Molecular Basis of Age-Dependent Vernalization in Cardamine flexuosa

Science ◽  
2013 ◽  
Vol 340 (6136) ◽  
pp. 1097-1100 ◽  
Author(s):  
C.-M. Zhou ◽  
T.-Q. Zhang ◽  
X. Wang ◽  
S. Yu ◽  
H. Lian ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Age Dependent ◽  
Cardamine Flexuosa

scholarly journals Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Marta Maglione ◽  
Gaga Kochlamazashvili ◽  
Tobias Eisenberg ◽  
Bence Rácz ◽  
Eva Michael ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Memory Impairment ◽  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Age Related ◽  
Term Potentiation ◽  
Hippocampal Synapses ◽  
Age Dependent ◽  
Age Related Changes

AbstractAging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine.

scholarly journals Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

Cell ◽  
2014 ◽  
Vol 157 (6) ◽  
pp. 1405-1415 ◽  
Author(s):  
Agnieszka Szyk ◽  
Alexandra M. Deaconescu ◽  
Jeffrey Spector ◽  
Benjamin Goodman ◽  
Max L. Valenstein ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Age Dependent

scholarly journals Molecular Basis for Age-Dependent Acetylation by Tubulin Acetyltransferase

2015 ◽  
Vol 108 (2) ◽  
pp. 449a
Author(s):  
Jeffrey Spector ◽  
Agnieszka Szyk ◽  
Alexandra M. Deaconescu ◽  
Max Valenstein ◽  
Benjamin Goodman ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Age Dependent

scholarly journals Molecular basis of age-dependent gastric inactivation of rhesus rotavirus in the mouse.

1992 ◽  
Vol 89 (6) ◽  
pp. 1741-1745 ◽  
Author(s):  
D M Bass ◽  
M Baylor ◽  
R Broome ◽  
H B Greenberg
Keyword(s):  
Molecular Basis ◽  
Age Dependent

scholarly journals Molecular Basis for Age-Dependent Microtubule Acetylation

2015 ◽  
Vol 108 (2) ◽  
pp. 448a
Author(s):  
Antonina Roll-Mecak ◽  
Agnieszka Szyk ◽  
Alexandra Deaconescu ◽  
Jeffrey Spector ◽  
Max Valenstein ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Age Dependent

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

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