Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies

Science ◽  
1983 ◽  
Vol 222 (4623) ◽  
pp. 512-515 ◽  
Author(s):  
D. Vallera ◽  
R. Ash ◽  
E. Zanjani ◽  
J. Kersey ◽  
T. LeBien ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Monoclonal Antibodies ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Marrow Transplantation ◽  
Human Bone ◽  
Human Bone Marrow

Gene Markers in Human Bone Marrow Transplantation

Vox Sanguinis ◽  
1977 ◽  
Vol 33 (4) ◽  
pp. 202-205 ◽  
Author(s):  
Maryellen C. Sparkes ◽  
Michol L. Crist ◽  
Robert S. Sparkes ◽  
Robert P. Gale ◽  
Stephen A. Feig ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Gene Markers

scholarly journals Analysis of T lymphocytes after bone marrow transplantation using monoclonal antibodies

Blood ◽  
1982 ◽  
Vol 60 (3) ◽  
pp. 578-582 ◽  
Author(s):  
R Fox ◽  
R McMillan ◽  
W Spruce ◽  
P Tani ◽  
D Mason
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Monoclonal Antibodies ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Cell Surface ◽  
Marrow Transplantation ◽  
T Cell Subsets ◽  
Clinically Significant ◽  
Abnormal Ratio

Abstract Using monoclonal antibodies to cell surface antigens and fluorescent cell sorter analysis, we studied peripheral blood lymphocyte subsets after bone marrow transplantation (BMT). In 13 patients studied 3 mo or more after BMT, the ratio of T-cell subsets defined by antibodies OKT4 and OKT8 was reversed (OKT4/OK%8 = 0.7 +/- 0.3) in comparison to normal volunteers or bone marrow donors (ratio OKT4/OKT8 = 1.7 +/- 0.4) (p less than 0.001). This reversed ratio persisted for up to 3 yr after BMT. In contrast to a previous report, presence of an abnormal ratio of T-cell subsets did not correlate with clinically significant graft- versus-host disease (GVHD). In agreement with a previous study, (26% +/- 8%; less than 4% in normals (p less than 0.001) and antibody OKT10 reactive cells (39% +/- 20% versus 10% +/- 4%) (p less than 0.01), suggesting in vivo activation. However, their PBL did not react with antibody B3/25 (antitransferrin receptor), a marker found on normal PBL after in vitro activation by mitogens (BMT patients less than 5%; normal PBL T cells plus PHA 45% +/- 11%). These results demonstrate that BMT patients have: (A) an abnormal ratio of T-cell subsets in the presence or absence of clinically significant GVDH disease so that these measurements were not useful in monitoring patients; (B) an increased number of T cells with cell surface phenotype (OKT8+, Ia+, OKT10+, B3/25-) that is distinct from normals but similar to patients with infectious mononucleosis or acquired hypogammaglobulinemia.

ENDOGENOUS INTERLEUKIN 1 RECEPTOR ANTAGONIST DURING HUMAN BONE MARROW TRANSPLANTATION

1997 ◽  
Vol 63 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Hubert Schwaighofer ◽  
Georg Oberhuber ◽  
Holger Hebart ◽  
Hermann Einsele ◽  
Manfred Herold ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Receptor Antagonist ◽  
Marrow Transplantation ◽  
Interleukin 1 ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Colonic complications following human bone marrow transplantation

2015 ◽  
Vol 35 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Paulino Martínez Hernández-Magro ◽  
Juan Pablo Peña Ruiz Esparza ◽  
Eduardo Villanueva Sáenz ◽  
José Luis Rocha Ramírez ◽  
Enrique Gómez Morales ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Human Bone ◽  
Human Bone Marrow
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