Latent form of Scrapie virus: a new factor in slow-virus disease

Science ◽  
1977 ◽  
Vol 196 (4290) ◽  
pp. 668-671 ◽  
Author(s):  
J Hotchin ◽  
R Buckley
Keyword(s):  
Virus Disease ◽  
Latent Form ◽  
Slow Virus ◽  
Slow Virus Disease

scholarly journals THE PATHOGENESIS OF ALEUTIAN DISEASE OF MINK

1969 ◽  
Vol 130 (3) ◽  
pp. 575-593 ◽  
Author(s):  
David D. Porter ◽  
Austin E. Larsen ◽  
Helen G. Porter
Keyword(s):  
Disease Virus ◽  
Viral Antigen ◽  
Virus Disease ◽  
Virus Antigen ◽  
Slow Virus Disease ◽  
Infected Liver ◽  
Aleutian Disease Of Mink ◽  
Spleen And Lymph Nodes ◽  
High Virus ◽  
Aleutian Disease Virus

Mink inoculated with 1 x 105 ID50 of Aleutian disease virus revealed very high virus titers in the tissues 8–18 days later. The highest virus titers observed were 5 x 108 ID50 per g of spleen and 1 x 109 ID50 per g of liver 10 days after inoculation. Concomitant with the increase in infectious virus titers, viral antigen(s) was found in the cytoplasm of macrophages in the spleen and lymph nodes and in Kupffer cells in the liver. Antiviral antibody was assayed by indirect immunofluorescence, using sections of infected liver as the source of antigen. A few mink infected for 9 days and all those infected 10 days or more developed antibody to Aleutian disease virus antigen(s). By 60 days after infection, when hypergammaglobulinemia was marked, the mink had an exceptionally high mean antibody titer of 100,000. The pathogenesis of the glomerulonephritis of Aleutian disease is apparently related to formation of viral antigen-antibody-complement complexes which lodge in glomerular capillaries. No evidence was found that viral infection of the kidney took place, and no autoimmune responses were found. In this "slow-virus" disease the virus replicates rapidly and the morphologic and biochemical manifestations of disease are apparently due to the continuing interplay between a replicating antigen and the host immune response.

Indikationen für chinesische Arzneimitteltherapie bei Covid-19-Erkrankungen

2020 ◽  
Vol 12 (03) ◽  
pp. 18-18
Author(s):  
Christian Thede
Keyword(s):  
Virus Disease ◽  
Traditionelle Chinesische Medizin ◽  
Chinesische Medizin ◽  
Corona Virus ◽  
Chinesische Arzneimitteltherapie

SummaryIn Reaktion auf den massiven Ausbruch von Covid-19-Erkrankungen in der Region Wuhan wurde von staatlicher Seite bereits Ende Januar 2020 eine Expertenkommission namhafter chinesischer TCM-Fachleute berufen. Nach der Sichtung einer größeren Anzahl von Patienten in Wuhan wurdenTherapieprotokolle für verschiedene Krankheitsstadien formuliert, die in den „Guidance for Corona Virus Disease 2019“ des Generalbüros der Nationalen Hygiene und Gesundheitskommission und des Büros der staatlichen Verwaltung für traditionelle chinesische Medizin aufgenommen wurden.

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