Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

Science ◽  
2007 ◽  
Vol 317 (5839) ◽  
pp. 807-810 ◽  
Author(s):  
A. S. Brack ◽  
M. J. Conboy ◽  
S. Roy ◽  
M. Lee ◽  
C. J. Kuo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Muscle Stem Cell ◽  
Stem Cell Fate

Analysis of Muscle Stem Cell Fate Through Modulation of AMPK Activity

2018 ◽  
pp. 539-549
Author(s):  
Marine Theret ◽  
Linda Gsaier ◽  
Sabrina Ben Larbi ◽  
Michèle Weiss-Gayet ◽  
Rémi Mounier
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Muscle Stem Cell ◽  
Stem Cell Fate ◽  
Ampk Activity

Targeting Wnt Signaling through Small molecules in Governing Stem Cell Fate and Diseases

2019 ◽  
Vol 19 (3) ◽  
pp. 233-246 ◽  
Author(s):  
Antara Banerjee ◽  
Ganesan Jothimani ◽  
Suhanya Veronica Prasad ◽  
Francesco Marotta ◽  
Surajit Pathak
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Wnt Signaling ◽  
Small Molecules ◽  
Signaling Pathway ◽  
Cell Fate ◽  
Wnt Pathway ◽  
Molecular Mechanisms ◽  
Wnt Signaling Pathway ◽  
Stem Cell Fate

Background:The conserved Wnt/β-catenin signaling pathway is responsible for multiple functions including regulation of stem cell pluripotency, cell migration, self-renewability and cell fate determination. This signaling pathway is of utmost importance, owing to its ability to fuel tissue repair and regeneration of stem cell activity in diverse organs. The human adult stem cells including hematopoietic cells, intestinal cells, mammary and mesenchymal cells rely on the manifold effects of Wnt pathway. The consequences of any dysfunction or manipulation in the Wnt genes or Wnt pathway components result in specific developmental defects and may even lead to cancer, as it is often implicated in stem cell control. It is absolutely essential to possess a comprehensive understanding of the inhibition and/ or stimulation of the Wnt signaling pathway which in turn is implicated in determining the fate of the stem cells.Results:In recent years, there has been considerable interest in the studies associated with the implementation of small molecule compounds in key areas of stem cell biology including regeneration differentiation, proliferation. In support of this statement, small molecules have unfolded as imperative tools to selectively activate and inhibit specific developmental signaling pathways involving the less complex mechanism of action. These compounds have been reported to modulate the core molecular mechanisms by which the stem cells regenerate and differentiate.Conclusion:This review aims to provide an overview of the prevalent trends in the small molecules based regulation of stem cell fate via targeting the Wnt signaling pathway.

Wnt Signaling and the Control of Human Stem Cell Fate

2013 ◽  
Vol 10 (2) ◽  
pp. 207-229 ◽  
Author(s):  
J. K. Van Camp ◽  
S. Beckers ◽  
D. Zegers ◽  
W. Van Hul
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Human Stem Cell ◽  
Stem Cell Fate

scholarly journals An evolutionary conserved role of Wnt signaling in stem cell fate decision

2006 ◽  
Vol 289 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Regina Teo ◽  
Frank Möhrlen ◽  
Günter Plickert ◽  
Werner A. Müller ◽  
Uri Frank
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Decision ◽  
Stem Cell Fate ◽  
Fate Decision
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