A persistent untranslated sequence within bacteriophage T4 DNA topoisomerase gene 60

Science ◽  
1988 ◽  
Vol 239 (4843) ◽  
pp. 1005-1012 ◽  
Author(s):  
W. Huang ◽  
S. Ao ◽  
S Casjens ◽  
R Orlandi ◽  
R Zeikus ◽  
...  
Keyword(s):  
Bacteriophage T4 ◽  
Dna Topoisomerase ◽  
Untranslated Sequence

Upstream stimulators for recoding

1995 ◽  
Vol 73 (11-12) ◽  
pp. 1123-1129 ◽  
Author(s):  
B. Larsen ◽  
K. Brady ◽  
J. F. Atkins ◽  
J. Peden ◽  
S. Matsufuji ◽  
...  
Keyword(s):  
Bacteriophage T4 ◽  
Gene Encoding ◽  
Dna Topoisomerase ◽  
E Coli ◽  
Optimal Spacing ◽  
A Subunit ◽  
Shine Dalgarno Sequence ◽  
Acid Domain ◽  
Frameshift Event ◽  
Amino Acid Domain

Recent progress in elucidation of 5′ stimulatory elements for translational recoding is reviewed. A 5′ Shine–Dalgarno sequence increases both +1 and −1 frameshift efficiency in several genes; examples cited include the E. coli prfB gene encoding release factor 2 and the dnaX gene encoding the γ and τ subunits of DNA polymerase III holoenzyme. The spacing between the Shine–Dalgarno sequence and the shift site is critical in both the +1 and −1 frameshift cassettes; however, the optimal spacing is quite different in the two cases. A frameshift in a mammalian chromosomal gene, ornithine decarboxylase antizyme, has recently been reported; 5′ sequences have been shown to be vital for this frameshift event. Escherichia coli bacteriophage T4 gene 60 encodes a subunit of its type II DNA topoisomerase. The mature gene 60 mRNA contains an internal 50 nucleotide region that appears to be bypassed during translation. A 16 amino acid domain of the nascent peptide is necessary for this bypass to occur.Key words: recoding, frameshifting, peptide factor, stimulatory elements.

scholarly journals Common Sites for Recombination and Cleavage Mediated by Bacteriophage T4 DNA Topoisomerase in vitro

1989 ◽  
Vol 264 (22) ◽  
pp. 12785-12790
Author(s):  
M Chiba ◽  
H Shimizu ◽  
A Fujimoto ◽  
H Nashimoto ◽  
H Ikeda
Keyword(s):  
Bacteriophage T4 ◽  
Dna Topoisomerase

Role of recombinational repair in sensitivity to an antitumour agent that inhibits bacteriophage T4 type II DNA topoisomerase

1996 ◽  
Vol 20 (6) ◽  
pp. 1145-1154 ◽  
Author(s):  
Sue H. Neece ◽  
Kelly Carles-Kinch ◽  
Daniel J. Tomso ◽  
Kenneth N. Kreuzer
Keyword(s):  
Bacteriophage T4 ◽  
Recombinational Repair ◽  
Type Ii ◽  
Dna Topoisomerase ◽  
Antitumour Agent
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