Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model

Science ◽  
1994 ◽  
Vol 266 (5182) ◽  
pp. 107-109 ◽  
Author(s):  
S. Gabriel ◽  
K. Brigman ◽  
B. Koller ◽  
R. Boucher ◽  
M. Stutts
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cholera Toxin ◽  
Cystic Fibrosis Mouse

CYSTIC FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA TOXIN IN THE CYSTIC FIBROSIS MOUSE MODEL

PEDIATRICS ◽  
1995 ◽  
Vol 96 (2) ◽  
pp. 411-411
Author(s):  
David H. Dreyfus ◽  
Andrew H. Liu
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cholera Toxin ◽  
Secretory Diarrhea ◽  
Homozygous State ◽  
Widespread Distribution ◽  
Cystic Fibrosis Mouse ◽  
Cftr Mutations

The authors propose that the widespread distribution of cystic fibrosis may reflect an underlying benefit to heterozygous individuals for CFTR mutations via increased resistance to secretory diarrhea. Ironically, in the homozygous state, CFTR disfunction leads to increased infection with a variety of respiratory and other pathogens, thus negating any benefit to human homozygotes.

scholarly journals Poly-l-aspartic Acid Enhances and Prolongs Gentamicin-mediated Suppression of theCFTR-G542X Mutation in a Cystic Fibrosis Mouse Model

2009 ◽  
Vol 284 (11) ◽  
pp. 6885-6892 ◽  
Author(s):  
Ming Du ◽  
Kim M. Keeling ◽  
Liming Fan ◽  
Xiaoli Liu ◽  
David M. Bedwell
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Aspartic Acid ◽  
Cystic Fibrosis Mouse

scholarly journals WS15.2 The secreted mucus proteome in ileum of a cystic fibrosis mouse model

2014 ◽  
Vol 13 ◽  
pp. S31
Author(s):  
A.M. Rodríguez-Piñeiro ◽  
A. Ermund ◽  
A. Schütte ◽  
G.C. Hansson
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cystic Fibrosis Mouse

scholarly journals Cystic fibrosis mouse model-dependent intestinal structure and gut microbiome

2015 ◽  
Vol 26 (5-6) ◽  
pp. 222-234 ◽  
Author(s):  
Mark Bazett ◽  
Lisa Honeyman ◽  
Anguel N. Stefanov ◽  
Christopher E. Pope ◽  
Lucas R. Hoffman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Gut Microbiome ◽  
Cystic Fibrosis Mouse

WS07.4 Development of a humanised cystic fibrosis mouse model

2021 ◽  
Vol 20 ◽  
pp. S14
Author(s):  
A. Mottais ◽  
C. Detry ◽  
M. Beka ◽  
Y. Achouri ◽  
T. Leal
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cystic Fibrosis Mouse

Generation and characterization of a ΔF508 cystic fibrosis mouse model

1995 ◽  
Vol 10 (4) ◽  
pp. 445-452 ◽  
Author(s):  
William H. Colledge ◽  
Benjamin S. Abella ◽  
Kevin W. Southern ◽  
Rosemary Ratcliff ◽  
Canwen Jiang ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cystic Fibrosis Mouse

scholarly journals WS13-4 Development of a humanised cystic fibrosis mouse model

2019 ◽  
Vol 18 ◽  
pp. S25
Author(s):  
A. Mottais ◽  
Y. Achouri ◽  
M. Delion ◽  
M. Beka ◽  
A. Reynaerts ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Cystic Fibrosis Mouse

scholarly journals A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0199573 ◽  
Author(s):  
Daniel R. McHugh ◽  
Miarasa S. Steele ◽  
Dana M. Valerio ◽  
Alexander Miron ◽  
Rachel J. Mann ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Model ◽  
Nonsense Mutation ◽  
Cystic Fibrosis Mouse
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