scholarly journals Comment on "Phonemic Diversity Supports a Serial Founder Effect Model of Language Expansion from Africa"

Science ◽  
2012 ◽  
Vol 335 (6069) ◽  
pp. 657-657 ◽  
Author(s):  
R. Van Tuyl ◽  
A. Pereltsvaig
Keyword(s):  
Founder Effect ◽  
Effect Model ◽  
Serial Founder Effect

scholarly journals Comment on "Phonemic Diversity Supports a Serial Founder Effect Model of Language Expansion from Africa"

Science ◽  
2012 ◽  
Vol 335 (6072) ◽  
pp. 1042-1042 ◽  
Author(s):  
T. F. Jaeger ◽  
D. Pontillo ◽  
P. Graff
Keyword(s):  
Founder Effect ◽  
Effect Model ◽  
Serial Founder Effect

scholarly journals A serial founder effect model for human settlement out of Africa

2008 ◽  
Vol 276 (1655) ◽  
pp. 291-300 ◽  
Author(s):  
Omkar Deshpande ◽  
Serafim Batzoglou ◽  
Marcus W Feldman ◽  
L Luca Cavalli-Sforza
Keyword(s):  
Genetic Diversity ◽  
Founder Effect ◽  
Published Data ◽  
Geographical Patterns ◽  
Effect Model ◽  
Occupied Territories ◽  
Out Of Africa ◽  
Serial Founder Effect ◽  
Parameter Values ◽  
Linear Decay

The increasing abundance of human genetic data has shown that the geographical patterns of worldwide genetic diversity are best explained by human expansion out of Africa. This expansion is modelled well by prolonged migration from a single origin in Africa with multiple subsequent serial founding events. We discuss a new simulation model for the serial founder effect out of Africa and compare it with results from previous studies. Unlike previous models, we distinguish colonization events from the continued exchange of people between occupied territories as a result of mating. We conduct a search through parameter space to estimate the range of parameter values that best explain key statistics from published data on worldwide variation in microsatellites. The range of parameters we use is chosen to be compatible with an out-of-Africa migration at 50–60 Kyr ago and archaeo–ethno–demographic information. In addition to a colonization rate of 0.09–0.18, for an acceptable fit to the published microsatellite data, incorporation into existing models of exchange between neighbouring populations is essential, but at a very low rate. A linear decay of genetic diversity with geographical distance from the origin of expansion could apply to any species, especially if it moved recently into new geographical niches.

scholarly journals Comment on "Phonemic Diversity Supports a Serial Founder Effect Model of Language Expansion from Africa"

Science ◽  
2012 ◽  
Vol 335 (6069) ◽  
pp. 657-657 ◽  
Author(s):  
C.-C. Wang ◽  
Q.-L. Ding ◽  
H. Tao ◽  
H. Li
Keyword(s):  
Founder Effect ◽  
Effect Model ◽  
Serial Founder Effect

scholarly journals Cooperation mitigates diversity loss in a spatially expanding microbial population

2019 ◽  
Vol 116 (47) ◽  
pp. 23582-23587 ◽  
Author(s):  
Saurabh R. Gandhi ◽  
Kirill S. Korolev ◽  
Jeff Gore
Keyword(s):  
Genetic Drift ◽  
Founder Effect ◽  
Microbial Population ◽  
Growth Dynamics ◽  
Low Density ◽  
Drastic Reduction ◽  
Diversity Loss ◽  
Abrupt Changes ◽  
Expanding Population ◽  
Serial Founder Effect

The evolution and potentially even the survival of a spatially expanding population depends on its genetic diversity, which can decrease rapidly due to a serial founder effect. The strength of the founder effect is predicted to depend strongly on the details of the growth dynamics. Here, we probe this dependence experimentally using a single microbial species, Saccharomyces cerevisiae, expanding in multiple environments that induce varying levels of cooperativity during growth. We observe a drastic reduction in diversity during expansions when yeast grows noncooperatively on simple sugars, but almost no loss of diversity when cooperation is required to digest complex metabolites. These results are consistent with theoretical expectations: When cells grow independently from each other, the expansion proceeds as a pulled wave driven by growth at the low-density tip of the expansion front. Such populations lose diversity rapidly because of the strong genetic drift at the expansion edge. In contrast, diversity loss is substantially reduced in pushed waves that arise due to cooperative growth. In such expansions, the low-density tip of the front grows much more slowly and is often reseeded from the genetically diverse population core. Additionally, in both pulled and pushed expansions, we observe a few instances of abrupt changes in allele fractions due to rare fluctuations of the expansion front and show how to distinguish such rapid genetic drift from selective sweeps.

Sign in / Sign up

Export Citation Format

Share Document