Osteoclastic bone resorption by a polarized vacuolar proton pump

Science ◽  
1989 ◽  
Vol 245 (4920) ◽  
pp. 855-857 ◽  
Author(s):  
H. Blair ◽  
S. Teitelbaum ◽  
R Ghiselli ◽  
S Gluck
Keyword(s):  
Bone Resorption ◽  
Proton Pump ◽  
Osteoclastic Bone Resorption ◽  
Vacuolar Proton Pump

scholarly journals Cytoplasmic Terminus of Vacuolar Type Proton Pump Accessory Subunit Ac45 Is Required for Proper Interaction with V0Domain Subunits and Efficient Osteoclastic Bone Resorption

2008 ◽  
Vol 283 (19) ◽  
pp. 13194-13204 ◽  
Author(s):  
Haotian Feng ◽  
Taksum Cheng ◽  
Nathan J. Pavlos ◽  
Kirk H. M. Yip ◽  
Amerigo Carrello ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Proton Pump ◽  
Osteoclastic Bone Resorption ◽  
Accessory Subunit

Characterization of a Cell Line Derived From a Human Giant Cell Tumor That Stimulates Osteoclastic Bone Resorption

1993 ◽  
Vol &NA; (296) ◽  
pp. 229???241 ◽  
Author(s):  
RICHARD O. C. OREFFO ◽  
G. JUNE MARSHALL ◽  
MARY KIRCHEN ◽  
CARLOS GARCIA ◽  
WOLF E. GALLWITZ ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Giant Cell Tumor ◽  
Cell Line ◽  
Giant Cell ◽  
Cell Tumor ◽  
Osteoclastic Bone Resorption ◽  
A Cell

Minocycline to be used a potential anti-bone resorption agents due to the suppression of osteoclastic bone resorption

2013 ◽  
Vol 55 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Nobuyuki Udagawa ◽  
Masanori Koide ◽  
Midori Nakamura ◽  
Naoyuki Takahashi
Keyword(s):  
Bone Resorption ◽  
Osteoclastic Bone Resorption

scholarly journals Regulatory assembly of the vacuolar proton pump V o V 1 -ATPase in yeast cells by FLIM-FRET

2010 ◽  
Author(s):  
Stefan Ernst ◽  
Claire Batisse ◽  
Nawid Zarrabi ◽  
Bettina Böttcher ◽  
Michael Börsch
Keyword(s):  
Proton Pump ◽  
Yeast Cells ◽  
Vacuolar Proton Pump

Simplified Approach to Enzymatic Identification of Osteoclastic Bone Resorption

1991 ◽  
Vol 14 (2) ◽  
pp. 81-83 ◽  
Author(s):  
Ian H. Parkinson ◽  
Nicola L. Fazzalari ◽  
Timothy C. Durbridge ◽  
Robert J. Moore
Keyword(s):  
Bone Resorption ◽  
Osteoclastic Bone Resorption ◽  
Simplified Approach

scholarly journals Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption

2018 ◽  
Vol 9 ◽  
Author(s):  
Brendan F. Boyce ◽  
Jinbo Li ◽  
Lianping Xing ◽  
Zhenqiang Yao
Keyword(s):  
Bone Resorption ◽  
Bone Remodeling ◽  
Osteoclastic Bone Resorption

The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction

2003 ◽  
Vol 284 (3) ◽  
pp. C667-C673 ◽  
Author(s):  
Alexander Pushkin ◽  
Natalia Abuladze ◽  
Debra Newman ◽  
Vladimir Muronets ◽  
Pejvak Sassani ◽  
...  
Keyword(s):  
Amino Acid ◽  
Proton Pump ◽  
Rat Kidney ◽  
Pdz Domain ◽  
Intercalated Cells ◽  
Regulatory Factor ◽  
Atpase Subunit ◽  
Sodium Bicarbonate Cotransporter ◽  
Terminal Amino ◽  
Vacuolar Proton Pump

The electroneutral sodium bicarbonate cotransporter 3 (NBC3) coimmunoprecipitates from renal lysates with the vacuolar H+-ATPase. In renal type A and B intercalated cells, NBC3 colocalizes with the vacuolar H+-ATPase. The involvement of the COOH termini of NBC3 and the 56-kDa subunit of the proton pump in the interaction of these proteins was investigated. The intact and modified COOH termini of NBC3 and the 56-kDa subunit of the proton pump were synthesized, coupled to Sepharose beads, and used to pull down kidney membrane proteins. Both the 56- and the 70-kDa subunits of the proton pump, as well as a PDZ domain containing protein Na+/H+ exchanger regulatory factor 1 (NHERF-1), were bound to the intact 18 amino acid NBC3 COOH terminus. A peptide truncated by five COOH-terminal amino acids did not bind these proteins. Replacement of the COOH-terminal leucine with glycine blocked binding of both the proton pump subunits but did not affect binding of NHERF-1. The 18 amino acid COOH terminus of the 56-kDa subunit of the proton pump bound NHERF-1 and NBC3, but the truncated and modified peptide did not. A complex of NBC3, the 56-kDa subunit of the proton pump, and NHERF-1 was identified in rat kidney. The data indicate that the COOH termini of NBC3 and the 56-kDa subunit of the vacuolar proton pump are PDZ-interacting motifs that are necessary for the interaction of these proteins. NHERF-1 is involved in the interaction of NBC3 and the vacuolar proton pump.

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