson ◽  
Dana F. Reid ◽  
Todd A. Cannon ◽  
Robert C. Ritter
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Body Weight Loss ◽  
Central Action ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Obese Gene ◽  
Reduce Body Weight ◽  
Rats And Mice ◽  
Peripheral Action

Leptin, the product of the obese gene, reduces food intake and body weight in rats and mice, whereas administration of the gut-peptide CCK reduces meal size but not body weight. In the current experiments, we report that repeated daily combination of intracerebroventricular leptin and intraperitoneal CCK results in significantly greater loss of body weight than does leptin alone. However, leptin plus CCK treatment does not synergistically reduce the size of individual 30-min sucrose meals during this period, and the effect of leptin-CCK combination on daily chow intake, while significant, is small compared with the robust effects on body weight loss. This synergistic effect on body weight loss depends on a peripheral action of CCK and a central action of leptin. These data suggest a previously unsuspected role for CCK in body weight regulation that may not depend entirely on reduction of feeding behavior and suggest a strategy for enhancing the effects of leptin in leptin-resistant obese individuals.

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

2018 ◽  
Author(s):  
Hsu JY ◽  
Crawley S ◽  
Chen M ◽  
Ayupova DA ◽  
Lindhout DA ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Regulation ◽  
Body Weight Regulation

Feeding and body weight regulation after 6-OHDA application into the preoptic area

1991 ◽  
Vol 27 (3-4) ◽  
pp. 359-365 ◽  
Author(s):  
L. Lénárd ◽  
Z. Karádi ◽  
G. Jandó ◽  
H. Yoshimatsu ◽  
A. Hajnal ◽  
...  
Keyword(s):  
Body Weight ◽  
Preoptic Area ◽  
Weight Regulation ◽  
Body Weight Regulation

scholarly journals Nutrigenomics of Body Weight Regulation: A Rationale for Careful Dissection of Individual Contributors

Nutrients ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 4531-4551 ◽  
Author(s):  
Jaap Keijer ◽  
Femke Hoevenaars ◽  
Arie Nieuwenhuizen ◽  
Evert van Schothorst
Keyword(s):  
Body Weight ◽  
Weight Regulation ◽  
Body Weight Regulation
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