Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone

Science ◽  
1977 ◽  
Vol 197 (4299) ◽  
pp. 183-186 ◽  
Author(s):  
Y Hosobuchi ◽  
J. Adams ◽  
R Linchitz
Keyword(s):  
Electrical Stimulation ◽  
Pain Relief ◽  
Gray Matter ◽  
Central Gray Matter ◽  
Central Gray ◽  
Stimulation Of

Inhibition of jaw opening reflexes by stimulation of the central gray matter and raphe nuclei in cats

1985 ◽  
Vol 16 (3) ◽  
pp. 297-305
Author(s):  
E. V. Gura ◽  
V. A. Yakhnitsa ◽  
Yu. P. Limanskii
Keyword(s):  
Gray Matter ◽  
Raphe Nuclei ◽  
Central Gray Matter ◽  
Jaw Opening ◽  
Central Gray ◽  
Raphé Nuclei ◽  
Stimulation Of

Pressor responses and adrenomedullary catecholamine release during brain stimulation in the rat

1981 ◽  
Vol 59 (5) ◽  
pp. 485-492 ◽  
Author(s):  
Pierre Gauthier
Keyword(s):  
Blood Pressure ◽  
Electrical Stimulation ◽  
Brain Stimulation ◽  
Active Sites ◽  
Pressor Response ◽  
Secondary Phase ◽  
Plasma Catecholamine ◽  
Central Gray Matter ◽  
Central Gray ◽  
Stimulation Of

Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus, in the region of the parafascicularis nucleus, and in the central gray matter and the tegmentum of the mesencephalon. Together with the biphasic pressor response brain stimulation also increased plasma catecholamine (CA) concentrations 10-fold. Either bilateral adrenalectomy or demedullation selectively abolished the secondary phase of the pressor response and greatly reduced the plasma CA response to stimulation. After chemical destruction of the terminals of the sympathetic neurones by intravenous administration of 6-hydroxydopamine (6-OHDA), the primary pressor phase was eliminated whereas the secondary phase as well as plasma CA concentration reached higher levels than in normal rats. 6-OHDA treatment combined with adrenalectomy completely abolished both pressor and CA responses. The results demonstrate that adrenomedullary mechanisms capable of increasing blood pressure significantly can be activiated by electrical stimulation of different sites in the diencephalon and mesencephalon.

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