Sequence-Controlled Polymers

Science ◽  
2013 ◽  
Vol 341 (6146) ◽  
pp. 1238149 ◽  
Author(s):  
Jean-François Lutz ◽  
Makoto Ouchi ◽  
David R. Liu ◽  
Mitsuo Sawamoto
Keyword(s):  
Data Storage ◽  
Self Assembly ◽  
Recent Progress ◽  
Chemical Nature ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Polymer Chemistry ◽  
Macroscopic Properties ◽  
Synthetic Macromolecules

Sequence-controlled polymers are macromolecules in which monomer units of different chemical nature are arranged in an ordered fashion. The most prominent examples are biological and have been studied and used primarily by molecular biologists and biochemists. However, recent progress in protein- and DNA-based nanotechnologies has shown the relevance of sequence-controlled polymers to nonbiological applications, including data storage, nanoelectronics, and catalysis. In addition, synthetic polymer chemistry has provided interesting routes for preparing nonnatural sequence-controlled polymers. Although these synthetic macromolecules do not yet compare in functional scope with their natural counterparts, they open up opportunities for controlling the structure, self-assembly, and macroscopic properties of polymer materials.

Electron-diffraction studies in synthetic polymer materials

1983 ◽  
Vol 41 ◽  
pp. 362-365
Author(s):  
D.T. Grubb
Keyword(s):  
Electron Diffraction ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Crystallographic Structure ◽  
High Dose ◽  
Electron Dose ◽  
Dose Rates ◽  
First Case ◽  
Diffraction Patterns ◽  
The Many

Diffraction studies in polymeric and other beam sensitive materials may bring to mind the many experiments where diffracted intensity has been used as a measure of the electron dose required to destroy fine structure in the TEM. But this paper is concerned with a range of cases where the diffraction pattern itself contains the important information.In the first case, electron diffraction from paraffins, degraded polyethylene and polyethylene single crystals, all the samples are highly ordered, and their crystallographic structure is well known. The diffraction patterns fade on irradiation and may also change considerably in a-spacing, increasing the unit cell volume on irradiation. The effect is large and continuous far C94H190 paraffin and for PE, while for shorter chains to C 28H58 the change is less, levelling off at high dose, Fig.l. It is also found that the change in a-spacing increases at higher dose rates and at higher irradiation temperatures.

scholarly journals Template-Free Self-Assembly of Two-Dimensional Polymers into Nano/Microstructured Materials

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3310
Author(s):  
Shengda Liu ◽  
Jiayun Xu ◽  
Xiumei Li ◽  
Tengfei Yan ◽  
Shuangjiang Yu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Recent Progress ◽  
Two Dimensional ◽  
Subsequent Removal ◽  
The Past ◽  
2D Polymers ◽  
Template Free ◽  
Self Assembled ◽  
The Relationship ◽  
Polymer Tubes

In the past few decades, enormous efforts have been made to synthesize covalent polymer nano/microstructured materials with specific morphologies, due to the relationship between their structures and functions. Up to now, the formation of most of these structures often requires either templates or preorganization in order to construct a specific structure before, and then the subsequent removal of previous templates to form a desired structure, on account of the lack of “self-error-correcting” properties of reversible interactions in polymers. The above processes are time-consuming and tedious. A template-free, self-assembled strategy as a “bottom-up” route to fabricate well-defined nano/microstructures remains a challenge. Herein, we introduce the recent progress in template-free, self-assembled nano/microstructures formed by covalent two-dimensional (2D) polymers, such as polymer capsules, polymer films, polymer tubes and polymer rings.

scholarly journals Recent progress in periodic patterning fabricated by self-assembly of colloidal spheres for optical applications

2020 ◽  
Vol 63 (8) ◽  
pp. 1418-1437 ◽  
Author(s):  
Jing Liu ◽  
Xingang Zhang ◽  
Wenqing Li ◽  
Changzhong Jiang ◽  
Ziyu Wang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Recent Progress ◽  
Colloidal Spheres ◽  
Optical Applications

scholarly journals 3D DNA structural barcode copying and random access

2020 ◽  
Author(s):  
Filip Bošković ◽  
Alexander Ohmann ◽  
Ulrich F. Keyser ◽  
Kaikai Chen
Keyword(s):  
Data Storage ◽  
Single Molecule ◽  
Self Assembly ◽  
Large Scale ◽  
Three Dimensional ◽  
Random Access ◽  
Scale Production ◽  
Digital Information ◽  
Dna Nanostructures ◽  
Large Scale Production

