Hierarchical Porous Polymer Scaffolds from Block Copolymers

Science ◽  
2013 ◽  
Vol 341 (6145) ◽  
pp. 530-534 ◽  
Author(s):  
H. Sai ◽  
K. W. Tan ◽  
K. Hur ◽  
E. Asenath-Smith ◽  
R. Hovden ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Porous Polymer ◽  
Polymer Scaffolds ◽  
Hierarchical Porous

Hierarchical porous SiOC via freeze casting and self-assembly of block copolymers

2021 ◽  
Vol 191 ◽  
pp. 204-209 ◽  
Author(s):  
Taijung Kuo ◽  
Lisa M. Rueschhoff ◽  
Matthew B. Dickerson ◽  
Tulsi A. Patel ◽  
Katherine T. Faber
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Freeze Casting ◽  
Hierarchical Porous

scholarly journals Robocasting of Single and Multi-Functional Calcium Phosphate Scaffolds and Its Hybridization with Conventional Techniques: Design, Fabrication and Characterization

2020 ◽  
Vol 10 (23) ◽  
pp. 8677
Author(s):  
Mehdi Mohammadi ◽  
Patricia Pascaud-Mathieu ◽  
Valeria Allizond ◽  
Jean-Marc Tulliani ◽  
Bartolomeo Coppola ◽  
...  
Keyword(s):  
Surrounding Medium ◽  
Silver Ions ◽  
Octacalcium Phosphate ◽  
Hybrid Structure ◽  
Functionally Graded ◽  
Porous Polymer ◽  
Polymer Layer ◽  
Polymer Scaffolds ◽  
Salt Leaching ◽  
Porous Part

In this work, dense, porous, and, for the first time, functionally-graded bi-layer scaffolds with a cylindrical geometry were produced from a commercially available hydroxyapatite powder using the robocasting technique. The bi-layer scaffolds were made of a dense core part attached to a surrounding porous part. Subsequently, these bi-layer robocast scaffolds were joined with an outer shell of an antibacterial porous polymer layer fabricated by solvent casting/salt leaching techniques, leading to hybrid ceramic-polymer scaffolds. The antibacterial functionality was achieved through the addition of silver ions to the polymer layer. All the robocast samples, including the bi-layer ones, were first characterized through scanning electron microscopy observations, mechanical characterization in compression and preliminary bioactivity tests. Then, the hybrid bi-layer ceramic-polymer scaffolds were characterized through antimicrobial tests. After sintering at 1300 °C for 3 h, the compressive strengths of the structures were found to be equal to 29 ± 4 MPa for dense samples and 7 ± 4 MPa for lattice structures with a porosity of 34.1%. Bioactivity tests performed at 37 °C for 4 weeks showed that the precipitated layer on the robocast samples contained octacalcium phosphate. Finally, it was evidenced that the hybrid structure was effective in releasing antibacterial Ag+ ions to the surrounding medium showing its potential efficiency in limiting Staphylococcus aureus proliferation during surgery.

Microarchitectural and mechanical characterization of oriented porous polymer scaffolds

Biomaterials ◽  
2003 ◽  
Vol 24 (3) ◽  
pp. 481-489 ◽  
Author(s):  
Angela S.P Lin ◽  
Thomas H Barrows ◽  
Sarah H Cartmell ◽  
Robert E Guldberg
Keyword(s):  
Mechanical Characterization ◽  
Porous Polymer ◽  
Polymer Scaffolds

Cell colonization of scaffolds for tissue engineering enhanced by means of plasma processes

2012 ◽  
Vol 1469 ◽  
Author(s):  
P. Favia ◽  
E. Sardella ◽  
R.A.H. Salama ◽  
V. R. Giampietro ◽  
F. Intranuovo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Adhesion ◽  
Plasma Deposition ◽  
Porous Polymer ◽  
Polymer Scaffolds ◽  
Natural Polymers ◽  
Biodegradable Scaffolds ◽  
Ft Ir ◽  
Cell Colonization

