Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM  in the Anterior Cingulate Cortex

Science ◽  
2010 ◽  
Vol 330 (6009) ◽  
pp. 1400-1404 ◽  
Author(s):  
X.-Y. Li ◽  
H.-G. Ko ◽  
T. Chen ◽  
G. Descalzi ◽  
K. Koga ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pain Hypersensitivity

scholarly journals A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

Bioengineered ◽  
2022 ◽  
Vol 13 (2) ◽  
pp. 2058-2075
Author(s):  
Yu Zhang ◽  
Shiwei Jiang ◽  
Fei Liao ◽  
Zhifeng Huang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Nerve Injury ◽  
Cingulate Cortex ◽  
Transcriptomic Analysis ◽  
Anterior Cingulate

Author response: Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: Disassembling the percept of pain

Neurology ◽  
2020 ◽  
Vol 94 (16) ◽  
pp. 721-722
Author(s):  
Daniel Ciampi de Andrade ◽  
Ricardo Galhardoni ◽  
Valquíria Aparecida da Silva ◽  
Luís García-Larrea ◽  
Camila Dale ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Author Response ◽  
Central Neuropathic Pain

Expression of muscarinic M1 and M2 receptors in the anterior cingulate cortex associated with neuropathic pain

2010 ◽  
Vol 14 (9) ◽  
pp. 901-910 ◽  
Author(s):  
J. Manuel Ortega-Legaspi ◽  
Martha León-Olea ◽  
Patricia de Gortari ◽  
María Isabel Amaya ◽  
Ulises Coffeen ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain

Synapse ◽  
2014 ◽  
Vol 68 (6) ◽  
pp. 235-247 ◽  
Author(s):  
Akira Yamashita ◽  
Asami Hamada ◽  
Yuki Suhara ◽  
Rui Kawabe ◽  
Makoto Yanase ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sleep Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion

2021 ◽  
Vol 17 ◽  
pp. 174480692110619
Author(s):  
Xiao Zhang ◽  
Peng Liu ◽  
Xiaolan He ◽  
Zhenhua Jiang ◽  
Qun Wang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Patch Clamp ◽  
Anterior Cingulate Cortex ◽  
Mechanical Allodynia ◽  
Pain Perception ◽  
Cingulate Cortex ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Fos Expression ◽  
Aversive Behavior

Background While the PKCγ neurons in spinal dorsal horn play an indispensable part in neuropathic allodynia, the exact effect of PKCγ neurons of brain regions in neuropathic pain remains elusive. Mounting research studies have depicted that the anterior cingulate cortex (ACC) is closely linked with pain perception and behavior, the present study was designed to investigate the contribution of PKCγ neurons in ACC to neuropathic allodynia and pain-related emotion in newly developed Prkcg-P2A-Tdtomato mice. Methods The c-fos expression in response to innocuous stimulation was used to monitor the activity of PKCγ in CCI (chronic constriction injury of the sciatic nerve) induced neuropathic pain condition. Activating or silencing ACC PKCγ neurons by chemogenetics was applied to observe the changes of pain behavior. The excitability of ACC PKCγ neurons in normal and CCI mice was compared by patch-clamp whole-cell recordings. Results The PKCγ-Tdtomato neurons were mainly distributed in layer III-Vof ACC. The Tdtomato was mainly expressed in ACC pyramidal neurons demonstrated by intracellular staining. The c-fos expression in ACC PKCγ neurons in response to innocuous stimulation was obviously elevated in CCI mice. The patch clamp recordings showed that ACC PKCγ-Tdtomato neurons were largely activated in CCI mice. Chemogenetic activation of ACC PKCγ neurons in Prkcg-icre mice induced mechanical allodynia and pain-related aversive behavior, conversely, silencing them in CCI condition significantly reversed the mechanical allodynia and pain-related place aversive behavior. Conclusion We conclude that the PKCγ neurons in ACC are closely linked with neuropathic allodynia and pain-related emotional behaviors.

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