ESCRT Machinery Is Required for Plasma Membrane Repair

Science ◽  
2014 ◽  
Vol 343 (6174) ◽  
pp. 1247136-1247136 ◽  
Author(s):  
A. J. Jimenez ◽  
P. Maiuri ◽  
J. Lafaurie-Janvore ◽  
S. Divoux ◽  
M. Piel ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Membrane Repair ◽  
Escrt Machinery ◽  
Plasma Membrane Repair

scholarly journals Plasma membrane repairs by small GTPase Rab3a

2016 ◽  
Vol 213 (6) ◽  
pp. 613-615 ◽  
Author(s):  
Camilla Raiborg ◽  
Harald Stenmark
Keyword(s):  
Plasma Membrane ◽  
Small Gtpase ◽  
Membrane Repair ◽  
Cell Biol ◽  
Plasma Membrane Repair

Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane repair.

scholarly journals Mitochondrial fragmentation enables localized signaling required for cell repair

2020 ◽  
Vol 219 (5) ◽  
Author(s):  
Adam Horn ◽  
Shreya Raavicharla ◽  
Sonna Shah ◽  
Dan Cox ◽  
Jyoti K. Jaiswal
Keyword(s):  
Plasma Membrane ◽  
Calcium Influx ◽  
Cell Damage ◽  
Mitochondrial Fission ◽  
Adaptor Protein ◽  
Mitochondrial Fragmentation ◽  
Membrane Repair ◽  
Membrane Injury ◽  
Mitochondrial Signaling ◽  
Plasma Membrane Repair

Plasma membrane injury can cause lethal influx of calcium, but cells survive by mounting a polarized repair response targeted to the wound site. Mitochondrial signaling within seconds after injury enables this response. However, as mitochondria are distributed throughout the cell in an interconnected network, it is unclear how they generate a spatially restricted signal to repair the plasma membrane wound. Here we show that calcium influx and Drp1-mediated, rapid mitochondrial fission at the injury site help polarize the repair response. Fission of injury-proximal mitochondria allows for greater amplitude and duration of calcium increase in these mitochondria, allowing them to generate local redox signaling required for plasma membrane repair. Drp1 knockout cells and patient cells lacking the Drp1 adaptor protein MiD49 fail to undergo injury-triggered mitochondrial fission, preventing polarized mitochondrial calcium increase and plasma membrane repair. Although mitochondrial fission is considered to be an indicator of cell damage and death, our findings identify that mitochondrial fission generates localized signaling required for cell survival.

scholarly journals Annexin A7 is required for ESCRT III-mediated plasma membrane repair

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Stine Lauritzen Sønder ◽  
Theresa Louise Boye ◽  
Regine Tölle ◽  
Jörn Dengjel ◽  
Kenji Maeda ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Membrane Repair ◽  
Plasma Membrane Repair ◽  
Annexin A7

Plasma membrane repair and cellular damage control: The annexin survival kit

2011 ◽  
Vol 81 (6) ◽  
pp. 703-712 ◽  
Author(s):  
Annette Draeger ◽  
Katia Monastyrskaya ◽  
Eduard B. Babiychuk
Keyword(s):  
Plasma Membrane ◽  
Damage Control ◽  
Cellular Damage ◽  
Membrane Repair ◽  
Plasma Membrane Repair

An actin-dependent annexin complex mediates plasma membrane repair in muscle

2016 ◽  
Vol 213 (7) ◽  
pp. 2137OIA58 ◽  
Author(s):  
Alexis R. Demonbreun ◽  
Mattia Quattrocelli ◽  
David Y. Barefield ◽  
Madison V. Allen ◽  
Kaitlin E. Swanson ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Membrane Repair ◽  
Plasma Membrane Repair
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