ABSTRACTSynthetic biodegradable polymers are commonly used as scaffolds for tissue engineering despite their poor cell adhesion compared to natural polymers. One of the problems in using biodegradable scaffolds is that a higher cell colonization at the scaffold periphery and inadequate colonization at its center is generally noted. Such aspects could seriously compromise the in vivo regeneration of a damaged tissue and, in turn, the success of the implant. Plasma processes have been lately proven as promising scaffold modification techniques. The current work aims at enhancing cell colonization in the core of polymer scaffolds via plasma deposition of coatings with different chemical characteristics. The versatility and ability of plasma processes to modify only the outermost layer of a material can render them competitive with respect to wet chemistry approaches in the field of biomedical materials. In this paper some of the results obtained by plasma processing of 3D interconnected porous polymer scaffolds for Tissue Engineering will be shown. In particular, it will be shown how it is possible to enhance cell adhesion, growth and colonization in porous Polycaprolactone (PCL) scaffolds where gradient of surface compositions are induced from the external (e.g., hydrophobic, slightly cell-repulsive) to the internal (e.g., hydrophilic, cell-adhesive) side of the scaffolds. 3D scaffolds were modified with several RF (13.56 MHz) deposition and treatment plasma processes. Materials were characterized by means of XPS, and FT-IR techniques. Cell-growth experiments were run with cell-lines to check the efficiency of several treatments to enhance/accelerate cell in-growth inside scaffolds.

scholarly journals Cargo-free scaffold implant recruits metastatic cancer cells via lung-mimicking myeloid cell S100A8/A9 axis

2019 ◽  
Author(s):  
Jing Wang ◽  
Matthew S. Hall ◽  
Grace G. Bushnell ◽  
Sophia M. Orbach ◽  
Ravi M. Raghani ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Metastatic Cancer ◽  
Gene Expression Signature ◽  
Myeloid Cell ◽  
Porous Polymer ◽  
Polymer Scaffolds ◽  
Tumor Bearing ◽  
Anti Cancer ◽  
Distant Tissue ◽  
Tissue Of Origin

AbstractPre-metastatic niches in distant tissue facilitate metastasis from the primary tumor. Cargo-free porous polymer scaffolds implanted in tumor-bearing mice act as synthetic metastatic niches recruiting metastasizing cancer cells. Herein, we investigated the mechanisms by which these implants attract cancer cells from circulation. Scaffolds attract cancer cells in part via S100A8/A9 secreted by Gr1+ myeloid cells in a mechanism that mimics lung metastasis. Further, cancer cells attracted to the scaffold have a lung-tropic gene expression signature regardless of their tissue of origin. The scaffold implant reduces metastasis to the lung suggesting otherwise lung-tropic cancer cells are diverted to the scaffold. The suppression of metastatic spread by the scaffold suggests this mechanism may be exploited for novel therapies, and may broadly influence the design of scaffold-based drug delivery system for anti-cancer therapy.

Human Osteoprogenitor Bone Formation Using Encapsulated Bone Morphogenetic Protein 2 in Porous Polymer Scaffolds

2004 ◽  
Vol 10 (7) ◽  
pp. 1037-1045 ◽  
Author(s):  
Xuebin B. Yang ◽  
Martin J. Whitaker ◽  
Walter Sebald ◽  
Nicholas Clarke ◽  
Steven M. Howdle ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Porous Polymer ◽  
Bone Morphogenetic Protein 2 ◽  
Polymer Scaffolds ◽  
Morphogenetic Protein

Development of organic solvent-free micro-/nano-porous polymer scaffolds for musculoskeletal regeneration

2017 ◽  
Vol 105 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
S. T. C. Lin ◽  
D. S. Musson ◽  
S. Amirapu ◽  
J. Cornish ◽  
D. Bhattacharyya
Keyword(s):  
Organic Solvent ◽  
Solvent Free ◽  
Porous Polymer ◽  
Polymer Scaffolds
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