Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

Science ◽  
2006 ◽  
Vol 311 (5762) ◽  
pp. 864-868 ◽  
Author(s):  
O. Berton
Keyword(s):  
Essential Role ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Mesolimbic Dopamine ◽  
Mesolimbic Dopamine Pathway

scholarly journals Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area

2014 ◽  
Vol 232 (9) ◽  
pp. 1555-1569 ◽  
Author(s):  
Jasmine J. Yap ◽  
Elena H. Chartoff ◽  
Elizabeth N. Holly ◽  
David N. Potter ◽  
William A. Carlezon ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Social Defeat ◽  
Erk Signaling ◽  
Social Defeat Stress ◽  
Self Administration ◽  
Ventral Tegmental

scholarly journals Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine

2019 ◽  
Author(s):  
Kai Zhang ◽  
Akemi Sakamoto ◽  
Lijia Chang ◽  
Youge Qu ◽  
Siming Wang ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Molecular Mechanisms ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Beneficial Effects ◽  
Nkg2d Expression ◽  
Chronic Social Defeat Stress ◽  
Group 2 ◽  
Stress Susceptibility

AbstractThe spleen is a large immune organ that plays a key role in the immune system. The precise molecular mechanisms underlying the relationship between the spleen and stress-related psychiatric disorders are unknown. Here we investigated the role of spleen in stress-related psychiatric disorders. FACS analysis was applied to determine the contribution of the spleen to susceptibility and resilience in mice that were subjected to chronic social defeat stress (CSDS). We found a notable increase in splenic volume and weight in CSDS-susceptible mice compared to control (no CSDS) mice and CSDS-resilient mice. The number of granulocytes, but not of T cells and B cells, in the spleen of susceptible mice was higher than in the spleen of both control and resilient mice. Interestingly, NKG2D (natural killer group 2, member D) expression in the spleen of CSDS-susceptible mice was higher than that in control mice and CSDS-resilient mice. In addition, NKG2D expression in the spleen of patients with depression was higher than that in controls. Both increased splenic weight and increased splenic NKG2D expression in CSDS-susceptible mice were ameliorated after a subsequent administration of (R)-ketamine. The present findings indicate a novel role of splenic NKG2D in stress susceptibility versus resilience in mice subjected to CSDS. Furthermore, abnormalities in splenic functions in CSDS-susceptible mice were ameliorated after subsequent injection of (R)-ketamine. Thus, the brain–spleen axis might, at least in part, contribute to the pathogenesis of stress-related psychiatric disorders such as depression.

scholarly journals The protective role of Neuregulin1-ErbB4 signaling in a chronic social defeat stress model

Neuroreport ◽  
2020 ◽  
Vol 31 (9) ◽  
pp. 678-685
Author(s):  
Wenjuan Wang ◽  
Yong Qiao ◽  
Huiying Qu ◽  
Lin Zhu ◽  
Linlin Mu ◽  
...  
Keyword(s):  
Social Defeat ◽  
Protective Role ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress

scholarly journals Essential Role of Ovarian Hormones in Susceptibility to the Consequences of Witnessing Social Defeat in Female Rats

2018 ◽  
Vol 84 (5) ◽  
pp. 372-382 ◽  
Author(s):  
Julie E. Finnell ◽  
Brandon L. Muniz ◽  
Akhila R. Padi ◽  
Calliandra M. Lombard ◽  
Casey M. Moffitt ◽  
...  
Keyword(s):  
Essential Role ◽  
Social Defeat ◽  
Ovarian Hormones ◽  
Female Rats
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