Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump

Science ◽  
1992 ◽  
Vol 258 (5082) ◽  
pp. 665-667 ◽  
Author(s):  
S. Johnson ◽  
V Seutin ◽  
R. North
Keyword(s):  
Sodium Pump ◽  
Burst Firing ◽  
Dopamine Neurons ◽  
Electrogenic Sodium Pump

Mammalian cold receptor afferents: role of an electrogenic sodium pump in sensory transduction

1974 ◽  
Vol 73 (1) ◽  
pp. 156-160 ◽  
Author(s):  
Friedrich-Karl Pierau ◽  
Peter Torrey ◽  
David O. Carpenter
Keyword(s):  
Sodium Pump ◽  
Sensory Transduction ◽  
Cold Receptor ◽  
Electrogenic Sodium Pump

scholarly journals Photoreception in Limulus: Role of an Electrogenic Sodium Pump?

Science ◽  
1969 ◽  
Vol 164 (3884) ◽  
pp. 1188-1189 ◽  
Author(s):  
G. Duncan ◽  
S. L. Bonting ◽  
T. G. Smith ◽  
J. E. Brown ◽  
W. K. Stell ◽  
...  
Keyword(s):  
Sodium Pump ◽  
Electrogenic Sodium Pump

The role of the electrogenic sodium pump in modulation of pacemaker discharge ofAplysia neurons

1974 ◽  
Vol 84 (3) ◽  
pp. 463-471 ◽  
Author(s):  
James A. Willis ◽  
Gary L. Gaubatz ◽  
David O. Carpenter
Keyword(s):  
Sodium Pump ◽  
Electrogenic Sodium Pump

scholarly journals Withdrawal From Intermittent Ethanol Exposure Increases Probability of Burst Firing in VTA Neurons In Vitro

2007 ◽  
Vol 98 (4) ◽  
pp. 2297-2310 ◽  
Author(s):  
F. Woodward Hopf ◽  
Miquel Martin ◽  
Billy T. Chen ◽  
M. Scott Bowers ◽  
Maysha M. Mohamedi ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Burst Firing ◽  
Dopamine Neurons ◽  
Calcium Dependent ◽  
Physiological Properties ◽  
Seeking Behavior ◽  
Delayed Recovery ◽  
Small Conductance

Changing the activity of ventral tegmental area (VTA) dopamine neurons from pacemaker to burst firing is hypothesized to increase the salience of stimuli, such as an unexpected reward, and likely contributes to withdrawal-associated drug-seeking behavior. Accordingly, pharmacological, behavioral, and electrophysiological data suggest an important role of the VTA in mediating alcohol-dependent behaviors. However, the effects of repeated ethanol exposure on VTA dopamine neuron ion channel function are poorly understood. Here, we repeatedly exposed rats to ethanol (2 g/kg ethanol, ip, twice per day for 5 days), then examined the firing patterns of VTA dopamine neurons in vitro after 7 days withdrawal. Compared with saline-treated animals, the function of the small conductance calcium-dependent potassium channel (SK) was reduced in ethanol-treated animals. Consistent with a role for SK in regulation of burst firing, NMDA applied during firing facilitated the transition to bursting in ethanol-treated but not saline-treated animals; NMDA consistently induced bursting only in saline-treated animals when SK was inhibited. Also, enhanced bursting in ethanol-treated animals was not a result of differences in NMDA-induced depolarization. Further, Ih was also reduced in ethanol-treated animals, which delayed recovery from hyperpolarization, but did not account for the increased NMDA-induced bursting in ethanol-treated animals. Finally, repeated ethanol exposure and withdrawal also enhanced the acute locomotor-activating effect of cocaine (15 mg/kg, ip). Thus withdrawal after repeated ethanol exposure produced several alterations in the physiological properties of VTA dopamine neurons, which could ultimately increase the ability of VTA neurons to produce burst firing and thus might contribute to addiction-related behaviors.

Role of electrogenic sodium pump in slow synaptic inhibition is re-evaluated

Nature ◽  
1977 ◽  
Vol 267 (5606) ◽  
pp. 68-70 ◽  
Author(s):  
PETER A. SMITH ◽  
FORREST F. WEIGHT
Keyword(s):  
Sodium Pump ◽  
Synaptic Inhibition ◽  
Electrogenic Sodium Pump
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