Human myeloma cell line carrying a Philadelphia chromosome

Science ◽  
1982 ◽  
Vol 216 (4549) ◽  
pp. 997-999 ◽  
Author(s):  
A Karpas ◽  
P Fischer ◽  
D Swirsky
Keyword(s):  
Cell Line ◽  
Philadelphia Chromosome ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

scholarly journals Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182152 ◽  
Author(s):  
Etsuko Tokunaga ◽  
Hidehiko Akiyama ◽  
Vadim A. Soloshonok ◽  
Yuki Inoue ◽  
Hideaki Hara ◽  
...  
Keyword(s):  
Cell Line ◽  
Myeloma Cell ◽  
Biological Evaluation ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

Abstract 400: Establishment and characterization of a novel IL6-dependent HLA-A2+ human myeloma cell line LNT1

2010 ◽  
Author(s):  
Sun-Young Kong ◽  
Weihua Song ◽  
Xian-Feng Li ◽  
Sabikun Nahar ◽  
Paola Dal Cin ◽  
...  
Keyword(s):  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

Purification and characterization of IgE produced by human myeloma cell line, U266

1986 ◽  
Vol 23 (2) ◽  
pp. 159-167 ◽  
Author(s):  
Ikeyama Shuichi ◽  
Nakagawa Shizue ◽  
Arakawa Mutsushi ◽  
Sugino Hiromu ◽  
Kakinuma Atsushi
Keyword(s):  
Cell Line ◽  
Myeloma Cell ◽  
Purification And Characterization ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

scholarly journals Human Myeloma Cell Line (KHM-4) Established from A Patient with Multiple Myeloma Associated with Hyperammonemia.

1992 ◽  
Vol 31 (3) ◽  
pp. 339-343 ◽  
Author(s):  
Hiromitsu MATSUZAKI ◽  
Fumihiko MATSUNO ◽  
Minoru YOSHIDA ◽  
Hiroyuki HATA ◽  
Koushiro OKAZAKI ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

scholarly journals Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266

Blood ◽  
1991 ◽  
Vol 77 (3) ◽  
pp. 587-593 ◽  
Author(s):  
G Schwab ◽  
CB Siegall ◽  
LA Aarden ◽  
LM Neckers ◽  
RP Nordan
Keyword(s):  
Cell Line ◽  
Interleukin 6 ◽  
Polymerase Chain Reaction Amplification ◽  
Myeloma Cell ◽  
Conclusive Evidence ◽  
Parameter Analysis ◽  
Autocrine Growth ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell

It has been reported recently that freshly isolated human myeloma cell cultures proliferate in response to added interleukin-6 (IL-6). Endogenous levels of IL-6 found in the same cultures suggested that an autocrine growth loop may contribute to cell growth. However, the lack of homogenous cell populations in primary myeloma cultures has made it difficult to distinguish between paracrine and autocrine growth mechanisms. To precisely address the autocrine growth issue we have evaluated the growth of the human myeloma cell line, U266. We have found that a neutralizing anti-IL-6 monoclonal antibody can inhibit U266 proliferation. Furthermore, the addition of IL-6 antisense oligonucleotides also inhibits U266 proliferation. These effects are reversed by adding IL-6, suggesting the presence of an autocrine loop. Using bioassays with two different IL-6-dependent cell lines, we were able to detect IL-6 in concentrated U266 supernatants. IL-6 mRNA was detected by polymerase chain reaction amplification of cDNA. Cell cycle parameter analysis shows that IL-6 acts to release a block in G1. Taken together these results present conclusive evidence for IL-6-mediated autocrine growth in the U266 human myeloma cell line.

Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax

Life Sciences ◽  
2013 ◽  
Vol 92 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Meng Zhang ◽  
Li-Ping Liu ◽  
Yuling Chen ◽  
Xiao-ying Tian ◽  
Jian Qin ◽  
...  
Keyword(s):  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Rpmi 8226 ◽  
Human Myeloma Cell

scholarly journals Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro

2019 ◽  
Vol 71 (2) ◽  
pp. 573-581 ◽  
Author(s):  
Akira Iwamoto ◽  
Yuichi Inoue ◽  
Hirofumi Tachibana ◽  
Hiroharu Kawahara
Keyword(s):  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Human Myeloma Cell Line ◽  
Human Myeloma Cell
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