Boundary Formation in Drosophila Wing: Notch Activity Attenuated by the POU Protein Nubbin

1998 ◽  
Vol 281 (5375) ◽  
pp. 409-413 ◽  
Author(s):  
C. J. Neumann
Keyword(s):  
Boundary Formation ◽  
Notch Activity ◽  
Drosophila Wing

scholarly journals Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin.

Genetics ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 353-363 ◽  
Author(s):  
J Jack ◽  
Y DeLotto
Keyword(s):  
Sense Organ ◽  
Epidermal Cells ◽  
Additive Effect ◽  
Mutant Phenotype ◽  
Wing Margin ◽  
Transcriptional Enhancer ◽  
Organ Differentiation ◽  
Notch Activity ◽  
Neural Fate ◽  
Drosophila Wing

Abstract A number of wing scalloping mutations have been examined to determine their effects on the mutant phenotype of cut mutations and on the expression of the Cut protein. The mutations fall into two broad classes, those which interact synergistically with weak cut wing mutations to produce a more extreme wing phenotype than either mutation alone and those that have a simple additive effect with weak cut wing mutations. The synergistically interacting mutations are alleles of the Notch, Serrate and scalloped genes. These mutations affect development of the wing margin in a manner similar to the cut wing mutations. The mutations inactivate the cut transcriptional enhancer for the wing margin mechanoreceptors and noninnervated bristles and prevent differentiation of the organs. Surprisingly, reduction of Notch activity in the wing margin does not have the effect of converting epidermal cells to a neural fate as it does in other tissues of ectodermal origin. Rather, it prevents the differentiation of the wing margin mechanoreceptors and noninnervated bristles.

scholarly journals Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation

2008 ◽  
Vol 22 (16) ◽  
pp. 2166-2171 ◽  
Author(s):  
J. Feller ◽  
A. Schneider ◽  
K. Schuster-Gossler ◽  
A. Gossler
Keyword(s):  
Presomitic Mesoderm ◽  
Boundary Formation ◽  
Notch Activity

scholarly journals A Gain-of-Function Suppressor Screen for Genes Involved in Dorsal–Ventral Boundary Formation in the Drosophila Wing

Genetics ◽  
2008 ◽  
Vol 178 (1) ◽  
pp. 307-323 ◽  
Author(s):  
Fernando Bejarano ◽  
Carlos M. Luque ◽  
Héctor Herranz ◽  
Georgina Sorrosal ◽  
Neus Rafel ◽  
...  
Keyword(s):  
Gain Of Function ◽  
Boundary Formation ◽  
Drosophila Wing ◽  
Suppressor Screen

scholarly journals In-Vivo Imaging of the Drosophila Wing Imaginal Disc over Time: Novel Insights on Growth and Boundary Formation

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47594 ◽  
Author(s):  
Ulrike Nienhaus ◽  
Tinri Aegerter-Wilmsen ◽  
Christof M. Aegerter
Keyword(s):  
In Vivo Imaging ◽  
Imaginal Disc ◽  
Wing Imaginal Disc ◽  
Boundary Formation ◽  
Drosophila Wing ◽  
Over Time

scholarly journals Son of Notch, a Winged-helix Gene Involved in Boundary Formation in the Drosophila Wing

IUBMB Life ◽  
2007 ◽  
Vol 59 (12) ◽  
pp. 781-790
Author(s):  
Eungsik Park ◽  
Hyunsuk Suh ◽  
Changsoo Kim ◽  
Seungwoo Park ◽  
Dale Dorsett ◽  
...  
Keyword(s):  
Winged Helix ◽  
Boundary Formation ◽  
Drosophila Wing

Relationships between extramacrochaetae and Notch signalling in Drosophila wing development

Development ◽  
2000 ◽  
Vol 127 (11) ◽  
pp. 2383-2393 ◽  
Author(s):  
A. Baonza ◽  
J.F. de Celis ◽  
A. Garcia-Bellido
Keyword(s):  
Cell Proliferation ◽  
Genetic Interaction ◽  
Wing Disc ◽  
Notch Signalling ◽  
Wing Development ◽  
Notch Activity ◽  
Drosophila Wing ◽  
Vein Formation ◽  
Gene Enhancer ◽  
Enhancer Of Split

The function of extramacrochaetae is required during the development of the Drosophila wing in processes such as cell proliferation and vein differentiation. extramacrochaetae encodes a transcription factor of the HLH family, but unlike other members of this family, Extramacrochaetae lacks the basic region that is involved in interaction with DNA. Some phenotypes caused by extramacrochaetae in the wing are similar to those observed when Notch signalling is compromised. Furthermore, maximal levels of extramacrochaetae expression in the wing disc are restricted to places where Notch activity is higher, suggesting that extramacrochaetae could mediate some aspects of Notch signalling during wing development. We have studied the relationships between extramacrochaetae and Notch in wing development, with emphasis on the processes of vein formation and cell proliferation. We observe strong genetic interaction between extramacrochaetae and different components of the Notch signalling pathway, suggesting a functional relationship between them. We show that the higher level of extramacrochaetae expression coincides with the domain of expression of Notch and its downstream gene Enhancer of split-m(beta). The expression of extramacrochaetae at the dorso/ventral boundary and in boundary cells between veins and interveins depends on Notch activity. We propose that at least during vein differentiation and wing margin formation, extramacrochaetae is regulated by Notch and collaborates with other Notch-downstream genes such as Enhancer of split-m(beta).

scholarly journals The LRR Proteins Capricious and Tartan Mediate Cell Interactions during DV Boundary Formation in the Drosophila Wing

Cell ◽  
2001 ◽  
Vol 106 (6) ◽  
pp. 785-794 ◽  
Author(s):  
Marco Milán ◽  
Ulrich Weihe ◽  
Lidia Pérez ◽  
Stephen M. Cohen
Keyword(s):  
Cell Interactions ◽  
Boundary Formation ◽  
Drosophila Wing ◽  
Mediate Cell

scholarly journals Robustness and Stability of the Gene Regulatory Network Involved in DV Boundary Formation in the Drosophila Wing

PLoS ONE ◽  
2007 ◽  
Vol 2 (7) ◽  
pp. e602 ◽  
Author(s):  
Javier Buceta ◽  
Héctor Herranz ◽  
Oriol Canela-Xandri ◽  
Ramon Reigada ◽  
Francesc Sagués ◽  
...  
Keyword(s):  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Boundary Formation ◽  
Drosophila Wing ◽  
Gene Regulatory

Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing

Development ◽  
2011 ◽  
Vol 138 (17) ◽  
pp. 3781-3789 ◽  
Author(s):  
I. Becam ◽  
N. Rafel ◽  
X. Hong ◽  
S. M. Cohen ◽  
M. Milan
Keyword(s):  
Boundary Formation ◽  
Drosophila Wing
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