Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade

Y Zhong; C. Wu

doi:10.1126/science.1670967

Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3′,5′-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice

Neuroscience ◽

10.1016/j.neuroscience.2005.02.042 ◽

2005 ◽

Vol 133 (2) ◽

pp. 591-604 ◽

Cited By ~ 31

Author(s):

H. Badie-Mahdavi ◽

X. Lu ◽

M.M. Behrens ◽

T. Bartfai

Keyword(s):

Synaptic Plasticity ◽

Cyclic Amp ◽

Dentate Gyrus ◽

Protein Phosphorylation ◽

Knockout Mice ◽

Galanin Receptor ◽

Element Binding Protein ◽

Cyclic Amp Response Element ◽

Galanin Receptor 1

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Cyclic AMP and Afferent Activity Govern Bidirectional Synaptic Plasticity in Striatopallidal Neurons

Journal of Neuroscience ◽

10.1523/jneurosci.3906-13.2014 ◽

2014 ◽

Vol 34 (19) ◽

pp. 6692-6699 ◽

Cited By ~ 14

Author(s):

S. M. Augustin ◽

J. A. Beeler ◽

D. S. McGehee ◽

X. Zhuang

Keyword(s):

Synaptic Plasticity ◽

Cyclic Amp ◽

Afferent Activity

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Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila

Journal of Comparative Physiology A ◽

10.1007/s00359-006-0200-z ◽

2006 ◽

Vol 193 (2) ◽

pp. 279-283 ◽

Cited By ~ 5

Author(s):

Katsunori Motosaka ◽

Masayuki Koganezawa ◽

Satoko Narikawa ◽

Akira Furuyama ◽

Kenji Shinozaki ◽

...

Keyword(s):

Cyclic Amp ◽

Food Choice ◽

Choice Behavior ◽

Memory Mutants

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Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases

Progress in Neurobiology ◽

10.1016/j.pneurobio.2003.12.003 ◽

2003 ◽

Vol 71 (6) ◽

pp. 401-437 ◽

Cited By ~ 198

Author(s):

P.V Nguyen ◽

N.H Woo

Keyword(s):

Synaptic Plasticity ◽

Cyclic Amp ◽

Protein Kinases ◽

Hippocampal Synaptic Plasticity ◽

Dependent Protein

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Opposite regulation by the β-adrenoceptor-cyclic amp system of synaptic plasticity in the medial and lateral amygdala in vitro

Neuroscience ◽

10.1016/0306-4522(95)00498-x ◽

1996 ◽

Vol 71 (4) ◽

pp. 1031-1035 ◽

Cited By ~ 12

Author(s):

Y. Watanabe ◽

Y. Ikegaya ◽

H. Saito ◽

K. Abe

Keyword(s):

Synaptic Plasticity ◽

Cyclic Amp ◽

Lateral Amygdala ◽

Amp System

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A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus

Journal of Neuroscience ◽

10.1523/jneurosci.14-05-03310.1994 ◽

1994 ◽

Vol 14 (5) ◽

pp. 3310-3318 ◽

Cited By ~ 44

Author(s):

RW Gereau ◽

PJ Conn

Keyword(s):

Synaptic Plasticity ◽

Cyclic Amp ◽

Glutamate Receptors ◽

Adrenergic Receptors ◽

Metabotropic Glutamate Receptors ◽

Rat Hippocampus ◽

Beta Adrenergic Receptors ◽

Beta Adrenergic ◽

Metabotropic Glutamate ◽

Dependent Form

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Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079590 ◽

1977 ◽

Vol 35 ◽

pp. 430-431

Author(s):

L.S. Cutler

Keyword(s):

Cyclic Amp ◽

Adenylate Cyclase ◽

Submandibular Gland ◽

Neonatal Rat ◽

Cyclase Activity ◽

Adenylate Cyclase Activity ◽

Parotid Glands ◽

Adrenergic Agonist ◽

Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

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Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Biochemical Society Transactions ◽

10.1042/bst20190246 ◽

2019 ◽

Vol 47 (6) ◽

pp. 1733-1747 ◽

Cited By ~ 3

Author(s):

Christina Klausen ◽

Fabian Kaiser ◽

Birthe Stüven ◽

Jan N. Hansen ◽

Dagmar Wachten

Keyword(s):

Cyclic Amp ◽

Adenosine Monophosphate ◽

Adenylyl Cyclases ◽

Temporal Precision ◽

Fluorescent Biosensors ◽

Subcellular Domains ◽

Spatio Temporal ◽

Hydrolysis Of ◽

Shed Light ◽

Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

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