scholarly journals Spatial buffering of light-evoked potassium increases by retinal Muller (glial) cells

Science ◽  
1989 ◽  
Vol 244 (4904) ◽  
pp. 578-580 ◽  
Author(s):  
C. Karwoski ◽  
H. Lu ◽  
E. Newman
Keyword(s):  
Glial Cells ◽  
Müller Glial Cells ◽  
Spatial Buffering

scholarly journals Reaccumulation of [K+]o in the toad retina during maintained illumination.

1984 ◽  
Vol 84 (3) ◽  
pp. 475-504 ◽  
Author(s):  
H Shimazaki ◽  
B Oakley
Keyword(s):  
Differential Equations ◽  
Glial Cells ◽  
Time Course ◽  
Subretinal Space ◽  
Light Onset ◽  
Müller Glial Cells ◽  
Isolated Retina ◽  
Steady Level ◽  
Spatial Buffering ◽  
Toad Bufo

Using K+-selective microelectrodes, [K+]o was measured in the subretinal space of the isolated retina of the toad, Bufo marinus. During maintained illumination, [K+]o fell to a minimum and then recovered to a steady level that was approximately 0.1 mM below its dark level. Spatial buffering of [K+]o by Müller (glial) cells could contribute to this reaccumulation of K+. However, superfusion with substances that might be expected to block glial transport of K+ had no significant effect upon the reaccumulation of K+. These substances included blockers of gK (TEA+, Cs+, Rb+, 4-AP) and a gliotoxin (alpha AAA). Progressive slowing of the rods' Na+/K+ pump (perhaps caused by a light-evoked decrease in [Na+]i) also could contribute to this reaccumulation of K+ by reducing the uptake of K+ from the subretinal space. As evidence for a major contribution by this mechanism, treatments designed to prevent such slowing of the pump reversibly blocked reaccumulation. These treatments included superfusion with 2 microM ouabain, or lowering [K+]o, PO2, or temperature. It is likely that such treatments inhibit the pump, increase [Na+]i, and attenuate any light-evoked decrease in [Na+]i. The results are consistent with the following hypothesis. At light onset, the decrease in rod gNa will reduce the Na+ influx and the resulting rod hyperpolarization will reduce the K+ efflux. In combination with these reduced passive fluxes, the continuing active fluxes will lower both [K+]o and [Na+]i, which in turn will inhibit the pump. In support of this hypothesis, the solutions to a pair of coupled differential equations that model changes in both [K+]o and [Na+]i match quantitatively the time course of the observed changes in [K+]o during and after maintained illumination for all stimuli examined.

Spatial buffering of extracellular potassium by Müller (glial) cells in the toad retina

1992 ◽  
Vol 55 (4) ◽  
pp. 539-550 ◽  
Author(s):  
Burks Oakley ◽  
Bradley J. Katz ◽  
Zhian Xu ◽  
Jianbiao Zheng
Keyword(s):  
Glial Cells ◽  
Extracellular Potassium ◽  
Müller Glial Cells ◽  
Spatial Buffering

What do retinal Müller (glial) cells do for their neuronal ‘small siblings’?

1993 ◽  
Vol 6 (4) ◽  
pp. 201-213 ◽  
Author(s):  
A. Reichenbach ◽  
J.-U. Stolzenburg ◽  
W. Eberhardt ◽  
T.I. Chao ◽  
D. Dettmer ◽  
...  
Keyword(s):  
Glial Cells ◽  
Müller Glial Cells

GABAA receptor currents recorded from Müller glial cells of the baboon (Papio cynocephalus) retina

1996 ◽  
Vol 203 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Winfried Reichelt ◽  
Miguel Hernandez ◽  
Raymond T. Damian ◽  
William S. Kisaalita ◽  
Berry L. Jordan
Keyword(s):  
Gabaa Receptor ◽  
Glial Cells ◽  
Papio Cynocephalus ◽  
Müller Glial Cells

Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization

2005 ◽  
Vol 81 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Alejandro Caicedo ◽  
Diego G. Espinosa-Heidmann ◽  
Yolanda Piña ◽  
Eleut P. Hernandez ◽  
Scott W. Cousins
Keyword(s):  
Choroidal Neovascularization ◽  
Glial Cells ◽  
Müller Glial Cells

The glutathione content of retinal Müller (glial) cells: effect of pathological conditions

2000 ◽  
Vol 36 (4-5) ◽  
pp. 461-469 ◽  
Author(s):  
Dominik Huster ◽  
Andreas Reichenbach ◽  
Winfried Reichelt
Keyword(s):  
Glial Cells ◽  
Müller Glial Cells ◽  
Pathological Conditions
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