Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to Gp120

Science ◽  
1991 ◽  
Vol 254 (5028) ◽  
pp. 105-108 ◽  
Author(s):  
K. Steimer ◽  
C. Scandella ◽  
P. Skiles ◽  
N. Haigwood
Keyword(s):  
Human Antibodies ◽  
Hiv 1

Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions

AIDS ◽  
2002 ◽  
Vol 16 (18) ◽  
pp. 2409-2417 ◽  
Author(s):  
Lisa A Cavacini ◽  
Mark Duval ◽  
James Robinson ◽  
Marshall R Posner
Keyword(s):  
Antibody Binding ◽  
Primary Isolate ◽  
Human Antibodies ◽  
Hiv 1

scholarly journals Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

EBioMedicine ◽  
2014 ◽  
Vol 1 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Susan Zolla-Pazner ◽  
Paul T. Edlefsen ◽  
Morgane Rolland ◽  
Xiang-Peng Kong ◽  
Allan deCamp ◽  
...  
Keyword(s):  
Variable Region ◽  
Human Antibodies ◽  
The Third ◽  
Immune Pressure ◽  
Hiv 1

scholarly journals Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

2020 ◽  
Author(s):  
Ryan S. Roark ◽  
Hui Li ◽  
Wilton B. Williams ◽  
Hema Chug ◽  
Rosemarie D. Mason ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Rhesus Macaques ◽  
Virus Antibody ◽  
Human Antibodies ◽  
Immunogen Design ◽  
Cd4 Binding Site ◽  
Human Immunodeficiency Viruses ◽  
Chemical Solutions ◽  
Developmental Features ◽  
Hiv 1

ABSTRACTNeutralizing antibodies elicited by HIV-1 coevolve with viral Envs in distinctive patterns, in some cases acquiring substantial breadth. Here we show that primary HIV-1 Envs, when expressed by simian-human immunodeficiency viruses in rhesus macaques, elicited patterns of Env-antibody coevolution strikingly similar to those in humans. This included conserved immunogenetic, structural and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2-apex mode of recognition like that of human bNAbs PGT145/PCT64-35M. Another rhesus antibody bound the CD4-binding site by CD4 mimicry mirroring human bNAbs 8ANC131/CH235/VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.One sentence summaryVirus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

scholarly journals Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158861 ◽  
Author(s):  
Mark D. Hicar ◽  
Xuemin Chen ◽  
Chidananda Sulli ◽  
Trevor Barnes ◽  
Jason Goodman ◽  
...  
Keyword(s):  
Human Antibodies ◽  
Env Protein ◽  
Hiv 1

HIV-1 mutants escaping neutralization by the human antibodies 2F5, 2G12, and 4E10: in vitro experiments versus clinical studies

AIDS ◽  
2005 ◽  
Vol 19 (17) ◽  
pp. 1957-1966 ◽  
Author(s):  
Sabine Nakowitsch ◽  
Heribert Quendler ◽  
Helga Fekete ◽  
Renate Kunert ◽  
Hermann Katinger ◽  
...  
Keyword(s):  
Clinical Studies ◽  
In Vitro Experiments ◽  
Human Antibodies ◽  
Hiv 1

scholarly journals Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

Immunity ◽  
2012 ◽  
Vol 37 (3) ◽  
pp. 412-425 ◽  
Author(s):  
Peter D. Kwong ◽  
John R. Mascola
Keyword(s):  
B Cell ◽  
Human Antibodies ◽  
Hiv 1

Map of Sequential B Cell Epitopes of the HIV-1 Transmembrane Protein Using Human Antibodies as Probe

Intervirology ◽  
1990 ◽  
Vol 31 (6) ◽  
pp. 327-338 ◽  
Author(s):  
Jaap Goudsmit ◽  
Rob H. Meloen ◽  
Robert Brasseur
Keyword(s):  
B Cell ◽  
Transmembrane Protein ◽  
B Cell Epitopes ◽  
Human Antibodies ◽  
Hiv 1
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