scholarly journals Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

Science ◽  
2014 ◽  
Vol 343 (6169) ◽  
pp. 432-437 ◽  
Author(s):  
S. P. Spencer ◽  
C. Wilhelm ◽  
Q. Yang ◽  
J. A. Hall ◽  
N. Bouladoux ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Micronutrient Deficiency ◽  
Lymphoid Cells ◽  
Barrier Immunity

scholarly journals Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

2016 ◽  
Vol 213 (8) ◽  
pp. 1409-1418 ◽  
Author(s):  
Christoph Wilhelm ◽  
Oliver J. Harrison ◽  
Vanessa Schmitt ◽  
Martin Pelletier ◽  
Sean P. Spencer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Helminth Infection ◽  
Critical Role ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Environmental Signals ◽  
Essential Nutrient ◽  
Barrier Immunity

Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little is known about the metabolism of ILC and whether these cells can metabolically adapt in response to environmental signals. Here we show that type 2 innate lymphoid cells (ILC2), important mediators of barrier immunity, predominantly depend on fatty acid (FA) metabolism during helminth infection. Further, in situations where an essential nutrient, such as vitamin A, is limited, ILC2 sustain their function and selectively maintain interleukin 13 (IL-13) production via increased acquisition and utilization of FA. Together, these results reveal that ILC2 preferentially use FAs to maintain their function in the context of helminth infection or malnutrition and propose that enhanced FA usage and FA-dependent IL-13 production by ILC2 could represent a host adaptation to maintain barrier immunity under dietary restriction.

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1886-P
Author(s):  
MASANORI FUJIMOTO ◽  
KOUTARO YOKOTE ◽  
TOMOAKI TANAKA
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells
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