Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Science ◽  
2007 ◽  
Vol 315 (5809) ◽  
pp. 187.2-187 ◽  
Author(s):  
Christian Dina ◽  
David Meyre ◽  
Chantal Samson ◽  
Jean Tichet ◽  
Michel Marre ◽  
...  
Keyword(s):  
General Population ◽  
Genetic Variant ◽  
Population Studies ◽  
Case Control ◽  
Recessive Model ◽  
Gene Variant ◽  
General Population Studies ◽  
Common Genetic Variant ◽  
Family Based

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

scholarly journals Association Study of Genetic Variants inCDKN2A/CDKN2BGenes/Loci with Late-Onset Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Andrea Tedde ◽  
Irene Piaceri ◽  
Silvia Bagnoli ◽  
Ersilia Lucenteforte ◽  
Uwe Ueberham ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Variants ◽  
Genetic Variant ◽  
Case Control Study ◽  
Late Onset ◽  
Common Genetic Variant ◽  
Genome Wide ◽  
Control Study

Alzheimer's disease (AD) is the most common form of dementia clinically characterized by progressive impairment of memory and other cognitive functions. Many genetic researches in AD identified one common genetic variant (ε4) in Apolipoprotein E (APOE) gene as a risk factor for the disease. Two independent genome-wide studies demonstrated a new locus on chromosome 9p21.3 implicated in Late-Onset Alzheimer's Disease (LOAD) susceptibility in Caucasians. In the present study, we investigated the role of three SNP's in theCDKN2Agene (rs15515, rs3731246, and rs3731211) and one in theCDKN2Bgene (rs598664) located in 9p21.3 using an association case-control study carried out in a group of Caucasian subjects including 238 LOAD cases and 250 controls. The role ofCDKN2AandCDKN2Bgenetic variants in AD is not confirmed in our LOAD patients, and further studies are needed to elucidate the role of these genes in the susceptibility of AD.

Sexual assault history and social support: Six general population studies

2002 ◽  
Vol 15 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Jacqueline M. Golding ◽  
Sharon C. Wilsnack ◽  
M. Lynne Cooper
Keyword(s):  
Social Support ◽  
Sexual Assault ◽  
General Population ◽  
Population Studies ◽  
General Population Studies

Short-term effects of particulate matters on pulse pressure in two general population studies

2015 ◽  
Vol 33 (6) ◽  
pp. 1144-1152 ◽  
Author(s):  
Dai-Hua Tsai ◽  
Idris Guessous ◽  
Michael Riediker ◽  
Fred Paccaud ◽  
Jean-Michel Gaspoz ◽  
...  
Keyword(s):  
General Population ◽  
Pulse Pressure ◽  
Population Studies ◽  
Particulate Matters ◽  
General Population Studies ◽  
Short Term ◽  
Short Term Effects

scholarly journals The Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice

2020 ◽  
Author(s):  
M. L. Bezemer ◽  
E. M. A. Blijd-Hoogewys ◽  
M. Meek-Heekelaar
Keyword(s):  
Clinical Practice ◽  
General Population ◽  
Predictive Value ◽  
Population Studies ◽  
Clinical Population ◽  
Patient Records ◽  
General Population Studies ◽  
Predictive Values ◽  
Better Than ◽  
Autism Assessment

Abstract Questionnaires are widely used in autism assessment. However, their psychometric properties are generally not evaluated in clinical practice, and the comparability and applicability of such research is limited because questionnaires are often not simultaneously evaluated. This certainly pertains to predictive values which are highly population and setting specific. This study evaluated the power of AQ and SRS-A in predicting an ASD diagnosis within the same clinical population. The patient records of 92 adults, referred for autism assessment, were analyzed. The AQ proved somewhat better than the SRS-A at discriminating and predicting autism. The predictive values of both questionnaires were lower than reported in general population studies. Psychometric results in core publications appear less representative for clinical practice.

Let it be sexual: how health care transmission of AIDS in Africa was ignored

2003 ◽  
Vol 14 (3) ◽  
pp. 148-161 ◽  
Author(s):  
David Gisselquist ◽  
John J Potterat ◽  
Stuart Brody ◽  
Francois Vachon
Keyword(s):  
Health Care ◽  
General Population ◽  
Population Studies ◽  
Risk Measures ◽  
Sexual Transmission ◽  
Hiv Infections ◽  
Heterosexual Transmission ◽  
Evidence Based ◽  
General Population Studies ◽  
Direction Of Causation

The consensus among influential AIDS experts that heterosexual transmission accounts for 90% of HIV infections in African adults emerged no later than 1988. We examine evidence available through 1988, including risk measures associating HIV with sexual behaviour, health care, and socioeconomic variables, HIV in children, and risks for HIV in prostitutes and STD patients. Evidence permits the interpretation that health care exposures caused more HIV than sexual transmission. In general population studies, crude risk measures associate more than half of HIV infections in adults with health care exposures. Early studies did not resolve questions about direction of causation (between injections and HIV) and confound (between injections and STD). Preconceptions about African sexuality and a desire to maintain public trust in health care may have encouraged discounting of evidence. We urge renewed, evidence-based, investigations into the proportion of African HIV from non-sexual exposures.

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