Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

Science ◽  
1986 ◽  
Vol 231 (4742) ◽  
pp. 1123-1128 ◽  
Author(s):  
E. Howell ◽  
J. Villafranca ◽  
M. Warren ◽  
S. Oatley ◽  
J Kraut
Keyword(s):  
Aspartic Acid ◽  
Dihydrofolate Reductase ◽  
Functional Role

Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase

Biochemistry ◽  
1990 ◽  
Vol 29 (27) ◽  
pp. 6428-6436 ◽  
Author(s):  
Jiu Tsair Tsay ◽  
James R. Appleman ◽  
William A. Beard ◽  
Neal J. Prendergast ◽  
Tavner J. Delcamp ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Kinetic Investigation ◽  
Human Dihydrofolate Reductase

Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

Biochemistry ◽  
1991 ◽  
Vol 30 (46) ◽  
pp. 11092-11103 ◽  
Author(s):  
Mark S. Warren ◽  
Katherine A. Brown ◽  
Martin F. Farnum ◽  
Elizabeth E. Howell ◽  
Joseph Kraut
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

scholarly journals Functional role of a conserved aspartic acid residue in the motor of the Na+-driven flagellum from Vibrio cholerae

2009 ◽  
Vol 1787 (10) ◽  
pp. 1198-1204 ◽  
Author(s):  
Thomas Vorburger ◽  
Andreas Stein ◽  
Urs Ziegler ◽  
Georg Kaim ◽  
Julia Steuber
Keyword(s):  
Vibrio Cholerae ◽  
Aspartic Acid ◽  
Functional Role ◽  
Aspartic Acid Residue

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis

Biochemistry ◽  
1987 ◽  
Vol 26 (13) ◽  
pp. 4093-4100 ◽  
Author(s):  
Jin Tann Chen ◽  
Kazunari Taira ◽  
Chen Pei D. Tu ◽  
Stephen J. Benkovic
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization

Biochemistry ◽  
1992 ◽  
Vol 31 (34) ◽  
pp. 7826-7833 ◽  
Author(s):  
Luyuan Li ◽  
Peter E. Wright ◽  
Stephen J. Benkovic ◽  
Christopher J. Falzone
Keyword(s):  
Escherichia Coli ◽  
Transition State ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Transition State Stabilization

Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase

1997 ◽  
Vol 119 (35) ◽  
pp. 8166-8176 ◽  
Author(s):  
Vladimir A. Karginov ◽  
Sergey V. Mamaev ◽  
Haoyun An ◽  
Mark D. Van Cleve ◽  
Sidney M. Hecht ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Dihydrofolate Reductase ◽  
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