AbstractThree-dimensional (3D) DNA nanostructures built via DNA self-assembly have established recent applications in multiplexed biosensing and storing digital information. However, a key challenge is that 3D DNA structures are not easily copied which is of vital importance for their large-scale production and for access to desired molecules by target-specific amplification. Here, we build 3D DNA structural barcodes and demonstrate the copying and random access of the barcodes from a library of molecules using a modified polymerase chain reaction (PCR). The 3D barcodes were assembled by annealing a single-stranded DNA scaffold with complementary short oligonucleotides containing 3D protrusions at defined locations. DNA nicks in these structures are ligated to facilitate barcode copying using PCR. To randomly access a target from a library of barcodes, we employ a non-complementary end in the DNA construct that serves as a barcode-specific primer template. Readout of the 3D DNA structural barcodes was performed with nanopore measurements. Our study provides a roadmap for convenient production of large quantities of self-assembled 3D DNA nanostructures. In addition, this strategy offers access to specific targets, a crucial capability for multiplexed single-molecule sensing and for DNA data storage.

scholarly journals Evaluation of the suitability of synthetic polymer fuels in self-ignition engines

2019 ◽  
Vol 178 (3) ◽  
pp. 129-134
Author(s):  
Oleh KLYUS ◽  
Paweł KRAUSE ◽  
Vladimir MARKOV ◽  
Anna SKARBEK-ŻABKIN ◽  
Bowen SA
Keyword(s):  
Volume Fraction ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Physical Parameters ◽  
Sauter Mean Diameter ◽  
Synthetic Fuels ◽  
Limit Values ◽  
Experimental Part

The article presents a method for determining the quality of spraying a mixture of oil and synthetic fuels obtained from the pro-cessing of polymer materials. Laboratory tests of physical parameters of such a mixture were carried out, which made it possible to determine the limit values for the volume fraction of synthetic fuels. The method of determining the suitability of this type of fuel takes into account the criterion numbers Re and Oh, which include physical parameters such as viscosity, density, and surface tension. The experimental part concerning the distribution of droplets of injected fuel and determination of Sauter Mean Diameter using laser diffrac-tion confirmed the usefulness of the developed method for the assessment of the possibility of using a mixture of petroleum-based and synthetic fuels in self-ignition engines.

scholarly journals Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Luo ◽  
Yujuan Gao ◽  
Zhongyu Duan ◽  
Yu Yi ◽  
Hao Wang
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Recent Progress ◽  
Assembly Systems ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
Self Assembling ◽  
Stimuli Response

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

Biomimetic self-assembly of subcellular structures

2020 ◽  
Vol 56 (60) ◽  
pp. 8342-8354
Author(s):  
Shuying Yang ◽  
Lingxiang Jiang
Keyword(s):  
Self Assembly ◽  
Recent Progress ◽  
Isolated Systems

This article summarizes recent progress on biomimetic subcellular structures and discusses integration of these isolated systems.

Self-Assembly of the Synthetic Polymer (Leu-Glu)n:  An Amyloid-like Structure Formation

Langmuir ◽  
2003 ◽  
Vol 19 (8) ◽  
pp. 3413-3418 ◽  
Author(s):  
Julia P. Moses ◽  
K. S. Satheeshkumar ◽  
J. Murali ◽  
D. Alli ◽  
R. Jayakumar
Keyword(s):  
Structure Formation ◽  
Self Assembly ◽  
Synthetic Polymer

scholarly journals Reading mixtures of uniform sequence-defined macromolecules to increase data storage capacity

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Maximiliane Frölich ◽  
Dennis Hofheinz ◽  
Michael A. R. Meier
Keyword(s):  
Data Storage ◽  
Storage Capacity ◽  
Data Interpretation ◽  
Molecular Data ◽  
Research Topic ◽  
Side Chains ◽  
Esi Ms ◽  
Python Script ◽  
High Data ◽  
Synthetic Macromolecules

AbstractIn recent years, the field of molecular data storage has emerged from a niche to a vibrant research topic. Herein, we describe a simultaneous and automated read-out of data stored in mixtures of sequence-defined oligomers. Therefore, twelve different sequence-defined tetramers and three hexamers with different mass markers and side chains are successfully synthesised via iterative Passerini three-component reactions and subsequent deprotection steps. By programming a straightforward python script for ESI-MS/MS analysis, it is possible to automatically sequence and thus read-out the information stored in these oligomers within one second. Most importantly, we demonstrate that the use of mass-markers as starting compounds eases MS/MS data interpretation and furthermore allows the unambiguous reading of sequences of mixtures of sequence-defined oligomers. Thus, high data storage capacity considering the field of synthetic macromolecules (up to 64.5 bit in our examples) can be obtained without the need of synthesizing long sequences, but by mixing and simultaneously analysing shorter sequence-defined oligomers.

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